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100 products available
- Lorcaserin HCl
- Metadoxin Active Pharmaceutical Ingredient
- Apremilast Form B
- HYDROXYPROGESTERONE CAPROATE IP/USP
- ESTRADIOL BENZOATE USP/BP
- Lafutidine
- Levodopa
- Dutasteride
- Cyclosporine
- Fulvestrant
- Lamotrigine
- Itraconazole
- Enzalutamide
- Econazole Nitrate
- Drotaverine
- Formoterol Fumarate
- Clomifene Citrate
- Dobutamine Hydrochloride
- Ethacrynate Sodium
- Emtricitabine
- Dexlansoprazole
- Docetaxel
- Crizotinib
- Dopamine
- Dimetindene Maleate
- Dapagliflozin
- Enalapril Maleate
- Eperisone Hydrochloride
- Efinaconazole
- Dolutegravir Sodium
- Citalopram
- Eltrombopag Olamine
- Dacarbazine
- Cyclophosphamide
- Cytarabine
- Brimonidine Tartrate
- Cisatracurium Besylate
- Cevimeline Hydrochloride
- Busulphan
- Cefotaxime Sodium
Active Pharmaceutical Ingredients - Api
Our range of products include Lorcaserin HCl, Metadoxin Active Pharmaceutical Ingredient, Apremilast Form B, HYDROXYPROGESTERONE CAPROATE IP/USP, ESTRADIOL BENZOATE USP/BP and Lafutidine.
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Lorcaserin hydrochloride is a selective serotonin 2C (5-HT2C) receptor agonist used as an active pharmaceutical ingredient (API) in weight management medications. It functions by activating receptors in the brain's hypothalamus, specifically those regulating appetite and satiety, leading to reduced food intake and promoted feelings of fullness. The hydrochloride salt form enhances the stability and bioavailability of the lorcaserin molecule. As a crystalline powder, it must be manufactured to strict pharmacopoeial standards (e.g., USP-NF) for identity, purity, strength, and impurity profiles to ensure safety and efficacy in the final pharmaceutical formulation.
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Metadoxin is an intravenous pharmaceutical formulation combining pyrrolidone derivatives (notably pyrrolidone carboxylate) with select B vitamins. It functions as a hepatic detoxifying agent and cognitive enhancer, primarily indicated for acute alcohol intoxication and withdrawal symptom management. The formulation aims to accelerate ethanol and acetaldehyde metabolism, replenish hepatic glutathione stores, and mitigate oxidative stress. By supporting liver function and neurotransmitter activity, it promotes sobriety, reduces hangover effects, and may improve mental clarity. It is used clinically in some regions as an adjunct treatment for alcohol-related metabolic disturbances and toxic encephalopathies. Its mechanism involves enhancing cellular energy metabolism and facilitating the elimination of neurotoxic substances.
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Apremilast Form B is a specific crystalline polymorph of the active pharmaceutical ingredient (API) used in the commercial drug Otezla�. It is characterized by a distinct X-ray powder diffraction (XRPD) pattern, with key peaks at approximately 6.5�, 17.5�, and 21.5� 2?. This thermodynamically stable form is preferentially manufactured for its optimal balance of physicochemical properties, including solubility, stability, and bioavailability. Its consistent solid-state structure ensures reliable drug product performance, batch-to-batch reproducibility, and long-term shelf life, making it the designated form for regulatory approval and global pharmaceutical production.
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HYDROXYPROGESTERONE CAPROATE IP/USP
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High quality-injectable API used in hormonal formulations.
Manufactured under GMP conditions with excellent purity profile.
Available in IP/BP/USP grades suitable for regulated and semi-regulated markets.
Widely used in progesterone-based formulations.
COA and supporting docs available.
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ESTRADIOL BENZOATE USP/BP
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Short acting-estrogen ester API.
Used in hormone and veterinary formulations.
Complies with USP/BP standards.
High purity crystalline form.
