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Active Pharmaceutical Ingradeints Bulk Drug

Active pharmaceutical Ingradeints Bulk Drug

Indexim International was established in late 2011 in Ahmedabad, Gujarat, India. Since its inception, we are dealing in the supplier exports of most qualitative Active Pharmaceutical Ingredients (APIs) at most competitive rates from Indian GMP approved Manufacturer. Within 2 years of our operation of exports of APIs, we became regular supplier of APIs for many pharmaceutical companies across various countries. The credit for this success goes to each and every employees of Indexim International as well as our API manufacturers from whom we are procuring qualitative APIs at competitive price.

 

Kindly request to contact us for requirement of APIs or bulk drugs.Bosentan

Irinotecan Hcl USP (Total synthesis process)

Misoprostol (1% dispersion in HPMC)                                                  

Topotecan Hcl

Lornoxicam 

Domperidone 

Drotaverine HCL

Duloxetine Hydrochloride

Telmisartan HCL

Terbinafine

Tizanidine

Tramadol HCL

TOLTERODINE TARTRATE

Lenalidomide 

Pralatrexate 

Clopidogrel

Topotecan hydrochloride

 

Voglibose(as per order only)

Atorvastatine

 

Trimethoprim

Albendazole

Montelukast

Saxagliptin, Sitagliptin, Lingagliptin

Balofloxacine

Divalproex Sodium

Valproic Acid, sodium valproate and derivative

Moxifloxacine

Rosuvastatin

EPERISONE HCL and TOLPERISONE HCL

Metronidazole

Mebendazole

Carbamazepine

Tramadol Hydrocloride

Ascorbic Acid ( Vitamin C coated )

Trimethoprim ( TMP )

Cilostazole

Olanzpine

Iron sucrose complex

Adapalene

 

Diacerin and more 

Alpha Keto Leucine Calcium Salt

CAS 51828-95-6
A ketogenic amino acid is an amino acid that can be degraded directly into Acetyl CoA through ketogenesis 

Payment Terms: L/C (Letter of Credit), T/T (Bank Transfer)
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: Ahmedabad
Production Capacity: 10 ton
Delivery Time: with week
Packaging Details: asper

Atorvastatin Calcium

Atorvastatin Calcium

A white to off white crystalline Powder

The IR spectrum of sample should be concordant to that of working standard.

The Retention time of the principal peak obtained with samples should be concordant with that of working standard

Shall give positive test for calcium.

Payment Terms: T/T (Bank Transfer)
FOB Price: 12000 INR
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: Ahmedabad
Production Capacity: 100
Delivery Time: with in week
Packaging Details: drum packing

Cilostazole

Cilostazole

Cilostazol

white crystalline powder,
high purity with good quality at convenient price

 
Product Code: 73963-72-1
Payment Terms: L/C (Leter of Credit), T/T (Bank Transfer), Other
FOB Price: 200
Minimum Order Quantity: 25 Kilogram
Port of Dispatch: Nava seva
Production Capacity: 2tons/month
Delivery Time: 10 days after confirmation of order
Packaging Details: 25 kg HDPE drum


Product Code: 73963-72-1
Payment Terms: T/T (Bank Transfer), Other
FOB Price: 200 USD
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: ahmedabad
Production Capacity: 2 tons
Delivery Time: 10 days after confirmation of order
Packaging Details: 5 kg HDPE drum

Olanzapine

Yellow Crystalline Powder


Product Code: 132539-06-1
Payment Terms: T/T (Bank Transfer), Western Union, Other
FOB Price: 200 USD
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: ahmedabad
Production Capacity: 2tons month
Delivery Time: 10 days after confirmation of order

Dabigatran Etexilate Mesylate

Dabigatran Etexilate Mesylate

Light Yellow Powder


Product Code: 872728-81-9
Payment Terms: T/T (Bank Transfer), Western Union, Other
FOB Price: 11000 USD
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: ahmedabad
Production Capacity: 2tons month
Delivery Time: 10 days after confirmation of order

Voglibose BP/IP

Voglibose BP/IP

Appearance

White crystal or crystalline powder

Identification (by IR)

Should be corresponds

Solubility

Very slightly soluble in water and ethanol, freely soluble in acetic acid

Melting Point

163 - 1680C

pH

9.8-10.4

Payment Terms: T/T (Bank Transfer)
FOB Price: 6600 USD
Minimum Order Quantity: 1 Kilogram
Port of Dispatch: Ahemdabad
Production Capacity: 10 kg
Delivery Time: with in 15 days
Packaging Details: standard

Lafutidine

Lafutidine

white crystalline powder


Product Code: 118288-08-7
Payment Terms: T/T (Bank Transfer), Western Union, Other
FOB Price: 3000 USD
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: ahmedabad
Production Capacity: 2tons month
Delivery Time: 10 days after confirmation of order
Packaging Details: as per customer requirement

