Carbamazepine (
CBZ) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including attention-deficit hyperactivity disorder (ADHD),schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, neuromyotonia, and post-traumatic stress disorder.
Carbamazepine (
CBZ) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including attention-defic it hyperactivity disorder (ADHD),schizophrenia, phantom limb syndrome, paroxysmal extreme pain disorder, neuromyotonia, and post-traumatic stress disorder
| Systematic (IUPAC) name |
|
| 5H-dibenzo[b,f]azepine-5-carboxamide |
| Identifiers |
|
| CAS number | 298-46-4 85756-57-6 (dihydrate) |
| ATC code | N03AF01 |
| PubChem | CID 2554 |
| DrugBank | DB00564 |
| ChemSpider | 2457 |
| UNII | 33CM23913M |
| ChEMBL | CHEMBL108 |
| Chemical data |
|
| Formula | C15H12N2O |
| Mol. mass | 236.269 g/mol |
| SMILES | eMolecules & PubChem |
| InChI[show] |
| Pharmacokinetic data |
|
| Bioavailability | 80.00% |
| Protein binding | 76.00% |
| Metabolism | Hepatic—by CYP3A4, to activeepoxide form (carbamazepine-10,11 epoxide) |
| Half-life | 25–65 hours |
| Excretion | 2–3% excreted unchanged in urine |
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