Batch-wise COA provided.
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Lafutidine is a second-generation histamine H?-receptor antagonist (H?RA) used primarily in the treatment of gastric and duodenal ulcers, gastritis, and gastroesophageal reflux disease (GERD). As an Active Pharmaceutical Ingredient (API), its mechanism involves potent inhibition of gastric acid secretion by competitively blocking histamine at parietal cell H? receptors. A key differentiating feature of lafutidine is its additional mucosal protective activity, attributed to its capsaicin-sensitive afferent neuron-stimulating properties, which enhance gastric mucosal blood flow and mucus secretion. This dual action�both antisecretory and cytoprotective�offers a therapeutic advantage over earlier H?RAs. The API is typically formulated into oral dosage forms, such as tablets or capsules, requiring strict control over purity, particle size, and stability to ensure consistent efficacy and safety in the final drug product.
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Levodopa (L-DOPA) is the direct metabolic precursor to the neurotransmitter dopamine. As a small-molecule API, it is the most effective and cornerstone pharmacological treatment for Parkinson's disease, a disorder characterized by dopamine deficiency in the brain. Its key advantage is the ability to cross the blood-brain barrier, unlike dopamine itself. Once centrally converted to dopamine, it ameliorates motor symptoms like bradykinesia, rigidity, and tremor. It is almost always administered with a peripheral decarboxylase inhibitor (e.g., carbidopa) to prevent its premature conversion in the periphery, thereby increasing central bioavailability and reducing peripheral side effects like nausea and cardiovascular effects.
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Dutasteride API (Active Pharmaceutical Ingredient) is a synthetic 4-azasteroid compound that acts as a potent, competitive, and selective dual inhibitor of both Type I and Type II 5?-reductase isoenzymes. This enzymatic inhibition prevents the conversion of testosterone to dihydrotestosterone (DHT), a key androgen implicated in androgenetic alopecia and benign prostatic hyperplasia (BPH). By significantly and durably suppressing serum DHT levels, dutasteride reduces prostate volume and improves urinary flow in BPH, and promotes hair regrowth in male pattern hair loss. It is formulated into soft gelatin capsules for oral administration, with its low aqueous solubility necessitating a dissolved lipid-filled presentation for adequate bioavailability.
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Cyclosporine is a potent immunosuppressive cyclic polypeptide composed of 11 amino acids, originally isolated from the fungus�Tolypocladium inflatum. As an active pharmaceutical ingredient (API), its primary mechanism of action involves forming a complex with cyclophilin, which then inhibits calcineurin phosphatase. This blockade prevents the dephosphorylation and nuclear translocation of NFAT (Nuclear Factor of Activated T-cells), thereby suppressing T-lymphocyte activation and proliferation. The API is highly lipophilic and insoluble in water, presenting significant formulation challenges. It is critical in preventing organ transplant rejection and treating autoimmune conditions like severe psoriasis and atopic dermatitis. Due to its narrow therapeutic index and potential for nephrotoxicity and hypertension, therapeutic drug monitoring is essential during treatment.
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Fulvestrant is an active pharmaceutical ingredient (API) used as an estrogen receptor antagonist. It is a selective estrogen receptor degrader (SERD), indicated for the treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women. Unlike other hormone therapies, it works by competitively binding to, blocking, and increasing the degradation of estrogen receptors, thereby inhibiting tumor growth. Administered via intramuscular injection due to poor oral bioavailability, its structure is based on a steroidal backbone. Manufactured under strict cGMP conditions, the Fulvestrant API is a high-potency compound requiring specialized handling to ensure purity, stability, and efficacy in the final formulated product.
