Green Signal Bio Pharma Private Limited

BCG or Bacillus Calmette Guerin is a vaccine used for prevention of Tuberculosis(TB) in humans since 1921.Approximately 100 million children were administered (vaccinated) with BCG in almost 170 countries in the world.The BCG vaccine is prepared from a strain of attenuated,live tuberculosis bacilli—Mycobacterium Bovis. That has lost it’s virulence in humans by being specially cultered in an artificial medium for years.The bacilli have retained enough strong antigenecity to become an effective Vaccine for the prevention of tuberculosis in human beings.

BCG Vaccine is one of the most widely used vaccines in the world. Its efficacy against TB meningitis in the pediatric age-group is established; but its efficacy against pulmonary TB is appears to be variable. Many countries use BCG for prevention of TB. But a few countries like U.S, they do not use BCG for routine vaccination. This is probably because they believe in detecting the active disease by a reliable Mantoux test, instead of practicing the routine vaccination against a relatively rare condition i.e, the incidence of TB is very low.

Bacillus Calmette-Guérin (BCG) is a live freeze dried preparation from Danish strain 1331. Freeze Dried BCG 40 mg is a therapeutic drug against cancer chemotherapy especially Carcinoma of Urinary Bladder. Intravesical chemotherapy reduces short-term tumor recurrence by about 20%, and long-term recurrence by about 7%, but has not reduced progression or mortality. Presently, BCG immunotherapy remains the most effective treatment and reduces tumor recurrence, disease progression, and mortality.

Bladder cancer is the fourth most common cancer among men and the eighth most common cancer among women. The therapy is used in superficial transitional cell bladder cancer for three reasons – to treat carcinoma in-situ, to reduce the number and frequency of recurrent tumors and to prevent disease progression