Bupivacaine is a long acting local anaesthetic agent that belongs to amide group & injection is sterile, non-pyrogenic, isotonic, single dose container. It contains an amide linkage between the aromatic nucleus and the amino or piperidine group.

it blocks the generation and the conduction of nerve impulses, by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential.

bupivacaine can have both stimulating and depressing effects on cns & can fluctuate cardiac conduction.

Ciprox, is a 2nd generation, broad spectrum quinolone. It is a potent aerobicidal drug acting on the aerobic bacterial infections.

• Gastrointestinal infections
• Intra abdominal infections
• ENT infections
• Respiratory tract infections
• Urinary tract infections
• Bone & joint infections
• Gynecological infections

Neudoc is docetaxel injection concentrate available along with its respective solvent. Docetaxel is an anti-metabolite agent known as a taxane. Taxanes are cytotoxic agents that work on a molecule called tubulin.

Lipeg (Doxorubicin HCL liposome injection) is doxorubicin hydrochloride (HCL) encapsulated with surface bound methoxypolyethyleneglycol Liposome’s for intravenous administration

• Lipeg is a cytotoxic anthracycline antibiotic
• Uses novel, targeted delivery system to help, evade recognition and Uptake by the immune system.
• Longer circulation increases the efficacy of the drug to the tumor site

Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as a sterile solution for intravenous use. It is available as 200mg/100ml infusion.

• vaginal candidiasis
• mucosal candidiasis
• systemic candiasis
• cryptocococosis
• prevention of fungal infection in patients with malignancy, aids, in intensive care units and patients on immunosuppressive drugs.

Fegrast is human granulocyte colony-stimulating factor (G-CSF), produced by recombinant DNA technology. Filgrastim is available in prefilled syringe. Filgrastim is in a class of medications called colony-stimulating factors. It works by helping the body make more neutrophils
Filgrastim is used to decrease the chance of infection in people who have certain types of cancer and are receiving chemotherapy medications that may decrease the number of neutrophils
(a type of blood cell needed to fight infection), in people who are undergoing bone marrow transplants, and in people who have severe chronic neutropenia (condition in which there are a low number of neutrophils in the blood).

jemcita is gemcitabine injection . gemcitabine is a nucleoside analog used as chemotherapy in many cancer. Gemcitabine targets and kills cancer cells. It does this by damaging the dna within the cell rendering it incapable of dividing.

exhibits cell phase specificity, primarily killing cells undergoing dna synthesis in the s-phase. It also blocks the progression of cells through the g1/s-phase boundary.

Element is a clear, colorless injection of L-Alanah L-Glutamate.

Glutamate peptides refer to certain peptides used in total parenteral nutrition (TPN) as delivery forms of L-glutamate. The term also refers to peptides containing L-glutamate, which are found in some nutritional supplements, particularly those marketed as sports and fitness products.

L-glutamate depletion is a typical feature of such metabolic stress conditions as trauma (including surgical trauma), infection, sepsis, cancer and severe burns. The metabolic response to these conditions is characterized by metabolism and negative nitrogen balance. Under these conditions, L-glutamate, which is normally manufactured by the body (mainly in skeletal muscles) in sufficient quantities to satisfy physiological demands, is required exogenously.

Under these conditions, L-glutamate becomes an essential amino acid and must be supplied to the body in order to prevent breakdown of muscle tissue, immune dysfunction and compromise of the gut mucosa barrier function with consequent bacterial trans location into the body.

Hestar-200 & hestar-450 are clear, colourless hydroxyethyl starch solutions used as plasma volume expander / blood substitute in shock, hypovolemia, acute blood loss, hypotension, etc. , to maintain normal blood pressure and volume. They improve oxygen transport to all vital organs of the body.

hestar-200 : pentastarch [hydroxyethyl starch (200/0. 5)] solution isotonic with 0. 9% sodium chloride for intravenous infusion.

hestar-450 : hetastarch [hydroxyethyl starch (450/0. 7)] solution isotonic with 0. 9% sodium chloride for intravenous infusion.

Iron sucrose Injectable is a sterile aqueous complex, non-phylogenic aqueous complex containing 20 mg/mL of Iron suitable for intravenous administration.

