Indiamart
Nishka Labs
Hyderabad, Andhra Pradesh

Pharmaceutical Testing Service

We are a leading service provider for the Pharmaceutical Testing Service which includes services like Formulation Research & Pharmacology since 2010

Formulation Research

Formulation Research

Being an established service providing organization we offer our clients complete solution for Formulation Research (Pharmaceutics). To offer maximum benefits to our clients, we effectively utilize our management skills. With the help of our state-of-art facilities, we are able to offer our clients services for Formulation development, Analytical Method Development and Physical & Chemical Characterization studies. Expert Analytical Research & Development group of our organization are highly skilled and experienced, and enable us to meet the precise demands of our clients..

 

We Develop:

 

  • Liposomal Formulations

  • Microsphere Formulations

  • Transdermal Patches

  • Emulsions

  • Sustained Release Suspensions &

  • Ointments.

Pharmacology

Pharmacology

Pharmacology is the branch of medicine and biology concerned with the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that effect normal or abnormal biochemical function.

 

NISHKA Labs developed its own Animal House facility for conducting Non-GLP studies. We have a team of experts in developing new molecules for any therapeutic category. We can design and execute any model of your choice in consultation with you for any therapeutic category. NISHKA Labs has good experience in supporting clients with excellence in the management of preclinical studies. The pharmacological services are supported by dedicated pathology group and laboratory animal specialties.

 

  1. DMPK Studies (Drug Metabolism & Pharmacokinetic)

  2. Efficacy Studies

  3. Toxicology Studies

 

1. DMPK Studies (Drug Metabolism & Pharmacokinetic)

 

i. ADME Studies (Absorption, Distribution, Metabolism & Excretion)

ADME Studies provide valuable insight into a drug’s in-vivo profile as well as a preview of what may be observed clinically, we offer facility for non GLP studies. Experienced staff & dedicated team are involved in all aspects of study conduct to ensure all essential information is properly analyzed.

ii. PK Studies(Pharmacokinetic)

NSHKA Labs has successfully completed 40 academic projects related to Pharmacokinetic (PK) studies, including drug half life, Bio-distribution, Bio-availability, Bio-equilance & Safety evaluation. We offer Bio analytical methods development & Validation to indentify test articles, Metabolites & Degradation products in blood, Urine & other biological fluids or Tissues.

 

2. Efficacy Studies

 

  • in-vivo Diabetes

  • in-vivo Choleterol Lowering

  • in-vivo Antiulcer

  • in-vivo Anticancer

  • in-vivo Antioxident

  • in-vivo Immuno Modulatory

 

3. Toxicology Studies

 

A comprehensive range of preclinical models which simulate the toxicities of several therapeautic agents observed in preclinical and clinical use. We carry out non GLP safety studies as per the protocols.

 

i. Mammalian Toxicity Studies

 

  • Carcinogenicity.

  • Toxicokinetics

  • Single dose (Acute) toxicity

  • LD 50 & maximum tolerated dose determination.

  • Endotoxin Test

  • Skin Sensitization

  • Skin Irritation / Corrision

  • Eye Irritation / Corrision

 

ii. Genetic Toxicity Studies.

 

  • AMES Test

  • Microneucleus Test

  • Chromosome Aberration

Analytical Research

Analytical Research

NISHKA Labs provides in depth analytical services to support your research project. Being a client centric organization, we are engaged in offering services for Analytical Research to our valued clients. We use latest implementation methods and technologies to render these services to our clients and ensure our clients for reliability and authenticity level of our services. Enriched with vast industry experience, we are able to meet the exact specifications of our clients.

 

The services include

 

  • Determination of Melting point, Excipient Compatibility studies by DSC / DTA / TGA.

  • Loss of weight by TGA.

  • Crystalinity & Polymorphs are identified and quantified with the aid of XRD/DSA.

  • Impurities / Metabolite are also identified & quantified using highly sensitive instruments like LC-MS/MS.

  • Organic impurities and residual solvents shall be estimated using high sensitive Gas Chromatograph.

  • Isomers are separated and quantified using Chiral HPLC.

  • Inorganic impurities shall be estimated using Atomic Absorption Spectrophotometer.

 

HERBAL DRUG RESEARCH

 

  • Identification, Isolation and characterization of therapeutically active compounds in herbs /poly herbal compounds through

  • HPLC

  • LCMS / MS

  • HPTLC

  • NMR / C13 NMR

  • FTIR

  • Finger Printing (HPLC, LCMS/MS etc)

  • Pharmacognestic and Photochemical studies

  • Specification Development and Standardization of Herbal extracts.

  • Qualitative analysis of herbal products

  • Quantitative analysis of herbal products

  • Impurity / Compound isolation using column & semi-preparative HPLC.

