Toxicological Study

Acute toxicity study aim to determine toxic manifestation of the test substances that occurs when animal exposed to one or more dose of test substance with in 24 hrs. This study provides information regarding the possible health hazards which are likely to occur, if human are exposed to a single dose of a substance. This way, can help determine the level of usage of that substance.

Following routes of exposure for acute toxicity:

• Oral
• Dermal
• Inhalation
• Intravenous
• Intraperitoneal
• Other protocol specified route.

Sub-Acute Toxicity

Sub-acute toxicity study aim find out toxic effect of drug on repeated exposure and also provide the valuable information i.e. delayed effect which may result due to the cummulative effect of the chemicals on the tissues or other biochemical mechanisms. This study also helps in establishing the level of the safe usage of a
compound.
The following routes are commonly used:

• Oral
• Dermal
• Inhalation
• Intravenous
• Intraperitoneal
• Other protocal specified route

The period of exposure may vary from 14 days to 90 days


Chronic Toxicity Studies

Chronic toxicity aim to characterize the effect of test compound following repeated exposure for prolong peroid of time in a mammalion species. The route of exposure are most likely the ones to which the human are exposed to that particular compound.

This is the surface effects of a compound on the body surface(skin and mucous membrance) is important because accidental contamination is always a possibility, hence to check any such effects the following studies are performed.

• Mucous membrane irritation
• Skin irritation

Reproductive Toxicity study aim to findout effect of test compound on fertility and reproduction. The many compounds can affect the fertility and reproduction, often in an insidious manner without any overt signs of toxicity. Fertility of males & females can be affected or adverse effects on the developing embryo or fetus may result due to the exposure of chemicals.

We are offering Carcinogenicity & Mutagenicity Study.

 

Carcinogenicity

Main objective of this study is to find out carcinogenicity effect of test compound when exposed for a prolonged period.

Mutagenicity

Adverse effects caused by any chemical / compound on the genetic material of the cells i.e. DNA, or by altering its structure or function can be checked out by :

• In- Vitro method : Ames’s test

• In-Vivo method : Rodent Dominant lethal study Micronucleus study

We care offering Supplementary Toxicity Studies that includes :

• Neurotoxicity studies on Egg laying hens.

• Synergism & Potentiation Studies (Combined effects of various chemicals)

• Schedule Y of Drugs & Cosmetics Act

• For submission to Office of Drug Controller

• General of India , New Delhi

• Regulations of Central Insecticides Board (CIB)

• Gaitonde Committee Protocol

• OECD Guidelines for testing of chemicals

• ICH Guidelines