Bosentan Monohydrate

Bosentan Monohydrate

white powder


Product Code: 157212-55-0
Payment Terms: T/T (Bank Transfer), Western Union, Other
FOB Price: 11000 USD
Minimum Order Quantity: 10 Kilogram
Port of Dispatch: ahmedabad
Production Capacity: 2tons month
Delivery Time: 10 days after confirmation of order

Montelukast Sodium

Montelukast Sodium

Montelukast is used for a number of conditions including asthma, exercise induced bronchospasm, allergic rhinitis, and urticaria.It is mainly used as a complementary therapy in adults in addition to inhaled corticosteroids, if they alone do not bring the desired effect.

Sitagliptin Phosphate

Sitagliptin Phosphate

Sitagliptin  is an oral a antihyperglycemic (antidiabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class

Losartan Potassium

Losartan Potassium

Losartan  is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure
CAS 114798-26-4
 

Diacerein

Diacerein

Diacerein (INN), also known as diacetylrhein, is a drug used in the treatment of osteoarthritis.[1] It works by inhibiting interleukin-1. A 2005Cochrane review found diacerein to be slightly, but significantly, more effective than placebo in improving pain and slowing the progress of osteoarthritis in the hip.[2]

Alpha Keto Phenyl Alanine Calcium Salt

A ketogenic amino acid is an amino acid that can be degraded directly into Acetyl CoA through ketogenesis.

CAS 51828-93-4 

Alpha Keto Valine Calcium Salt

A ketogenic amino acid is an amino acid that can be degraded directly into Acetyl CoA through ketogenesis.

Alpha Keto Isoleucine Calcium Salt

ketogenic amino acid is an amino acid that can be degraded directly into Acetyl CoA through ketogenesis. This is in contrast to the glucogenic amino acids, which are converted intoglucose. Ketogenic amino acids are unable to be converted to glucose as both carbon atoms in the ketone body are ultimately degraded to carbon dioxide in the citric acid cycle.

Domperidone

Domperidone

White to almost white powder

 

Practically insoluble in water, soluble in dimethyl  formamide, slightly soluble in methanol and in ethanol.

Trimethoprim

Trimethoprim

Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary 
Trimethoprim can be prepared from 3,4,5-trimethoxybenzaldehyde, 3-ethoxypropionitrile, and guanidine 

Irinotecan Hcl USP

Irinotecan Hcl USP

Irinotecan Hydrochloride Trihydrate belongs to a group of chemotherapy drugs and these are generally known as topoisomerase inhibitors. It is used for the treatment of colon and rectal cancers. Numerous elements are necessary for the cell division. Irinotecan inhibits the growth of cancer cells by slowing their growth and preventing the development of elements needed for the cell to grow. This medication has side effects such as lowering of platelet count, severe diarrhoea, nausea and vomiting.

 

CAS number 100286-90-6 Yes

ATC code L01XX19

PubChem CID 60838

DrugBank DB00762

ChemSpider 54825 Yes

UNII 7673326042 Yes

KEGG D08086 Yes

ChEMBL CHEMBL481 Yes

Chemical data

Formula C33H38N4O6 e

Mol. mass 586.678 g/mol (Irinotecan)

623.139 g/mol (Irinotecan hydrochloride)

677.185 g/mol (Irinotecan hydrochloride trihydrate))

 

Irinotecan Hcl USP (Total synthesis process)

USDMF , EDMF available.

Product Code: Irinotecan

Misoprostol (1% Dispersion In HPMC)

Misoprostol (1% dispersion in HPMC)

Misoprostol is a synthetic prostaglandin E1 (PGE1) analog that is used for the prevention of nonsteroidal anti-inflammatory drug

1,Product:Misoprostol 
2,CAS:59122-46-2 
3,Appearance:White to off-white powder 
4,Excellent quality 

Product Information
Product:           Misoprostol
CAS:                59122-46-2
MF:                  C22H38O5
MW:                382.54
EINECS:            N/A
Melting Point:    261-263 °C
Storage Temp.: -20 °C

Items Specification Results
Characteristics White to off-white powder Confirms
Identification HPLC & UV confirms to standard Confirms
Solubility Clear Confirms
Water, % ≤5.0 1.81
Individual impurities, %
A-type misoprostol ≤0.30 0.14
B-type miprostol ≤0.30 N.D.
Norsoprostol ≤0.10 N.D.
8-epimisoprostol ≤0.30 0.08
12-epimisoprostol ≤1.0 0.24
Any other single impurity ≤0.50 0.07
Total impurities, % ≤2.0 0.53
Residue on Ignition, % ≤1.50 0.56
Heavy metals, ppm ≤10.0 Confirms
Assay, % 0.9~1.10 1.05