Iron sucrose is dissociated into iron and sucrose by the reticuloendothelial system and iron is transferred form the blood to a bone marrow. The Ferritin the iron storage protein binds and sequesters iron into a nontoxic iron that is easily available. The iron binds to plasma transferring that is carries iron to extracellular fluid to supply to tissues. The transferring receptors presented in membrane binds transferrin iron complex which is then internalized in vesicles iron is released within the cell and transferrin-receptor complex is return to the cell membrane transferrin without iron is then releases to the plasma. The intracellular iron becomes hemoglobin on circulating red blood cells. Transferrin synthesis increased Ferritin production reduced in iron deficiency.

Engenase is L-asparaginase inj. While observing the qualitative difference between normal cells and those from childhood lymphoblastic leukemia, the leukemia cells are deficient in L-asparagine synthetase and depend on the supply of L-asparagine from the medium (Blood). The enzyme L-asparaginase (from E. coil) degrades L-asparagine to L-aspartic acid, depriving leukemic cells of an essential metabolite and ultimately may lead to cell death."

Levox IV is a 3rd generation, synthetic broad-spectrum quinolone. It is used inall severe bacterial infections.

• Acute maxillary sinusitis
• Acute bacterial exacerbation of chronic bronchitis
• Community-acquired pneumonia
• Uncomplicated skin and skin structure infections
• Complicated urinary tract infections
  • Acute pyelonephritis
• Uncomplicated urinary tract infections

Lidocaine (lignocaine) is the most important amide local anesthetic. Like other local anesthetics, it slows down the depolarization of the nerve cell membrane. This effect is based on the interaction with a specific receptor site in the sodium channel. Lidocaine reduces the automaticity in the conductive system of the heart by slowing down the diastolic depolarization.

lidocaine can have a stimulating or a sedative effect on the central nervous system.

Linezox, is a synthetic novel antibacterial agent in the new class of antibiotics called oxazolidinones. This new class has a unique chemical structure and a novel mechanism of action. Therefore, cross-resistance between anzolid and other classes of antibiotics is unlikely.

clinical and microbiological findings demonstrate that anzolid has clinical utility and is effective and safe for the treatment of certain infections caused by indicated aerobic gram +ve bacteria.

Claris Introduces Smooth Painless Intravenous Anesthesia with SPIVA, the IV anesthetic agent of choice with the benefits of MCT LCT propofol.

SPIVA ensures faster metabolism of lipid and thus offers
• Less pain on site of injection
• Less Lipid Load

Thus best suitable IV anesthetic agent for Pediatric patients and Obese/Hyperlipidemic patients undergoing cardiac surgeries/ICU Sedation/MAC Sedation.

MERIVA (Meropenem Sodium Inj.) is an ultra broad-spectrum antibiotic, which is generally used as a last resort of antibiotic to treat severe ICU infections. Considering the fact ICU’s are the most vulnerable place for the nosocomial infections and the increase in incidence of resistance to Cephlosporin antibiotics, MERIVA (Meropenem) is an effective alternative to bring respite to both the intensives and the patient fighting against the critical illnesses in ICUs.

Dextrose is the combination of dextrose and metronidazole available for intravenous administration.

dextroplus contain dextrose which provides energy whereas metronidazole fights against anaerobic infection.

• surgical prophylaxis
• gynecological infection
• intra-abdominal infections

Metris is a potent anerobicidal.

In mixed infections, when aerobic & anaerobic bacteria coexist, Metronidazole is used along with conventional antibiotics.

• Gastrointestinal infections
• Intra abdominal infections
• ENT infections
• Respiratory tract infections
• Urinary tract infections
• Skin & soft tissue infections
• Bone & joint infections
• Gynecological infections

sedoz (midazolam) is a short acting benzodiazepine with sedative-general anaesthetic properties. It can be used to produce sleepiness or drowsiness and to relieve anxiety before surgery or certain procedures. It can also be used to produce loss of consciousness before / during surgery, or in the intensive care unit (ICU).

clinically well accepted, midazolam (sedoz) and propofol (profol), have a synergistic effect. Midazolam (sedoz) works as a good premedication as well as a partner in total intravenous anesthesia, with profol (propofol).

Electrolyte E is extracellular replacement solution and has same composition as plasma. It provides physiological concentration of sodium and chloride and also potassium, calcium, magnesium and bicarbonate precursors.

Thus, it can replace the losses of intravascular and interstitial fluid.

Electrolyte m is an adult's daily maintenance solution. It provides daily needs of water and electrolytes to the body without exceeding body's tolerance for them.

