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100 products available
- Gabapentin
- Quinidine
- Telmisartan
- Acefylline Piperazine
- Albendazole
- Ensulizole
- Irinotecan
- Clarithromycin
- Hydroquinone
- Levoketoconazole
- Ivacaftor
- Temsirolimus
- Bosentan
- Bimatoprost
- Brexpiprazole
- Valethamate Bromide
- Betaine Anhydrous
- Amlodipine
- Voclosporin
- Sucroferric Oxyhydroxide
- Aprepitant
- Sodium Picosulfate
- Warfarin Sodium
- Acebutolol Hydrochloride
- Sirolimus
- Terbinafine
- Vigabatrin
- Sorafenib Tosylate
- Promethazine
- Roxithromycin
- Pretomanid
- Valganciclovir
- Procaine
- Selexipag
- Selegiline Hydrochloride
- Sulfadoxine
- Tavaborole
- Terconazole
- Romidepsin
- Pimecrolimus
Api
Manufacturer of a wide range of products which include Gabapentin, Quinidine, Telmisartan, Acefylline Piperazine, Albendazole and Ensulizole.
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Gabapentin API (Active Pharmaceutical Ingredient) is a white to off-white crystalline powder, freely soluble in water. Chemically, it is a gamma-aminobutyric acid (GABA) analogue, though its exact mechanism of action is not fully understood. It is primarily used as an antiepileptic and for neuropathic pain management. The API is manufactured under strict GMP conditions, with a typical assay purity of ?99.0%. Key quality attributes include control of related substances (impurities), residual solvents, and particle size distribution. It is hygroscopic and requires protection from moisture. Gabapentin API is the essential bulk component formulated into capsules, tablets, and oral solutions.
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Quinidine is a pharmaceutical active ingredient (API) belonging to the class Ia antiarrhythmic agents. Derived from the bark of�Cinchona�trees, it is the dextrorotatory stereoisomer of quinine. Its primary therapeutic action is to block myocardial sodium and potassium channels, prolonging the cardiac action potential and effective refractory period. This makes it effective for suppressing certain supraventricular and ventricular arrhythmias, including atrial fibrillation and flutter. As an API, it is formulated into sulfate or gluconate salts for oral or intravenous administration. Its use requires careful monitoring due to a narrow therapeutic index and potential for serious adverse effects, including cinchonism, hypotension, and proarrhythmia.
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Telmisartan is an angiotensin II receptor blocker (ARB) API used primarily as an antihypertensive. It works by selectively blocking the binding of angiotensin II to the AT1 receptor, inhibiting vasoconstriction and aldosterone secretion. A key differentiator is its exceptionally long plasma half-life (~24 hours), enabling sustained 24-hour blood pressure control with once-daily dosing. It also exhibits unique partial agonistic activity on peroxisome proliferator-activated receptor-gamma (PPAR-?), offering potential metabolic benefits. Manufactured via a multi-step organic synthesis, its final form is a white to slightly yellowish crystalline powder, practically insoluble in water. It is the active pharmaceutical ingredient in medications for hypertension and cardiovascular risk reduction.
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Acefylline piperazine API is a xanthine derivative bronchodilator used as an active pharmaceutical ingredient (API) in the treatment of respiratory conditions. It functions primarily as a phosphodiesterase inhibitor and adenosine receptor antagonist, promoting the relaxation of bronchial smooth muscle. This action facilitates airway dilation and improves respiratory function, making it effective for managing symptoms of asthma and chronic obstructive pulmonary disease (COPD). The piperazine salt form enhances the solubility and bioavailability of the acefylline base. As an API, it is formulated into oral solid dosage forms, such as tablets, for therapeutic use.
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Albendazole API is a broad-spectrum anthelmintic Active Pharmaceutical Ingredient (API) belonging to the benzimidazole class. It is a key medicine for treating parasitic worm infections, including those caused by tapeworms, roundworms, and flukes. Its primary mode of action is by selectively inhibiting tubulin polymerization within the parasite, disrupting cellular transport and energy metabolism, leading to its death. As a prodrug, albendazole is metabolized in the liver to its active sulfoxide form, which achieves systemic distribution. It is the cornerstone API for medications targeting neurocysticercosis and hydatid disease. Manufactured to high pharmacopoeial standards (e.g., USP, Ph. Eur.), its quality is critical for global public health programs against neglected tropical diseases.
