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Shifix (Cefixime Trihydrate)
Cefixime (SHIFIX) is bactericidal and is stable to hyrolysis by many beta lactamase. It has a made of action and spectrum of activity similar to those of the third-generation cephalosporion Cefotoxime, but some Enterobacteriaeceae are less susceptible to Cefixime. H.influnzae, Morasella Catarrhalis and Neisseria gonorrhoea ae sensitive, including Penicillinase-producing strains. Of the gram-positive bacteria, streptococci are sensitive to Cefixime but most strains of Staphylococci, enterococci and Listeria spp are not. Enterobacter spp, Pseudomonas aeruginosa and Bacteriods spp are resistant to Cefixime. It is effective against anaerobic bacterial Pathogens. Cefixime is available as the trihydrate and doses expressed in terms of anhydrous Cefixime.
Shilof (ofloxacin 100/200 Mg Tab)
Ofloxacin is a Fluoroquinolone which inhibits the DNA gyrase. It has activity against C.trachomatis, M.leprae. M.tuberculosis and other Mycobacterium spp.Ofloxacin is bactericidal. It has a broader spectrum of activity and is more potent in vitro than the non-fluronated quinolone nalidixic acid although resistance to many species or strains previously sensitive is emerging. Its antimicrobial action and Ciprofloxacin is same. Ofloxacin is more active than Ciprofloxacin against Chyamydia trachomatis.
Shilof-oz (ofloxacin 200 Mg And Ornidazole 500 Mg Tab)
Ornidazole is active against protozoa and anaerobic bacteria and is used like metronidazole in the management of susceptible protozoal and anaerobic bacterial infections. Ornidazole longer T ½ (12-14 Hours) in comparison to that of metronidazole (6-8 Hours) is of particular advantage, for it favorably reduces the dosage frequency and duration of therapy in many of the relevant clinical infections.
SOVAXIN (Livofloxacin 250/500 Mg Tab)
Levofloxacin inhibits the relaxation of supercolled DNA by inhibition of DNA gyrase in susceptible organisms which maintains the super helical structure of DNA required by DNA replication, transcription, repair, recombination and transposition resulting to DNA strand breakase.Levofloxacin is a synthetic antibacterial agent of the fluoroquinolones & range is as for ciprofloxacin. Levofloxacin is generally considered to be about twice as active as Ofloxacin, the racemic substance. Levofloxacin has a broad spectrum of activity which includes gram-positive bacteria. Levofloxacin : an extended spectrum 4 quinolones agent. Superior coverage of key respiratory pathogens, including drug resistant S.pneumoniae and atypical pathogens.
Cefpodoxime proxetil is bactericidal and is stable to hydrolysis by many beta lactamase. It is a third generation cephalosporin with a broader spectrum of activity. It has greater activity than first or second generation cephalosporins against gram-negative bacteria. Cefpodoxime has greater activity against staphylococcus aureus. It is given orally as the proxetil easter, which is hydrolyzed on absorption to Cefpodoxime.
Azithromycin blocks transpeptidation by binding to 50s ribosomal subunit of susceptible organisms and disrupting RNA dependent protein synthesis at the chain elongation step.As far as antimicrobial spectrum is concerned, Azithromycin is a nitrogen containing macrolide (azalide) with action and uses similar to those of erythromycin. Azithromycin is less active than erothromycin against streptococci and staphylococci, but has greater activity than erythromycin in vitro against some gram-negetive organisms such as Haemophilus influenza and Moraxella Caterrhails, as well as having activity against some of the enterobacteriaceae such as E.coli and Salmonella and Shigella spp. Azithromycin is also more active against some opportunistic mycobacteria, including Mycobacterium avium (MAC) complex. It has activity against protozoa Toxoplama gondii and Plasmodium falciparum.
To,Shine Pharmaceuticals Limited