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Lamotrigine is an anticonvulsant and mood-stabilizing active pharmaceutical ingredient (API). Chemically, it is a phenyltriazine derivative. Primarily used in the treatment of epilepsy (for partial and tonic-clonic seizures) and bipolar I disorder (for maintenance therapy), it functions by inhibiting voltage-sensitive sodium channels. This action stabilizes neuronal membranes and modulates the presynaptic release of excitatory neurotransmitters, particularly glutamate. As an API, lamotrigine is formulated into various dosage forms, most commonly oral tablets and orally disintegrating tablets. Its synthesis involves a multi-step organic process, and stringent pharmacopeial standards ensure its identity, purity, potency, and stability for safe pharmaceutical manufacturing.
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Itraconazole is a broad-spectrum triazole antifungal API used orally and intravenously. It acts by inhibiting fungal cytochrome P450, disrupting ergosterol synthesis in the cell membrane. It is effective against a wide range of fungi, including Aspergillus, Candida, and dermatophytes. The API is highly lipophilic and requires an acidic environment for optimal absorption. It is extensively metabolized in the liver, producing an active metabolite, hydroxyitraconazole. Key clinical applications include systemic mycoses, onychomycosis, and candidiasis. As a BCS Class II drug, its formulation often focuses on enhancing solubility and bioavailability, for example, through solid dispersions or cyclodextrin complexes.
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Enzalutamide API is the active pharmaceutical ingredient in the prostate cancer medication Xtandi�. It is a non-steroidal, second-generation antiandrogen that potently and selectively inhibits the androgen receptor signaling pathway. By competitively binding to the receptor and blocking its nuclear translocation and DNA binding, enzalutamide impedes tumor growth and progression. It is specifically indicated for castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. As a high-potency small molecule, the API is formulated into oral tablets. Its manufacturing requires strict control over polymorphism and purity to ensure therapeutic efficacy and safety, meeting stringent global pharmacopoeial standards.
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Econazole Nitrate is a broad-spectrum imidazole antifungal active pharmaceutical ingredient (API). It works by inhibiting ergosterol synthesis, disrupting fungal cell membrane integrity. Primarily used topically, it treats cutaneous infections like athlete's foot, ringworm, and pityriasis versicolor caused by dermatophytes, yeasts, and molds. The nitrate salt form enhances stability and solubility. As a classic azole antifungal, it exhibits both fungistatic and fungicidal activity. Its mechanism and efficacy have made it a standard in over-the-counter and prescription antifungal creams, powders, and solutions for decades, valued for its reliability in managing superficial mycoses.
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Drotaverine is a synthetic isoquinoline derivative acting as a potent, selective inhibitor of phosphodiesterase type 4 (PDE4). This mechanism results in direct smooth muscle antispasmodic action, primarily on vascular, gastrointestinal, biliary, and genitourinary tracts. Unlike anticholinergics, it does not affect autonomic nervous system function, minimizing side effects like dry mouth or blurred vision. It is indicated for conditions involving smooth muscle spasm, such as renal or biliary colic, dysmenorrhea, and irritable bowel syndrome. Its high tissue selectivity and favorable safety profile make it a widely used spasmolytic agent in clinical practice, often preferred for its efficacy and tolerability.
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Formoterol Fumarate is a long-acting beta?-adrenergic receptor agonist (LABA) API. As a bronchodilator, it acts by relaxing airway smooth muscle, providing rapid and sustained relief from bronchoconstriction. It is primarily used in the management of asthma and chronic obstructive pulmonary disease (COPD). The fumarate salt form enhances the stability and solubility of the free base. In pharmaceutical formulations, it is a critical component of dry powder inhalers (DPIs) and pressurized metered-dose inhalers (pMDIs), often combined with inhaled corticosteroids for synergistic anti-inflammatory effects. Its characteristic prolonged duration of action (up to 12 hours) makes it a cornerstone of maintenance therapy for obstructive airway diseases.
