Gabapentin is a white to off-white crystalline solid with a pka1 of 3.7 and a pka2 of 10.7. It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05m phosphate buffer)

We offer gabapentin drug that is widely used for depression, mania and anxiety. It is a latest anticonvulsant and is also effective in various diseases such as Ibromyalgia, Tardive Dyskinesia and other. These are also prescribed for psychiatry purpose to treat mood and anxiety disorders.

•  TECHNICAL NAME: 1-(aminomethyl) cyclohexaneacetic acid


•  MOLECULAR FORMULA: C9H17NO2


•  MOLECULAR WEIGHT: 171.24.


•  THEORITICAL CATAGORY: Anticonvulsant / Antiepeleptic


•  CAS NO: 60142-96-3


•  SPECIFICATION: In-house


•  H.S.CODE: 30049081
  
•  WATER CONTENT: (S) - NMT 0.3% w/w (R) - 0.10%


•  RESIDUE ON IGNITION: (S) - NMT 0.1% w/w (R) - 0.082%


•  HEAVY METALS: (S) - NMT 0.002% w/w (R) - Less than 0.002%


•  pH: (S) - Between 6.5 to 7.5 (R) : 7.14


•  LIMIT OF CHLORIDE: (S) - NMT 0.01% w/w (R) - 80 ppm


•  RELATED SUBSTANCES(by HPLC):

a) Impurity at RRt about 0.5: (S) - NMT 0.1% w/w (R) - Not detected
b) Gabapentin related Compound A: (S) - NMT 0.1% w/w (R) - 0.032%
c) Individual impurity: (S) - NMT 0.3% w/w (R) - 0.032%
d) Total impurity: (S) - NMT 0.5% w/w (R) - 0.07%

•  ASSAY BY HPLC (on dried basis): (S) - 98.0% to 102.0% w/w (R) - 99.65%


•  ORGANIC VOLATILE IMPURITIES & RESIDUAL SOLVENT:

a) Acetone : (S) - NMT 5000 22/7g/g (R) - 2782 22/7 g/g
b) Methanol: (S) - NMT 3000 22/7g/g (R) - 852 22/7 g/g
c) Methylene Chloride: (S) - NMT 600 22/7g/g (R) - 483 22/7 g/g

WE CAN ALSO OFFER GABAPENTIN AS PER USP SPECIFICATION:

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It is freely soluble in water and both basic and acidic aqueous solutions. The log of the partition coefficient (n-octanol/0.05M phosphate buffer) at pH 7.4 is -1.35 The pregablin drug offerd by us do not contain mandelic acid, which is present in other forms of this drug. It is a common anticonvulsant and helps in the treatment of neuropathic pain, as an adjunct therapy for partial seizures, anxiety disorder.It slows the impulses of brain that is a major cause of seizures. It is also effective in chronic pain, spinal cord injury and fibromyalgia disorder. Pregabalin is a white to off - white, crystalline solid with a pKa1 of 4.2 and a pKa2 of 10.6.

• TECHNICAL NAME: S-3-(aninomethyl)-5-methylhexanoic acid
• MOLECULAR FORMULA: C8H17NO2
• MOLECULAR WEIGHT: 159.23
• THEORITICAL CATAGORY: Anticonvulsant /Antiepeleptic
• CAS NO: 148553-50-8
• SPECIFICATION: In-house
• H.S.CODE: 30049082
• WATER CONTENT BY KF: (S) - NMT 2.0% w/w (R) - 0.15%
• RESIDUE ON IGNITION: (S) - NMT 0.20% w/w (R)-0.08%
•  SPEICIFIC OPTICAL ROTATION (C=1% w/v in water):
(S) - Between 9.0º to 13.0º (on anhydrous basis) (R) - 10.50º
• HEAVY METALS: (S) - NMT 20 ppm (R) - Complies
•  RELATED SUBSTANCES: Single Max Imp: (S) - NMT 1.0% (R) - 0.28%
Total Impurities: (S) - NMT 2.0% (R) - 0.35%
•  ASSAY BY TITREMETRY (on anhydrous basis): (S) - NLT 98.0% & NMT 102% (R) - 99.75%

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Ondansetron Hcl dihydrate is a white to off-white powder that is soluble in water & in alcohol, soluble in methanol, slightly soluble in isopropyl alcohol & in dichloromethans, very slightly soluble in acetone in chloroform and in ethyl acetate.