 


Topotecan Hcl

Topotecan Hcl

  • Topotecan (trade name Hycamtin) is a chemotherapeutic agent that is a topoisomerase inhibitor. It is a water-soluble derivative of camptothecin. It is used in form of the hydrochloride to treat ovarian cancer and lung cancer, as well as other cancer types. 
  • Chemical formula: C23H23N3O5.HCl
  • Synonyms: 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, hydrochloride (1:1), (4S)-
  • Molecular weight: 457.91 
  • Melting Point: 213-218°C
  • Assay : 99 %
  • Boiling Point: 782.9 °C at 760 mmH
  • Flash Point: 427.3 °C
  • Appearance: white crystalline solid
  • Package : 5/10/25kg/fiber drum

Pralatrexate API

Pralatrexate API

10-Propargyl-10-deazaaminopterin 
CAS: 146464-95-1 
MF: C23H23N7O5 
MW: 477.47

 

 

Specifications

10-Propargyl-10-deazaaminopterin 
CAS: 146464-95-1 
MF: C23H23N7O5 
MW: 477.47

 

Product Name: 10-Propargyl-10-deazaaminopterin
Synonyms: Pralatrexate;N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid;10-Propargyl-10-deazaaminopterin;L-Glutamic acid, N-(4-(1-((2,4-diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-;Pdx;Unii-A8Q8I19Q20;N-(4-{1-[(2,4-diaMinopteridin-6-yl)Methyl]but-3-yn-1-yl}benzoyl)-L-glutaMic acid;Folotyn
CAS: 146464-95-1
MF: C23H23N7O5
MW: 477.47
EINECS:  
Mol File: 146464-95-1.mol

 

 

Voglibose 83480-29-9

Voglibose 83480-29-9

Specifications

Product Name: Voglibose 
CAS No.: 83480-29-9 
Usage: Antidiabetic

Chemical Name 5-(1,3-Dihydroxypropan-2-ylamino)-1-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol
CAS Number 83480-29-9
Molecular Formula C10H21NO7
Molecular Weight 267.13
Packing Tin
Capacity Production upon order
Storage Keep tightly closed in light-resistant containers
Application Voglibose is an used for lowering post-prandial blood glucose levels in people with .

 

 

Items Specification
Appearance White crystals or crystalline powder
Identification Meets the requirements
Melting Point 163.0 ~ 168.0
Specific Rotation +45.0°~ +48.0°
PH 9.5 ~ 10.5
Water ≤0.5%
Residue on Ignition ≤0.1%
Heavy Metals ≤10ppm
Related Substances ≤0.2%
Assay ≥99.5%
Standard Factory Standard

Tolterodine Tartrate

Tolterodine Tartrate

Tolterodine  is a chiral drug , which as a specific and competitive antagonistat muscarinic receptors in patients with the syndrome of overactive bladder is used.
The active ingredient is for symptomatic treatment increased urinary urgency (sudden urge to pass urine) in patients with increased urinary frequency (frequent urination), imperative, urge incontinence (sudden loss of control urination), as the syndrome of overactive bladder can occur used . [4]

ree name Tolterodine
Other Names
  • R ) -2 - [3 - [bis (1-methylethyl)-amino] - 1-phenylpropyl]-4-methyl phenol
  • R ) -2 - [α-[Diiospropylamino) ethyl] - benzyl] - p -cresol
  • (+) - ( R ) -2 - [α-[Diiospropylamino) - ethyl]-benzyl]-4-methyl phenol
Formula
  • 22 H 31 NO (tolterodine)
  • 22 H 31 NO · C 4 H 6 O [· tolterodine tartrate]
CAS number
  • 124937-51-5 (tolterodine)
  • 124937-52-6 [tolterodine · ( R , R )-tartrate]
PubChem 60774
ATC code

G04 BD07

DrugBank APRD00146
 

Azithromycin Dihydrate

Azithromycin Dihydrate

Mol File:

83905-01-5.mol

mp 

113-115°C

storage temp. 

Store at -20°C

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

83905-01-5(CAS DataBase Reference)

EPA Substance Registry System

1-Oxa-6-azacyclopentadecan- 15-one, 13-[(2,6-dideoxy-3-C-methyl- 3-O-methyl-.alpha.-L-ribo- hexopyranosyl)oxy]-2-ethyl- 3,4,10-trihydroxy-3,5,6,8, 10,12,14-heptamethyl-11-[[ 3,4,6-trideoxy-3-(dimethylamino)-. beta.-D-xylo-hexopyranosyl] oxy]-, (2R,3S,4R,5R,8R,10R,11R,12S, 13S,14R)-(83905-01-5)

Chemical Properties

White Crystalline Powder

Usage

Semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial

Biological Activity

Macrolide antibiotic. Inhibits 50S ribosomal subunit formation and elongation at transpeptidation step in gram-positive and gram-negative organisms. Orally active with improved pharmacokinetics over erythromycin in mouse models.