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Clomifene Citrate is a non-steroidal, orally active selective estrogen receptor modulator (SERM) used as an active pharmaceutical ingredient (API). It acts as a mixed agonist-antagonist at estrogen receptors in the hypothalamus, blocking negative feedback and increasing gonadotropin-releasing hormone (GnRH) secretion. This stimulates the pituitary gland to release follicle-stimulating hormone (FSH) and luteinizing hormone (LH), thereby inducing ovulation in anovulatory women. It is a racemic mixture of enclomiphene and zuclomiphene isomers. As an API, it is formulated into tablets for the treatment of female infertility, particularly in patients with polycystic ovary syndrome (PCOS). Its quality must comply with strict pharmacopoeial standards (e.g., USP, Ph. Eur.).
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Dobutamine Hydrochloride API is a synthetic catecholamine and direct-acting inotropic agent, primarily used in the treatment of acute heart failure and cardiogenic shock. As a predominantly ?1-adrenergic receptor agonist, it increases myocardial contractility and cardiac output with minimal effect on heart rate or peripheral vascular resistance. This white to off-white crystalline powder is supplied as a sterile, non-pyrogenic lyophilized powder for solution. It is manufactured under strict cGMP guidelines, ensuring high purity and consistent quality for use in critical care injectable formulations. Its synthesis involves multi-step organic reactions, with rigorous control over impurities and related substances.
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Ethacrynate Sodium is the sodium salt of ethacrynic acid, a potent loop diuretic active pharmaceutical ingredient (API). It acts by inhibiting the Na?/K?/2Cl? cotransporter in the thick ascending limb of the loop of Henle, promoting the excretion of sodium, chloride, and water. Primarily used in the management of edema associated with congestive heart failure, hepatic cirrhosis, and renal disease, it is particularly valuable when a rapid or pronounced diuretic effect is required. The sodium salt form offers enhanced water solubility compared to the acid, facilitating its formulation for intravenous administration, especially in hospital settings for urgent clinical situations.
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Emtricitabine is a synthetic nucleoside reverse transcriptase inhibitor (NRTI) used as a core antiretroviral agent. As an Active Pharmaceutical Ingredient (API), it is a white to off-white crystalline powder with high purity, typically exceeding 99%. Chemically, it is analogous to cytidine. Its primary mechanism is the inhibition of HIV-1 and HIV-2 replication by competing with natural cytidine, terminating the viral DNA chain. The API exhibits high solubility in water and methanol. It is manufactured under strict cGMP conditions, with critical quality attributes including assay, related substances, residual solvents, and particle size distribution. It is the key component in fixed-dose combination therapies for HIV treatment and prevention (PrEP).
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Dexlansoprazole is a proton pump inhibitor (PPI) used to suppress gastric acid secretion. As the active (R)-enantiomer of lansoprazole, it offers more targeted pharmacologic activity. Its key innovation is a dual delayed-release formulation, which provides two distinct pH-dependent releases from a single capsule. This extends the plasma concentration-time profile, allowing for prolonged acid suppression and consistent 24-hour pH control with once-daily dosing. Clinically, it is indicated for healing and maintenance in erosive esophagitis and for treating symptomatic non-erosive gastroesophageal reflux disease (GERD). The API is typically formulated into delayed-release capsules for oral administration.
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Docetaxel is a potent semisynthetic taxane derivative anticancer API (Active Pharmaceutical Ingredient). It functions as a microtubule stabilizer, binding to tubulin to inhibit depolymerization, thereby arresting cell division in the mitotic (M) phase and inducing apoptosis in rapidly proliferating cancer cells. Primarily used in the treatment of breast, non-small cell lung, prostate, gastric, and head/neck cancers, it is typically administered via intravenous infusion. As a high-potency cytotoxic agent, docetaxel requires stringent handling and manufacturing controls. Its poor aqueous solubility necessitates formulation with surfactants (e.g., polysorbate 80), which can contribute to significant side effects, including myelosuppression and fluid retention.