• TECHNICAL NAME: (3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)]-1, 2, 3, 9 - tetrahydro - 4H - carbazol - 4 - one hydrachloride dihydrate
• MOLECULAR FORMULA: C18H19N30•Hcl•2H2O
• MOLECULAR WEIGHT: 365.86 g/mol
• THEORITICAL CATAGORY: Antineusia / Antiemetic
• CAS NO: 103639-04-9
• SPECIFICATION: In – house
• H.S.CODE:
•  WATER CONTENT BY KF: (S) - Between 9.0% and 10.5% (R) - 9.8%
•  RESIDUE ON IGNITION: (S) - NMT 0.1% w/w (R) - 0.09%
•  LIMIT OF ONDANSETRON RELATED COMPOUND D: (S) NMT 0.1% w/w (R) Not detected
•  CHROMATOGRAPHIC PURITY METHOD-I (BY TLC): a) Ondensetron related compound B: (S) - NMT 0.4% (R) - Less than 0.4% b) Ondensetron related compound A: (S) NMT 0.2% (R) - Less than 0.2%
•  CHROMATOGRAPHIC PURITY METHOD - II (BY HPLC): a) Ondansetron related compound C: (S) NMT 0.2% (R) - Not detected b) Imidazole: (S) - NMT 0.2% (R) - 0.08% c) 2 - Methyl imidazole :(S) - NMT 0.2% (R) - Not detected d) Ondansetron related Compound A: (S) - NMT 0.2% (R) - 0.18% e) Unknown highest impurity : (S) - NMT 0.1% (R) - 0.09% f) Total impurities : (S) - NMT 0.5% (R) - 0.36%
•  ASSAY BY HPLC: (S) - NLT 98.0% & NMT 102% of 18H19N3) •HCL calculated on the anhydrous basis (R) - 99.58%
•  RESIDUE SOLVENTS (BY GC) a) Isopropyl alcohol : (S) - NMT 2000 ppm (R) - Not detected b) Ethyl acetate : (S) - NMT 2000 ppm (R) - Not detected c) Dichloromethane : (S) - NMT 500 ppm (R) - Not detected d) Toluene : (S) - NMT 500 (R) - 99 ppm

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It is a white to off-white powder, which is soluble in tetrahydrofuran, very slightly soluble in ethanol, and practically insoluble in water. Adapalene has actions similar to vitamin A (retinol). It stimulates cell division in the skin and reduces the production of keratin. It aids skin peeling and prevents the formation of acne lesions (comedones). The action of adapalene combats the changes that take place in acne. Adapalene is used in the treatment of mild to moderate acne. It is best suited to dry and fair skin.

•  TECHNICAL NAME: 6 - [3 - (1- adamantyl) - 4 - methoxyphenyl]-
  2-Naphthoic acid


•  MOLECULAR FORMULA: C28H28O3


•  MOLECULAR WEIGHT: 412.53


•  THEORITICAL CATAGORY: Anti-acne


•  CAS NO: 106685-40-9


•  SPECIFICATION: In-house
  
•  H.S. CODE:


•  MELTING RANGE: (S) - Between 318ºC and 326ºC (R)-318ºC - 324ºC


•  LOSS ON DRYING :(S) - NMT 0.50% w/w (R) - 0.30% w/w


•  RESIDUE ON IGNITION :(S) NMT 0.20 % w/w (R) - 0.08% w/w


•  HEAVY METALS :(S) NMT 20 ppm (R) - Complies


•  RELATED SUBSTANCES BY HPLC %:
  a) Single Maximum Impurity : (S) - NMT 0.50% (R) - 0.34%
  b) Total impurity :(S) NMT 1.00% (R) - 0.49%


•  ASSAY BY HPLC (on dried basis): (S) - NLT 98.0% & NMT 102.0% w/w (R) - 99.30%


•  RESIDUE SOLVENTS :
  a) Ethyl acetate (ppm) : (S) - NMT 3000 (R) - Complies
  b) Tetrahydrofuran (ppm) : (S) - NMT 720 (R) - Complies
  c) Dichloromethane (ppm) : (S) - NMT 600 ppm (R) - Complies
  d) Methanol (ppm) : (S) - NMT 1000 (R) - Complies
  e) Acetone (ppm) : (S) - NMT 5000 (R) - Complies

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 Lamotrigine, an antiepileptic drug (AED) of the phenyltriazine class, is chemically unrelated to existing antiepileptic drugs. Lamotrigine is a white to pale cream-colored powder and has a pKa of 5.7. Lamotrigine is very slightly soluble in water (0.17 mg/mL at 25ºC) and slightly soluble in 0.1 M Hcl (4.1 mg/mL at 25ºC) Lamotrigine is mainly prescribed for epilepsy. It is also effective as an additional therapy for treating Primary Generalized Tonic-Clonic (PGTC) seizures, in children and adolescents. It is effective in partial seizures, primary and secondary tonic-clonic seizures, and seizures, which are caused in Lennox-Gastaut syndrome. It has very loess side effects and blood monitering during usage is also not required.