• in maintenance therapy for providing daily electrolyte and energy to the patient
• in the treatment of mild acidosis
• water depletion due to reduction in water intake
• in condition like burns, vomiting diarrhoea etc. , where there is potassium deficit

Norglobin ivig is an aqueous sterile solution of immunoglobulin for intravenous infusion, containing 5% human protein. Ivig is prepared from human plasma by cold alcohol fractionation according to the kistler & nitschmann process. The immune globulin is purified by chromatography and ultrafiltration without any enzymatic treatment or chemical modifications to the igg molecule. The final product contains 10% maltose and its ph is adjusted to 4. 0

it is strictly screened against viruses like hiv-1, hiv-2, hcv, hbc, lues, alt etc.

Parenteral amino acids solutions supplementation forms an integral part of total parenteral nutrition (tpn) therapy. The celemin range of products is specially designed to meet the varied protein requirements of critically ill patients. The range varies from the simplest formulation like celemin 10 plus (which provides all essential & non-essential amino acids along with electrolytes) to complex formulations like celemin hepa (specially designed for patients with hepatic insufficiency) and celemin nephro specially designed for patients with renal insufficiency.

Celepid - the parenteral fat emulsion - is a milky-white emulsion of soybean oil-in-water, and is used as a source of concentrated energy as well as to counter essential fatty acid deficiencies in critically ill patients. World-class quality of raw material, emulsion manufacturing technology, and above all our commitment to nutrition makes celepid one of the safest lipid emulsion products in the world.

Multiple parenteral trace elements are small volume injections, launched for the first time in India. They provide all the micronutrients (trace elements) to the patient who is on Total Parenteral Nutrition therapy or has developed or is at risk of developing trace element deficiencies. Depending on the deficiency and need, one can choose the volume and type of injection.

Provive / profol is a white, oil in water, isotonic emulsion for intravenous injection containing 10 mg propofol in each ml along with excipients soybean oil, glycerol, egg lecithin and sodium hydroxide to adjust ph. Our state-of-the-art manufacturing technology and, above all, our commitment to critical care, makes provive / profol a market leader in the intravenous anesthesia segment.

Thiopentone sodium is an ultra short-acting barbiturate derivative, which induces hypnosis and anesthesia, but not analgesia. It produces hypnosis within 30 to 40 seconds of intravenous injection.

thiopentone sodium is a thiobarbiturate, the sulfur analogue of sodium pentobarbital.

the drug is a yellowish, hygroscopic powder, stabilized with anhydrous sodium carbonate as a buffer (60 mg/g of thiopentone sodium). The drug is prepared as a sterile lyophilized powder and after reconstitution with appropriate diluents, administered by the intravenous route.

commonly used diluents for reconstitution are:
• 5% dextrose solution
• sterile water for injection
• 0. 9% sodium chloride injection

Daily human nutritional requirement comprises mainly of proteins, carbohydrates, fats, and other nutrients. One big success achieved is the simultaneous administration of these nutrients using CELEMIX. It represents convenience through ease of use. Celemix is ideally suited for short-term parenteral nutrition with an advantage of administration through peripheral vein.

Cyrin is as an immunosuppresant, required to prevent the rejection of graft (organ) after transplantation. Cyrin is used to prevent the rejection of kidney, skin, heart, pancreas, bone marrow, small intestine and lungs post transplantation.

Glutammune is pure l-glutamine in granule form, which can be taken orally as well as through tube feeding.

since glutamine improves gut function, and is a very good fuel for intestinal cells, it is used in all types of gi disorders / diseases. Glutamine increases immunity therefore it is used in all icu patients. In cancer patients, glutamine is used for its properties of reducing the size of tumors.

glutammune can be given orally or with enteral nutrition. It can be mixed with water, any favorite drink/juice or added to food.

glutammune is available in 15 g sachet, in each 15 g of sachets contains 10 g of glutamine.

Renograf is a euro collins solution, used for hypothermic flushing and storage of organs including kidneys, liver and pancreas for transportation and preservation prior to transplantation. This solution is used for live and cadaveric transplantation. It can preserve the kidney upto 48 hours.

Microspan- 40 is a clear, colourless, 10% w/v solution of low molecular weight dextran 40 (40,000 da) isotonic in 5% dextrose or 0. 9% sodium chloride solution.

microspan- 70 is a clear, colourless, 6% w/v solution of low molecular weight dextran 70 (70,000 da) isotonic in 5% dextrose or 0. 9% sodium chloride solution.

microspan is known to improve micro circulation, exhibit thromboprophylactic activity and prevent hypovolaemia.