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Crizotinib is a small-molecule, orally-administered tyrosine kinase inhibitor used as an active pharmaceutical ingredient (API) in targeted cancer therapy. It primarily inhibits anaplastic lymphoma kinase (ALK), ROS1, and MET kinases. By blocking these signaling pathways, it disrupts the proliferation and survival of cancer cells harboring specific genetic alterations. The API is most notably formulated into capsules for treating ALK-positive or ROS1-positive advanced non-small cell lung cancer (NSCLC). Its development marked a pivotal shift towards precision oncology, offering improved outcomes for patients with these driver mutations. As a critical API, its synthesis and quality control are tightly regulated to ensure purity, potency, and consistent therapeutic performance.
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Dopamine API is a lightweight RESTful interface designed for seamless integration of real-time data streaming and analytics into applications. It enables developers to capture, process, and visualize high-volume event data with minimal latency. Featuring simple authentication, flexible endpoints, and scalable WebSocket support, the API is ideal for IoT dashboards, financial tickers, live monitoring tools, and interactive platforms requiring instant data updates. Its efficient architecture ensures low overhead while maintaining robust performance, allowing teams to focus on building dynamic user experiences without backend complexity. Dopamine API delivers the instant data "rush" that modern applications demand.
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Dimetindene Maleate is a potent, first-generation alkylamine antihistamine API. It acts as a selective H1 receptor antagonist, effectively blocking the action of histamine to alleviate symptoms of allergic conditions such as rhinitis, conjunctivitis, and urticaria. The maleate salt enhances its stability and solubility. Characterized by rapid onset and strong antipruritic activity, it may exhibit some sedative effects due to CNS penetration. Its molecular structure allows for effective competitive inhibition at receptor sites. The API is typically formulated into oral tablets or topical preparations. It remains a key therapeutic agent for managing immediate hypersensitivity reactions, providing reliable symptomatic relief.
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Dapagliflozin is a potent, selective, and orally active sodium-glucose cotransporter 2 (SGLT2) inhibitor used as the active pharmaceutical ingredient (API) in antidiabetic medications. As a small molecule derived from the glucitol core of phlorizin, it works by blocking SGLT2 proteins in the proximal renal tubules, thereby reducing renal glucose reabsorption and increasing urinary glucose excretion. This insulin-independent mechanism lowers blood glucose levels in patients with type 2 diabetes. The API is typically supplied as a crystalline propanediol monohydrate (C??H??ClO?�C?H?O?�H?O). Its synthesis involves multiple chiral steps to achieve the desired d-glucitol configuration, ensuring high purity and stability for final formulation into tablets.
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Enalapril Maleate is the maleate salt of enalapril, an angiotensin-converting enzyme (ACE) inhibitor. As the active pharmaceutical ingredient (API), it is a prodrug that undergoes hepatic hydrolysis to form enalaprilat, the active metabolite. This compound competitively inhibits ACE, preventing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. The resulting vasodilation, reduced aldosterone secretion, and increased bradykinin levels effectively lower blood pressure. It is widely used in the formulation of tablets for the treatment of hypertension and heart failure. The API is typically a white to off-white crystalline powder, sparingly soluble in water, and must be manufactured to stringent pharmacopoeial standards for purity, potency, and stability.
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Eperisone Hydrochloride is a centrally acting muscle relaxant active pharmaceutical ingredient (API). It functions primarily as a myotonolytic agent by depressing the gamma-efferent system's activity and exerting a vasodilatory effect. Its therapeutic action relieves muscle rigidity, spasticity, and associated pain by reducing muscle tone without significantly affecting voluntary motor function. Clinically, it is widely used in the management of conditions like muscle contractures, low back pain, cervical spondylosis, and other musculoskeletal disorders. The API is typically formulated into oral tablets or capsules. As a bespoke compound, its quality is strictly controlled according to pharmacopeial standards to ensure purity, potency, and safety for pharmaceutical manufacturing.