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Ensulizole (benzophenone-4) is a water-soluble organic ultraviolet (UV) filter, primarily absorbing within the UVB spectrum (290�320 nm). It is a white to off-white, crystalline powder, freely soluble in water and alcohols. As a sulfonic acid derivative, it is inherently anionic and functions by dissipating absorbed UV energy as harmless heat. Its key advantage in sunscreens and cosmetic formulations is its resistance to wash-off from water or sweat, providing durable photoprotection. It is commonly used in combination with other UV filters to achieve broad-spectrum coverage and enhance SPF efficacy, particularly in light, non-greasy lotions, sprays, and daily wear cosmetics.
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Irinotecan hydrochloride is a topoisomerase I inhibitor used as an anticancer API, primarily in the treatment of metastatic colorectal cancer. It is a prodrug, metabolized in vivo to its active moiety, SN-38, which stabilizes the covalent topoisomerase I-DNA complex, preventing DNA relegation and causing lethal double-strand breaks during replication. This cytotoxic action leads to apoptosis in rapidly dividing cancer cells. It is administered via intravenous infusion. The API is a pale yellow to yellow crystalline powder, slightly soluble in water. Key challenges in its use include managing dose-limiting toxicities, notably severe diarrhea and myelosuppression. It is often used in combination regimens like FOLFIRI.
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Clarithromycin API is a macrolide antibiotic active substance used in the formulation of various pharmaceutical dosage forms, primarily tablets and suspensions. It acts by inhibiting bacterial protein synthesis, exhibiting efficacy against a broad spectrum of Gram-positive and some Gram-negative bacteria, including respiratory pathogens like�Haemophilus influenzae. Notably, it is a key therapeutic agent for treating common community-acquired infections such as bronchitis, pneumonia, and sinusitis. The API is a semi-synthetic derivative of erythromycin, with improved acid stability and bioavailability. Its quality is strictly controlled according to pharmacopoeial standards (e.g., USP, Ph. Eur.) to ensure identity, purity, potency, and safety in the final drug product.
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Hydroquinone (C?H?(OH)?) is a well-established pharmaceutical active ingredient primarily used as a topical depigmenting agent. It functions by selectively inhibiting the enzyme tyrosinase, which is crucial for the synthesis of melanin within skin melanocytes. This reversible suppression of pigment production makes it effective in treating hyperpigmentation disorders such as melasma, post-inflammatory hyperpigmentation, and solar lentigines. Typically formulated in creams or gels at concentrations of 2�4% (available by prescription, with higher strengths often regulated), its use requires medical supervision due to potential side effects like skin irritation, ochronosis (with prolonged use), and concerns about long-term safety.
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Levoketoconazole is the purified 2S,4R stereoisomer of ketoconazole, developed to provide a more targeted therapeutic profile. Unlike the racemic mixture, which contains both active and inactive forms, this enantiomer exhibits enhanced selectivity for steroidogenic enzymes, particularly 11?-hydroxylase. This results in potent inhibition of cortisol synthesis with reduced off-target effects on other hepatic enzymes, improving its safety profile. It is specifically indicated for the treatment of endogenous Cushing's syndrome, offering a more precise mechanism of action. The purification process eliminates the less active enantiomer, allowing for lower dosages and potentially mitigating the hepatotoxicity and drug-drug interactions historically associated with classic ketoconazole.
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Ivacaftor is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, developed by Vertex Pharmaceuticals. As a small-molecule drug, it specifically targets the defective CFTR protein in patients with certain gating mutations (e.g., G551D). By binding to the CFTR protein at the cell surface, ivacaftor enhances its channel gating activity, facilitating increased chloride and bicarbonate ion transport. This corrects the underlying ion imbalance, improving hydration of airway surface liquid and mucociliary clearance. It represents the first therapy addressing the root cause of CF for a subset of patients, leading to significant improvements in lung function, weight gain, and quality of life. It is marketed under the brand name Kalydeco.
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Temsirolimus API is the active pharmaceutical ingredient of the antineoplastic drug Torisel�. Chemically, it is a semi-synthetic derivative of sirolimus (rapamycin) formulated as a prodrug. It is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase, a critical regulator of cell growth, proliferation, and survival. By blocking mTOR signaling, it induces cell cycle arrest and inhibits angiogenesis. The API is a white to off-white powder that is insoluble in water. It is specifically indicated for the treatment of advanced renal cell carcinoma (RCC). As a potent cytostatic agent, its manufacture requires strict control over purity, polymorphism, and particle size distribution.
