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BioChiral is founded in 2014 as Contract Research Organization (CRO), Custom Research & Manufacturing Services (CRAMS), API intermediates and impurities to wide range of customers from Usa, Canada, European and Asian countries. BioChiral is located in Hyderabad (Pharma hub of India), in the close vicinity of internationally reputed Indian Institute of Chemical Technology (IICT), Center for Cellular and Molecular Biology (CCMB), Osmania University and National Institute for Pharmaceutical Educational and Research (NIPER), etc.Our Management team is consisting of professionals with Ph.Ds and Master in organic Chemistry, which is capable of providing a wide variety of outsourcing services and can supply a broad range of synthetic compounds in gram to kilogram scale. BioChiral is highly motivated and feels responsible for product quality, customer satisfaction, cost effectiveness and environment protection.+ Read More

Nature of Business

Manufacturer

Total Number of Employees

11 to 25 People

Year of Establishment

2014

Legal Status of Firm

Individual - Proprietor

BioChiral Project Management
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Request for Proposal (RFP) Evaluation

BioChiral quotes best cost effective pricing model that includes "Synthesis of Target Compound, Purification and Analysis, Literature Support, Chemical sourcing and shipping and Project management tools between BioChiral and the client" or between BioChiral and the client's CRO. BioChiral CRO scientific team is capable of provides a best Route of Synthesis (ROS) and alternative of ROS for target compounds based on literature.

Execution of Project

BioChiral CRO scientific team consists of experienced Ph.D and Master Students, who have ability to synthesis the target molecule in stipulated timelines. BioChiral always keeps 20% buffer back up team for project. Our pioneer Group leader will prepare weekly reports and arranges a tele-Conference with Client on weekly basis. All the intermediates and final Compounds are analyzed characterized by NMR and LCMS purity. After completion of Project, BioChiral project Management team will provides Final reports in Word format (Doc & Docx) and Structural data format (SDF & Excel) documentation in Client defined format.

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API Intermediates and Impurities ( Non-GMP)
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BioChiral process development chemists are specializing in the design and optimization of synthetic routes for gram to multi-kilo quantities of compounds suitable for the transfer of laboratory procedures into the pilot plant. We aim to develop scalable, safe and economical solutions.

  • Route of synthesis- optimization and validation
  • Custom research and manufacturing process
  • Scale-up & optimization intermediates and related chemicals
  • Scale up from lab to pilot and pilot to commercialization (mg level to 1000kg level)
  • Impurity profiling.
  • Our customers appreciate the contribution we make to solve their chemical synthesis challenges.

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Custom Research  Services (CRAMS)
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At BioChiral ' facilities, highly skilled chemists routinely carry out syntheses of complex intermediates and final products With/without technology transfer; starts with process development/optimization and approval of lab sample, followed by commercial validation campaign, regulatory filing and approval and then the long-term commercial supply.

  • Route of Synthesis (ROS)/Process Development.
  • Route/ Process Optimization.
  • Scale-up of established processes
  • Identification of alternate viable synthetic methods.
  • Scale up synthesis of gram/ kilogram quantities of intermediates, building blocks and Scaffolds.
  • Impurities – identification, characterization and synthesis.

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Medicinal Chemistry /
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Medicinal Chemistry /

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BioChiral have extensive experience in synthesizing compounds designed by medicinal chemists at our clients' site. Our major focus is given on productivity (milligram to kilogram scale) and cycle time management in these efforts with real time problem solving in synthesis.

  • Medicinal Important compound.
  • Biologically active Compounds.
  • Metabolites,  and Macrolides.
  • Steroids and Prostaglandins.
  • API reference standards and Impurity standards.
After completion of the project all the experimental reports would captured into word format (doc or docx) or Structural Database (SD) according Client defined format

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Library Synthesis / Parallel Synthetic Chemistry
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BioChiral have extensive experience in synthesis of a variety of libraries ranging between focused libraries 10-30 members to large 2000 member libraries, scaffolds/building blocks including complex structure involving multi-step synthesis in milligram to kilogram scale with complete characterization, lead generation, lead optimization and SAR libraries generated in 5-50 mg scale with >90% purity of LCMS.

After synthesis of the library compounds, BioChiral would capture all the synthetic procedure into SAR tables and Structural Database (SD) format in Client defined format.

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Nucleoside / Sugar Chemistry
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BioChiral Scientific team have experienced in Modification of Nucleoside bases, Metal Mediating Reactions on Nucleosides (Suzuki, Sonogashira, Heck, Kumada, Stille, Carbonylation and Buchwald couplings) Modification of Sugar Moieties, Alkylation, Fluorination Reaction at Nucleosides Based and Sugar Moieties.

  • Development of novel methodologies for the synthesis of modified nucleobases and nucleosides.
  • Medicinal chemistry of analogues of nucleobases and nucleosides.
  • Design and synthesis of novel C-nucleosides for chemical biology.
  • Synthesis of modified nucleoside triphosphates.
  • Novel fluorescent DNA labeling for bioanalytical applications.
  • Chemical biology of base-modified nucleic acids.
  • Click Reaction Applications in Nucelobases.

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Amino Acid / Peptide Chemistry
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BioChiral pioneer Scientific team have experienced in Synthesis of Protected N-Terminal & C- Terminal Amino Acids Scaffolds & Di-peptides, Cyclic Peptides.

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Material Chemistry / Polymer Chemistry
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BioChiral Scientific team have experienced in synthesis of Photoactive conducting polymers, charge transporting polymers, external stimulii small molecules.

Organic Light-Emitting Diode (OLED) Materials

Solar Cells: Dye-Sensitized Solar cells and Organic photovoltaic, cells, Conductind Polymers, Organic Dyes.

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