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Efinaconazole is a modern triazole antifungal agent, specifically formulated as a topical solution for the treatment of onychomycosis (fungal nail infections). As an active pharmaceutical ingredient (API), it inhibits the fungal lanosterol 14?-demethylase, a key cytochrome P450 enzyme, thereby disrupting ergosterol synthesis in the fungal cell membrane. Its distinct molecular structure provides broad-spectrum activity against dermatophytes, yeasts, and molds. A key advantage is its low affinity for keratin, enhancing its ability to penetrate the dense nail plate and reach the infection site. This targeted mechanism of action, combined with its efficacy and favorable safety profile, makes it a significant advancement in topical antifungal therapy.
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Dolutegravir Sodium is the active pharmaceutical ingredient (API) of the antiretroviral drug Tivicay� and a key component in fixed-dose combinations like Juluca� and Dovato�. As an integrase strand transfer inhibitor (INSTI), it works by blocking the HIV integrase enzyme, preventing the viral DNA from integrating into the host genome. This sodium salt form of dolutegravir enhances solubility and stability for formulation. It is a cornerstone of modern HIV-1 treatment regimens due to its high efficacy, high genetic barrier to resistance, and generally favorable safety profile. The API is manufactured under strict cGMP guidelines to ensure purity, potency, and consistency for global therapeutic use.
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Citalopram is a selective serotonin reuptake inhibitor (SSRI) used as an antidepressant. As an active pharmaceutical ingredient (API), it is a racemic mixture, with the (S)-enantiomer (escitalopram) primarily responsible for its therapeutic effect. It works by increasing serotonin levels in the brain by blocking its reuptake into presynaptic neurons. The citalopram API is a white to off-white crystalline powder, sparingly soluble in water. It is formulated into tablets, oral solutions, and drops. Key quality attributes include purity, particle size, and polymorphic form, which are tightly controlled during synthesis, typically starting from phthalide derivatives.
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Eltrombopag olamine is the bis(monoethanolamine) salt of eltrombopag, a small molecule, non-peptide thrombopoietin receptor agonist. It acts as an orally bioavailable agonist at the transmembrane domain of the human TPO receptor (c-Mpl), selectively stimulating megakaryocyte proliferation and differentiation in the bone marrow. This leads to increased platelet production. Its primary clinical application is in the treatment of thrombocytopenia associated with chronic immune (idiopathic) thrombocytopenia (ITP), chronic hepatitis C, and severe aplastic anemia. As the active pharmaceutical ingredient (API), it is formulated into tablets for oral administration, representing a critical therapy for conditions characterized by dangerously low platelet counts.
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Dacarbazine (DTIC) is a synthetic cytotoxic antineoplastic alkylating agent, used primarily in the treatment of metastatic malignant melanoma and Hodgkin's lymphoma. As a prodrug, it requires hepatic metabolic activation to exert its therapeutic effect. Its mechanism of action involves alkylation of DNA, leading to cross-linking and inhibition of DNA, RNA, and protein synthesis. It is also classified as a purine analog, interfering with nucleic acid metabolism. Supplied typically as a sterile, lyophilized powder for intravenous injection, it is light-sensitive and requires storage under refrigeration. Its use is associated with significant side effects, including severe nausea, vomiting, and myelosuppression.
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Cyclophosphamide is a nitrogen mustard alkylating agent used as an antineoplastic and immunosuppressive API. As a prodrug, it requires hepatic activation to form phosphoramide mustard and acrolein, which crosslink DNA strands, disrupting replication in rapidly dividing cells. Primarily indicated for various cancers (lymphomas, leukemias, solid tumors) and, at lower doses, severe autoimmune conditions. Key handling precautions are required due to its toxicity, including carcinogenicity and reproductive harm. It is typically administered orally or intravenously. Common severe adverse effects include myelosuppression, hemorrhagic cystitis (mitigated with mesna), and nausea. It remains a cornerstone chemotherapeutic agent in oncology and transplant medicine.