Atorvastatin Calcium 134523-00-5

Atorvastatin Calcium 134523-00-5

Name:atorvastatin 
Cas No:302962-49-8 
MF:C33H35FN2O5 
Use:reduce LDL cholesterol 
Appearance:white powder

Name:atorvastatin

General introduction:Atorvastatin  is a member of the drug class known as statins, used for lowering blood cholesterol. It also stabilizes plaque and prevents strokes through anti-inflammatory and other mechanisms. Like all statins, atorvastatin works by inhibiting HMG-CoA reductase, an enzyme found in liver tissue that plays a key role in production of cholesterol in the body.


Atorvastatin was first synthesized in 1985 by Bruce Roth. With 2008 sales of US$12.4 billion, Lipitor was the top-selling branded pharmaceutical in the world. US patent protection is scheduled to expire in June 2011

Indications:

Hypercholesterolemia (heterozygous familial and nonfamilial) and mixed dyslipidemia (Fredrickson types IIa and IIb) to reduce total cholesterol, LDL-C,[5] apo-B,[6] Triglycerides[7] levels, and CRP as well as increase HDL levels.

Moxifloxacin EP/BP

Moxifloxacin EP/BP

Moxifloxacin is a fourth-generation synthetic fluoroquinolone antibacterial agent developed by Bayer AG (initially called BAY 12-8039). It is marketed worldwide (as the hydrochloride) under the brand names AveloxAvalox, and Avelon for oral treatment. In most countries, the drug is also available in parenteral form for intravenous infusion. Moxifloxacin is also sold in an ophthalmic solution (eye drops) under the brand names VigamoxMoxezafor the treatment of conjunctivitis (pink eye).

Tadalafil API

Tadalafil API

1.Tadalafil is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction (ED) under the name Cialis; and under the name Adcircafor the treatment of pulmonary arterial hypertension.

2.molecular formula: C22H19N3O4

3.Cas#: 171596-29-5

4. molecular weight:389.404

 

 

 

 

Name Tadalafile powder
Appearence White crystalline powder
Cas

171596..29..5

Assay ≥99.5%
Solubility Insoluble in water or alcohol, soluble in Acetic acid, ethyl ester
Melting point

300-303°C

Loss on drying

≤0.5%

Heavy Metal

≤50ppm

Specific rotation

[a]20D=+70-72o(C=1.00,CHCl3)

Dosage

15- 25mg

Onset time

30 minites

Grade

Pharmaceutical Grade

Package 1 kg in an aluminum foil bag, 25kg/drum.

 

Dabigatran Etexilate Mesylate

Dabigatran Etexilate Mesylate




Specifications

1.Dabigatran 
2.872728-81-9 
3.Assay no less than 99% 
4.Usually have it in stock 
5.Can supply its intermediates

1. Dabigatran etexilate mesylate

2.CAS NO.: 872728-81-9
3.Assay no less than 99%
4.Usually have it in stock
5.Also can supply its intermediates

Product :  Dabigatran Etexilate Mesylate

 

Sr.No.

Test

Specification

1

Description

Light Yellow Powder

2

Solubility

Freely soluble in Ethanol , Methanol

Insoluble in Ethyl acetate, Acetone, Water

3

Water by KF(%w/w)

Not more than 0.50

 

4

Chormatogrpahic purity

(By HPLC, %Area)

 

  1. i.                   Any individual impurity

 

  1. ii.                 Total impurities

 

Not less than 99%

 

Rosuvastatin API 287714-41-4

Rosuvastatin API 287714-41-4

Name:rosuvastatin 
cas no:287714-41-4 
formula:C22H28FN3O6S 
use:treatment of high cholesterol 
appearance:white powder

1.Name:rosuvastatin

 

2.cas no:287714-41-4

 

3.formula:C22H28FN3O6S

 

4.use:treatment of high cholesterol

 

5.appearance:white powder

 

Nystatin

Nystatin

Nystatin (originally named Fungicidin) is a polyene antifungal medication to which many molds and yeast infections are sensitive, including Candida. Due to its toxicity profile, there are currently no injectable formulations of this drug on the US market.[1] However, nystatin may be safely given orally as well as applied topically due to its minimal absorption through mucocutaneous membranes such as the gut and the skin

Product Code: Nystatin

Adapalene

Adapalene

Iron-Sucrose Complex

Iron-Sucrose Complex

Agomelatine & Ites Intemediates

Agomelatine & Ites Intemediates

Cildepine

Cildepine

Rasageline

Rasageline

To,Indexim International

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