Microbiology Studies

Microbiology Studies

Microbiology Studies

 

  • Biochemical characterization of microbial strains

  • Pathogen detection in products

  • Antimicrobial drug screening

  • Antibiotic efficacy testing

  • Identification and purification of antibiotic/enzyme producing microbes

  • Preservative efficacy testing (PET)

  • Quality control tests (TMC, TFC, Sterility test etc.)

  • Microbiological assays of enzymes and vitamins

 

Molecular Biology

 

  • Gene expression studies by RT-PCR method

  • RAPD and RFLP analysis

  • Protein expression, purification and analysis

 

Quality Control Services

 

  • Microbiological analysis of products (TMC,TFC etc)

  • Preservative efficacy testing (PET)

  • Bacterial endotoxin test (BET) in parental prepatations.

  • Sterility testing of extracts, products, devices etc.

  • Microbial assay of antibiotics and vitamins

  • Specific pathogen detection in products

  • Water analysis

  • In vitro toxicity/safety studies

  • Analysis of products for Gliadin, afflotoxins, mycotoxins etc

  • Qualitative and Quantitative analysis of marker compounds in herbal extracts

Medicinal Chemistry

Medicinal Chemistry

NISHKA Labs offer all the facilities for the synthesis of wide range of compounds.

Our capabilities:

 

  • Key Building blocks , Scaffolds , Intermediates required to make several novel analogues to be screened in in-vitro studies

  • Novel Analogues from a Lead molecule to optimize its pharmacological activity

  • Focused libraries of 100- 200 compounds per scaffold to optimize the pK properties of a Lead molecule

  • Reference Standards useful in in-vitro and in-vivo biological screens – >99% purity

  • Custom synthesis of a Lead molecule in 100g scale to carry out pre clinical Toxicology studies

 

Our synthesis experience covers a broad range of compound classes including Carbocycles, Heterocycles, Carbohydrates, Amino acids, Chiral synthesis, Aromatic compounds, Steroid compounds & Small Peptides.

Biotechnology

Biotechnology

Biotechnology is one of the most revolutionary and beneficial scientific advances of the last quarter century. Biotechnology combines disciplines like genetics, molecular biology, biochemistry, embryology and cell biology, which are in turn linked to practical disciplines like chemical engineering, information technology, and robotics. An individual aspiring for career in Biotechnology should have a scientific aptitude and a keen interest in the biological sciences. Some other aspects like problem solving skills, information technology skill, analyzing and interpreting skills are also essential for a successful career in this field.

 

Plant Biotechnology:

 

  • Micropropagation of plants

  • Improvement of secondary metabolite levels

  • Development of Disease resistance varieties

  • Development of natural dyes through suspension cultures

  • Development of endangered plants through germplasm conservation

 

Cell Biology:

 

  • Cell proliferation, Cytostatic and Cytotoxicity studies

  • Hepatoprotective screening

  • Anticancer studies

  • Antidiabetic studies

  • Antiinflammatory studies

  • Phototoxicity test

  • Screening for biological markers (TNF-α, PGE, COX-2 etc.)

  • Immuno assays

  • High throughput Screening assays

 

Biochemistry:

 

  • Protein purification

  • Protein characterisation

  • Enzyme assays

  • Enzyme kinetics

  • Blood, urine analysis

  • Analysis of inorganic compounds (Minerals) by spectrophotometry/Atomic absorption spectroscopy

  • Proximate analysis of carbohydrate, proteins, lipids and nucleic acids.

  • Isolation and characterization of various lipid molecules

  • Vitamin analysis

Technical Consulting

Technical Consulting

We are one of the leading service providers engaged in offering Technical Consulting services to our valued clients. In order to meet the precise demands of clients, we offer customized Technical Consultation. Our consultants are expert and assist our clients in clearing the entire basic concepts and techniques. Apart from this, we also undertake various research works, projects and training.

 

We also under take consulting for client defined projects & offer the following services.

 

  • Preclinical Strategic Development

  • Structural Interpretation

  • Project Designing & Management

  • Product Development

  • Scientific paper writing and communicating

  • Industrial Training / Visits are arranged

  • Laboratory Designing

 

Instrumental Handling & Training

Instrumental Handling & Training

Keeping in mind the diversified specifications of industry we also conduct Instrumental Handling & Training for Research Scholars & Students. For these training we also offer certifications. We schedule these Trainings in such a way to meet the demanding needs and requirements of Industry. We conduct various lectures by experienced faculties from reputed universities and MNCs across India, to enable students inherit the concepts & procedures visually and practically.

 

Courses cover

 

  • Method Development by HPLC, UV/UVIS etc.,

  • Troubleshooting systems

  • System care and maintenance

  • Theory of separation mechanisms

  • Basic separation principles and

  • Advanced method development

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