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Gastrocid Antacid
| Gastrocid is a novel and the first time antacid to be launched in Nigeria with alginic acid and magaldrate, this is the second revolutionary antacid formula to be launched in Nigeria, we Shridi Mirra Impex have used our expertise knowledge through experience to bring the unique pharmaceutical antacid formula to Nigeria, with the mission to bring quality health care management and the the best antacid to the entire west African region. This product is manufactured and exported by Shridi Mirra Impex at Sai Mirra Innopharm private Limited. We have our technical Partner and the distributed and marketed by Tomabel Pharma Nigeria Limited. |
 
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Gastrocid Antacid We manufacture Gastrocid antacid suspension which is a pharmaceutical antacid and anti flatulent antacid suspension.
Composition
Each 15 ml contains:
Alginic Acid BP 200 mg
Magaldrate BP 540 mg
Simethicone BP 125 mg
Description
Antacids are inorganic salts that dissolve in acid gastric secretions releasing anions that partially neutralize gastric hydrochloric acid.
Antacid react chemically to neutralize or buffer existing quantities of stomach acid but have no direct effect on its output. This action results in increased pH value of stomach contents, thus providing relief of hyperacidity symptoms. Also, these medications reduce acid concentration within the lumen of the esophagus. This causes an increase in intra-esophageal pH and a decrease in pepsin activity.
Pharmacodynamics & Pharmacokinetics:
Antacids are commonly used self-prescribed medications. They consist of calcium carbonate and magnesium and aluminum salts in various compounds or combinations. The effect of antacids on the stomach is due to partial neutralisation of gastric hydrochloric acid and inhibition of the proteolytic enzyme, pepsin. Each cation salt has its own pharmacological characteristics that are important for determination of which product can be used for certain indications. Antacids have been used for duodenal and gastric ulcers, stress gastritis, gastro-oesophageal reflux disease, pancreatic insufficiency, non-ulcer dyspepsia, bile acid mediated diarrhoea, biliary reflux, constipation, osteoporosis, urinary alkalinisation and chronic renal failure as a dietary phosphate binder. The development of histamine H2-receptor antagonists and proton pump inhibitors has significantly reduced usage for duodenal and gastric ulcers and gastro-oesophageal reflux disease. However, antacids can still be useful for stress gastritis and non-ulcer dyspepsia. The recent release of proprietary H2 antagonists has likely further reduced antacid use for non-ulcer dyspepsia. Other indications are still valid but represent minor uses. Antacid drug interactions are well noted, but can be avoided by rescheduling medication administration times. This can be inconvenient and discourage compliance with other medications. All antacids can produce drug interactions by changing gastric pH, thus altering drug dissolution of dosage forms, reduction of gastric acid hydrolysis of drugs, or alter drug elimination by changing urinary pH. Most antacids, except sodium bicarbonate, may decrease drug absorption by adsorption or chelation of other drugs. Most adverse effects from antacids are minor with periodic use of small amounts. However, when large doses are taken for long periods of time, significant adverse effects may occur especially patients with underlying diseases such as chronic renal failure. These adverse effects can be reduced by monitoring of electrolyte status and avoiding aluminum-containing antacids to bind dietary phosphate in chronic renal failure. Antacids, although effective for discussed indications of duodenal and gastric ulcer and gastro oesophageal reflux disease, have been replaced by newer, more effective agents that are more palatable to patients. Antacids are likely to continue to be used for non-ulcer dyspepsia, minor episodes of heartburn (gastro-oesophageal reflux disease) and other clear indications. Although their wide-spread use may decline, these drugs will still be used, and clinicians should be aware of their potential drug interactions and adverse effects.
Magaldrate/Simethicone Suspension is an antacid and antiflatulent combination. The antacid works by neutralizing stomach acid and increasing the pH of the stomach. The antiflatulent works by breaking up gas bubbles, which makes gas easier to eliminate |
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