Curadex is a 2nd generation synthetic, broad spectrum quinolone.

curadex has in-vitro activity against a broad spectrum of gram +ve and gram –ve aerobic and anaerobic bacteria.

• gastro intestinal infection
  • typhoid
  • pancreatitis
• multi drug resistant tb
• sexually transmitted diseases
  • pelvic inflammatory disease
  • acute uncomplicated urethral and cervical gonorrhoea
  • nongonococcal urethritis and cervicitis
• uncomplicated cystitis
• mixed infections of the urethra and cervix
• urinary tract infections

Satisfactory delivery systems are the essence of Total Parenteral Nutrition. Since current formulations do not provide adequate nutritional support for hypercatabolic stressed patients, need for continuous development of prepackaged delivery system was always felt. Thus evolved the concept of PNA (Parenteral Nutrient Admixture). PNA enables the administration of all the essential nutrients required for 24 hrs., with the flexibility of customizing the solution by further nutrient supplementation.

PNA is available in double chambered EnerG bag with the provision to add extra nutrition like, glucose, amino acid, lipid, vitamins, trace elements, and minerals. PNA is convenient to administer and monitor and require less nursing time. PNA is Parenteral Nutrition. . . . customized to your needs.

Tetrahes is our brand for tetrastarch, a variant of hydroxyethyl starch. It falls under the category of colloidal plasma volume expanders. It is a modified natural polymer of amylopectin with volume expansion properties with the average molecular weight of 1,30,000 dalton and degree of substitution 0. 4. Tetrahes is a clear colorless to pale yellow solution filled in a 500 ml non-pvc bag. It is used as plasma volume expander/ blood substitute to maintain normal blood pressure and volume in shock, hypovolemia, acute blood loss, hypotension, etc. It improves oxygen transport to all vital organs of the body.

The concept of Total Nutrient Admixture is to provide all macro nutrients including amino acids, lipids and carbohydrates in a single delivery system. The objective is to provide the patient optimum resources for better outcome.

Triple Chamber Bag systems offer flexibility and convenience over conventional glass bottle systems. One of the Prime features of TNA is the advanced delivery system in the form of triple chamber bag, where in all three macro nutrients are filled into three different chambers. Together yet separate till they have to be infused to the patient.

Mygraft is mycophenolate mofetil is a synthetic analogue of mycophenolic acid that is produced by several penicillium species. It is an antiproliferative immunosuppresant, used in combination with cyclosporine and other corticosteroids for the prophylaxis of acute rejection in renal, hepatic or cardiac transplant. Mycophenolate mofetil is proved as safer and efficious immunosuppresant to prevent graft rejections, thus improve overall patient survival.

Calbin is a phosphate binder tablet. It contains calcium acetate as phosphate binder. It is used in hyperphosphatemia in kidney failure patients, i. E. , it controls increased phosphate level. It delays progression of crf, if given at an early stage with 25% residual renal function. It prevents renal osteodystrophy and secondary calcification of soft tissue.

Ketolog is ketoanalogue of essential amino acid tablet. Ketolog contains all amino acids essential for uremic patients, five out of them are keto or hydroxyanalogues in the form of calcium salts. Therefore it allows reduction in the nitrogen supply and provides calcium. It is a medication for the treatment of chronic kidney disease patients on conservative management therapy (ckd stage i, ii, iii). In combination with very low protein diet / low protein diet, it helps in delaying the progression of kidney disease in the predialysis period.

Limus contains sirolimus an immunosuppresant. Sirolimus is a carbocyclic lactone-lactam macrolide antibiotic prepared through natural fermentation from the soil actinomycete streptomyces hygroscopicus. It was discovered about 25 years ago in easter island.

OSTRIOL is a soft gelatin capsule containing 0.25 mcg Calcitriol BP which is the most active and natural form of Vit. D3 and, OSTRIOL.

• Increases intestinal reabsorption of calcium.
• Increases reabsorption and mineralisation in bone.
• Shuts off parathyroid hormone production.
• Regulates calcium and phosphorus metabolism.

ESSAMIN is an essential amino acid tablet. It contains eight essential amino acids along with two non essential amino acids, Histidine and Tyrosine, whose rate of synthesis is reduced in patients with Chronic Renal Failure (CRF).