•  TECHNICAL NAME : 3, 5 - diamino - 6 - (2, 3 - dichlorophenyl)-1, 2, 4-triazine


•  MOLECULAR FORMULA: C9H7N5Cl2


•  MOLECULAR WEIGHT: 256.09


•  CAS NO: 84057-84-1


•  SPECIFICATION: In-house


•  H.S. CODE : 30049081
  
•  IDENTIFICATION :
  (S) - IR Test (R) - Complies
  (S) - U.V. TEST OF 0.0025% ON 309 2NM (MAX) (R) - Complies
  (S) HPLC: The Ret. Time of Principal peak on chromatograph should match with the time of standard sample (R) - Complies


•  MELTING POINT : (S) 216º to 218ºC (R) - 217º to 218ºC


•  LOSS ON DRYING : (S) - NMT 0.5% (R) - 0.26%


•  RESIDUE ON IGNITION :(S) NMT 0.1% (R) - 0.070%


•  HEAVY METALS : (S) - NMT 20 ppm (R) - Complies


•  RELATED SUBSTANCE : (S) - Single imp NMT 0.2% (R) - Complies (S) Total imp NLT 0.5% (R) - Complies
  
•  ASSAY : (S) It contains NLT 98.0% & NMT 102% on dry basis (R) - 99.36%

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An off white to greenish white powder, solule in DMF.

•  TECHNICAL NAME: Hydrazine carboxidazole 2 - [cyano (2, 3 - dichlorophenyl)]methane OR Hydrazine Carboximidamide 2[Cyano (2, 3 - Dichlorophenyl)] methane OR 2-Cyano [(2, 3 - Dichlorophenyl) methylene] hydrazine carboximidamide
•  MOLECULAR FORMULA: C9H7Cl2N5
•  MOLECULAR WEIGHT: 256.09
•  THEORITICAL CATAGORY: Anticonvulsant/Antiepeleptic
•  CAS NO: 84689-20-3
•  SPECIFICATION: In-house
•  H.S. CODE :
•  MELTING POINT :(S) - 165ºC to 185ºC (R) - 172ºC to 177ºC
•  MOISTURE CONT. : (S) - NMT 0.5% (R) - 0.26%
•  RESIDUE ON IGNITION : (S) - NMT 0.1% (R) - 0.08%
•  HEAVY METALS : (S) NMT 10 ppm (R) - Complies
•  ASSAY BY TITRATION : (S)-NLT 97.00% (R) - 99.58%

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It is white to off white csystalline powder, soluble in methanol. .

•  TECHNICAL NAME: 2, 3, Dichloro benzoyl Nitrile
•  MOLECULAR FORMULA: C8H3Cl2N0
•  MOLECULAR WEIGHT: 200
•  THEORITICAL CATAGORY: Anticonvulsant / Antiepeleptic
•  CAS NO: 77668-42-9
•  SPECIFICATION: In-house
•  H.S. Code :
•  IDENTIFICATION : a) IR absorption : (S) - IR absorption spectrum of sample should be concordant with that of working standard (R) - Complies b) GC : (S) - Retention time of sample & working standard should be same in method for chromatographic purity by GC (R) - Complies
•  MELTING RANGE : (S) 56ºC - 62ºC (R) - 58ºC - 62ºC
•  LOSS ON DRYING AT 40ºC UNDER VACUUM (200mm-300mm) FOR 2 HRS. : (S) - NMT 0.5% (R) - 0.25%
•  MOISTURE CONTENT : (S) - NMT 0.2% (R) - 0.1%
•  CHROMATOGRAPHIC PURITY BY GC : a) 2,3-dichlorobenzoyl Nitrile : (S) NLT 97% (R) - 99.61% b) 2,3-dichlorobenzoyl acid : (S) - NMT 2% (R) - 0.09% c) Total impurities (S) - NMT 3% (R) - 0.39%

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