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Cytarabine is a potent antineoplastic and antiviral API, classified as a pyrimidine nucleoside analog. Its primary mechanism of action involves incorporation into DNA during the S-phase of cell division, inhibiting DNA polymerase and leading to chain termination. This results in the death of rapidly dividing cells. It is a cornerstone chemotherapeutic agent, essential for treating acute myeloid leukemia (AML) and other hematologic malignancies. As a white to off-white crystalline powder, it is typically administered via injection or infusion. Due to its cell-cycle specificity and myelosuppressive effects, precise dosing and patient monitoring are critical. It is also used intrathecally for meningeal leukemia.
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Brimonidine tartrate is a selective alpha-2 adrenergic receptor agonist used as an active pharmaceutical ingredient (API). Primarily formulated into ophthalmic solutions, it lowers intraocular pressure by reducing aqueous humor production and increasing uveoscleral outflow, making it a first-line treatment for open-angle glaucoma and ocular hypertension. It also possesses vasoconstrictive and anti-inflammatory properties, which are utilized in topical formulations for rosacea. As an API, it is supplied as a white to off-white crystalline powder, soluble in water. Its mechanism provides a neuroprotective benefit beyond IOP reduction, contributing to its therapeutic profile. Quality standards comply with major pharmacopoeias (USP, Ph. Eur.).
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Cisatracurium Besylate is a non-depolarizing neuromuscular blocking agent belonging to the benzylisoquinolinium class. It is the besylate salt of the active pharmaceutical ingredient, cisatracurium. The API acts as a competitive antagonist at nicotinic cholinergic receptors on the motor end-plate, inducing skeletal muscle paralysis. Its key advantages are a predictable duration of action and metabolism independent of organ function. Primarily degraded via Hofmann elimination (a pH- and temperature-dependent non-enzymatic process) and ester hydrolysis, it offers a favorable cardiovascular safety profile with minimal histamine release. The API is typically a white to off-white powder, synthesized as a single stereoisomer of atracurium, and is formulated as a sterile injectable solution for use in surgical anesthesia and intensive care.
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Cevimeline hydrochloride is a cholinergic agonist API primarily used to treat symptoms of dry mouth in patients with Sj�gren's syndrome. It acts as a muscarinic receptor agonist, stimulating exocrine gland secretions, notably from salivary and sweat glands. Chemically, it is a stable, white to off-white crystalline powder, soluble in water. As an active pharmaceutical ingredient, it is formulated into oral capsules. Its mechanism involves binding to M3 receptors, enhancing fluid output. Strict quality controls ensure high purity and potency for consistent therapeutic effect, improving oral health and patient comfort in xerostomia management.
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Busulphan (busulfan) is a bifunctional alkylating antineoplastic agent. Chemically, it is 1,4-butanediol dimethanesulfonate. It acts primarily by forming DNA interstrand crosslinks, disrupting DNA replication and transcription, which leads to cell death, particularly in rapidly dividing cells like myeloid progenitors. Its primary therapeutic use is as a conditioning agent prior to hematopoietic stem cell transplantation (HSCT), where it provides myeloablation to create space for donor cells. It is indicated for chronic myeloid leukemia and, in high-dose regimens, for various leukemias and genetic diseases prior to transplant. The API is typically a white crystalline powder, with strict pharmacopeial controls on purity, related substances, and residual solvents due to its narrow therapeutic index and potency.
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Cefotaxime Sodium is a broad-spectrum, third-generation cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria. It is the sodium salt form of cefotaxime, which improves water solubility for parenteral administration. The API (Active Pharmaceutical Ingredient) works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Its key advantage is high stability against many beta-lactamase enzymes. It is effective against pathogens like�Escherichia coli,�Klebsiella pneumoniae,�Neisseria gonorrhoeae, and�Streptococcus pneumoniae, but less active against�Pseudomonas aeruginosa. As the essential bulk drug substance, it is formulated into sterile injectable powders and solutions used to treat serious infections such as septicemia, meningitis, and complicated intra-abdominal infections.
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