Due to protein restrictions there may be chances of deficiency of amino acids in kidney failure patients. ESSAMIN normalizes plasma amino acid concentration, increases protein synthesis in body, and reduces the progression of CRF.

Nindividuals & patients who are not able to take, digest or absorb normal food or who have special nutritional requirements as a results of metabolic disorders. Nourish contains specific nutrients, shown to be of benefit for the nutritional management of disease conditions. The contents of carbohydrates, proteins, fats, vitamins, minerals and trace elements are adjusted according to the special needs of patients.

Sucron ( Iron Sucrose Injection ) is a brown, sterile, aqueous complex of polynuclear iron (iii) – hydroxide in sucrose containing 20 mg elemental iron per ml.

After administration Iron Sucrose dissociates into Iron and Sucrose. The iron component is transferred to the liver, in the liver iron is sequestered by protein thus forming Ferritin. Iron is stored in the body in the form of Ferritin which is non toxic unlike free iron.

When iron is required for RBC formation or in other important pathways in the body, iron from ferritin is released and combines with apotransferrin , a protein present in blood. On combining with apotransferrin(present in plasma) it forms Transferrin, iron is transported through blood in form of Transferrin. Transferrin receptors, located in the cell membrane of bone marrow, bind the transferrin iron complex, which is then internalized in vesicles.Iron is released within the cell, and the transferrin-receptor complex is returned to the cell membrane. Transferrin without iron (apotransferrin) is then released to the plasma.The intracellular iron becomes (mostly) hemoglobin in circulating red blood cells (RBCs).

Kapstat contains calcium polystyrene sulphonate an inert cation resin, which is prepared in calcium phase. Calcium polystyrene sulphonate is indicated in hyperkalemia, a condition in which there is increased potassium level in the blood (5. 0 millimoles). Calcium polystyrene sulphonate acts by removing potassium ions from the large intestine lumen (exchange of potassium with calcium).

CAPD system are used for Continuous Ambulatory Peritoneal Dialysis (CAPD). CAPD is a procedure for removing toxic waste products and metabolites normally excreted by the kidneys and for aiding in the regulation of fluid and electrolyte balance. The procedure is accomplished by instilling the peritoneal dialysis fluid into the peritoneal cavity. Toxic substances and metabolites are present in high concentration in the blood, which are removed, from blood into dialyzing fluid, by diffusion process. Dextrose anhydrous in the dialysis fluid is used to produce a solution hyperosmolar to the plasma, creating an osmotic gradient which facilitates fluid removal from the plasma into the peritoneal cavity. CAPD is done manually.

Epotin is recombinant Human erythropoietin Prefilled syringe. Erythropoietin is a glycoprotein hormone produced by the kidney. It is prepared by DNA recombinant technology. Erythropoietin acts on the most primitive precursors or progenitors of erythrocytes by acting on the cell membrane receptors. Erythropoietin stimulates erythrocytic process as well as their maturation and differentiation.

TriSafe is an innovative CAPD fluid with enhanced biocompatibility. TriSafe is available as the world's most acclaimed and accredited complete integrated disconnect CAPD system. TriSafe comprises of one filled bag attached with empty drain bag. TriSafe offers all conventional concentrations of Dextrose Anhydrous (1.36, 2.27, and 3.5% w/v) in single bag.

CAPD is a procedure for removing toxic waste products and metabolites normally excreted by the kidneys and for aiding in the regulation of fluid and electrolyte balance.

Generally CAPD Solution contains Dextrose & all electrolytes in a single bag. So during heat sterilization solution will become cytotoxic due to formation of glucose degradation products. GDPs are toxic in nature & causes infusion pain, cytotoxicity i.e. inhibit cell growth & assault fundamental life processes of the cells. GDPs are also responsible for impaired ultrafiltration capacity of peritonium & inhibition of host defense response.

In Trisafe, there are 3 compartments ( A,B, & C). The glucose is separated form electrolytes & it is sterilized at lower PH. All these help in minimizing or avoiding GDPs formation.

A 3-in-1 combination pack providing proteins, carbohydrates, and lipids simultaneously with the added benefits of convenience, quality, and economy.

Convenience because of its presentation in EnerG bag providing the benefit of further customization as per patient needs. This system is lightweight vis-à-vis the bottle system, thus reducing the chances of breakage.

Quality because of no maillard reaction. The EnerG bag has different compartments for amino acids and dextrose, hence, there are no chances of occurrence of maillard reaction.

Economy because it provides more energy and proteins at less cost.