Comber Engineering Private Limited

The Pharmadry Horizontal Vacuum Paddle Dryer was primarily developed for the drying of pharmaceutical ingredients and fine chemicals. Besides its low capital investment costs major advantages of this Dryer are its short cycle times, the prevention of contamination by foreign matter, its simple operation and easy validation as well as facilitated cleaning and inspection. The Dryer is particularly suited to be used in clean rooms and for sterile applications. The machines are designed and built per cGMP and FDA guidelines. The important features of the PHARMADRY are:- Cylindrical, horizontal vessel with flat welded back cover and a hinged flat front door opening up over the entire vessel diameter. With the door open, the internals of the machine are fully accessible for cleaning and inspection purposes. All surfaces in contact with the product such as the vessel, back cover, front door, agitator and vapour Filter are heated, providing very efficient heat exchange. The cylindrical vessel, the back cover, the front door and the agitator are machined to assure the smallest possible tolerances between agitator and vessel walls. - Smallest possible tolerances also permit good heat exchange and prevent product adherence. - All internal surfaces are mirror polished, to improve the flow behavior of powdery products, the prevention of micro deposits as well as to facilitate cleaning. - The agitator is installed at the back of the Dryer, supported on one side of the vessel only. - The agitator is designed to meet the requirements of this particular Dryer type to assure good and even mixing action throughout the Dryer volume, also in reverse operation, to provide good discharging characteristics and at the same time reduce friction on the product to a minimum to prevent local overheating as well as to prevent directional thrust or local product compression.

The TERMOMIX Horizontal Paddle Dryer can be used in vacuum as well as in pressure applications and was developed for use in heavy industrial processes. The Paddle Dryer is applied as mixer, reactor and Dryer, where process steps under vacuum / pressure and with heating / cooling may be performed in succession or simultaneously. The TERMOMIX is a versatile and very strong machine designed for the highest requirements in functionality,reliability and longevity. The machines meet the following requirements: Highly efficient agitator system with good and even mixing action throughout the Dryer volume avoiding preferential flow patterns and dead areas. High heat transfer rate. Discharge of the dried product by the agitator. Safe processing of hazardous products without endangering operating personnel or the environment. The important features of the TERMOMIX are: * Cylindrical, horizontal pressure vessel, with bolted or welded dished covers. * All surfaces in contact with the product such as the vessel, covers, agitator and Vapor Filter are heated, providing very efficient heat exchange. * The agitator is supported on both sides of the vessel. * The agitator is designed to meet the requirements of this particular Dryer type to assure good and even mixing action throughout the Dryer volume, also in reverse operation, to provide good discharging characteristics and at the same time reduce friction on the product to a minimum to prevent local overheating as well as to prevent directional thrust or local product compression. * Speed adjustable using frequency converters with electric drives or control valves with hydraulic drives. * Sealing of the agitator shaft with double mechanical seals or stuffing boxes. * Mechanical seals: The mechanical seals are installed on the covers, dry or wet running mechanical seals may be installed. Advantages of the mechanical seals:- * Better final vacuum. * No hazardous leakage or emissions.

High drying efficiency is achieved with the constant up and down movement of the agitator through the entire cake thickness, thus providing good mixing and preventing product adhesion on the vessel walls. The unique agitator design provides for operational flexibility without the need for a chopper. Excellent clean ability, with the top drive design without chopper not requiring any seals in the product area. The conical bottom design in combination with smallest agitator to vessel wall clearances allow for optimal product discharge with minimal product hold-up. Good clean ability and inspection access with the openable vessel bottom

The machines meet the following requirements: * Very easy cleaning and inspection. * Highly efficient and versatile, also for difficult products. * Short drying times. * No cross-contamination. * Minimal product hold-up after discharging. * Simple operation and easy validation. * Very efficient and even mixing of the entire product mass. * No product adherence to the vessel wall and base, no dead zones. * Maximum possible heat exchange rate. * Vacuum to 1 mbar. * Agitator support. * On the dished top head, without any seals in the product area. * Agitator with vertical movement allows agitation of the total product volume and thus critical phases during the drying process can be avoided. The machines are designed and built as per cGMP and FDA guidelines. A quality performance related machine according to cGMP and FDA rules.

The Machines Are Used for:- * Discontinuous solids / liquid separation. Vacuum drying of the product whereby all * Efficient cake washing, including reslurrying. processes are performed in one machine. The machines are designed and built as per cGMP and FDA guidelines. The machines are suitable for the processing of a wide variety of products and have been optimized for frequent changes in production as well as for sterile operations. A glass-lined version is available for highly corrosive products. The special agitator design permits the filtration, washing and drying operations all to be performed in a single machine, making the PRESSOFILTRO a truly universal machine. Performing all operations in an enclosed system assures constant product quality, simple validation as well as the required operational safety and environmental soundness.