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Bosentan is a potent endothelin receptor antagonist used as an active pharmaceutical ingredient (API). It acts by selectively blocking endothelin-1 receptors (ETA and ETB), inhibiting the vasoconstrictive and proliferative effects of endothelin. This makes it a cornerstone therapy for pulmonary arterial hypertension (PAH), improving exercise capacity and hemodynamics. As a white to pale-yellow crystalline powder, it is practically insoluble in water. Bosentan is a BCS Class II drug, requiring careful formulation for bioavailability. Its synthesis is complex, involving multiple steps. Critical quality attributes include strict control of genotoxic impurities. As a key component in finished dosage forms, typically tablets, it requires stringent pharmacopeial compliance and cold-chain storage stability management.
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Bimatoprost is a synthetic prostaglandin analogue primarily utilized in ophthalmic solutions to reduce intraocular pressure, effectively managing conditions like glaucoma and ocular hypertension. It functions by enhancing uveoscleral outflow and increasing trabecular meshwork permeability. Additionally, bimatoprost promotes eyelash growth as a side effect, leading to its development for cosmetic use in treating hypotrichosis. The active pharmaceutical ingredient (API) is typically formulated as a sterile, isotonic solution for topical application. Its synthesis involves complex organic chemistry to ensure high purity and potency. As a critical therapeutic agent, bimatoprost API must comply with stringent pharmacopeial standards for identity, assay, impurities, and sterility.
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Brexpiprazole is an atypical antipsychotic active pharmaceutical ingredient (API) used primarily in the treatment of major depressive disorder (as an adjunct) and schizophrenia. It functions as a partial agonist at serotonin 5-HT1A and dopamine D2 receptors, and as an antagonist at serotonin 5-HT2A receptors. This unique receptor profile aims to stabilize neurotransmitter systems, improving symptoms with a potentially favorable tolerability profile regarding weight gain and sedation compared to some older antipsychotics. The API is synthesized into various dosage forms, most commonly oral tablets, under strict pharmaceutical manufacturing controls to ensure purity, potency, and consistency for therapeutic use.
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Valethamate bromide is an anticholinergic and antispasmodic active pharmaceutical ingredient (API) used primarily to treat abdominal cramps, irritable bowel syndrome, and renal colic. It acts as a competitive muscarinic acetylcholine receptor antagonist, inhibiting smooth muscle contractions in the gastrointestinal and genitourinary tracts. This provides rapid relief from spasmodic pain. The API is typically formulated into tablets or injectable solutions. Its use requires medical supervision due to potential side effects like dry mouth, blurred vision, and tachycardia. Valethamate bromide is known for its potent spasmolytic action with a relatively rapid onset, making it effective for acute symptomatic management.
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Betaine Anhydrous API is a highly purified, crystalline form of trimethylglycine, produced as an active pharmaceutical ingredient. It is a naturally occurring osmolyte and methyl donor, synthesized via chemical processes to meet stringent pharmacopeial standards (e.g., USP, Ph. Eur.). The white, hygroscopic powder is characterized by its high purity (typically >98.5%), low heavy metal content, and controlled residual solvents. Its primary therapeutic mechanism involves regulating cellular osmotic pressure and facilitating homocysteine remethylation to methionine. As a GMP-manufactured API, it is the key component in prescription medications used to treat homocystinuria and support liver and metabolic function.
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Amlodipine is a long-acting calcium channel blocker (CCB) used primarily as an antihypertensive and antianginal agent. As an active pharmaceutical ingredient (API), it is chemically described as a dihydropyridine derivative. It works by selectively inhibiting calcium ion influx into vascular smooth muscle and cardiac muscle, leading to peripheral arterial vasodilation and reduced systemic vascular resistance. This results in lowered blood pressure and decreased myocardial oxygen demand. The API is typically formulated as besylate, mesylate, or maleate salts to enhance stability and bioavailability. Amlodipine is characterized by its slow onset and prolonged duration of action, allowing for once-daily dosing. It is a cornerstone in managing hypertension and chronic stable angina.
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Voclosporin is a novel calcineurin inhibitor immunosuppressant, chemically modified from ciclosporin to enhance efficacy and predictability. As an API (Active Pharmaceutical Ingredient), it is a potent, orally administered agent primarily developed for the treatment of autoimmune diseases, notably lupus nephritis. Its key structural modification provides more consistent pharmacokinetics, including reduced metabolic variability and a predictable dose-response relationship. The API works by inhibiting calcineurin, thereby downregulating T-cell activation and the production of inflammatory cytokines. Manufactured under strict cGMP conditions, voclosporin API enables the formulation of capsules that offer a targeted mechanism of action with an improved therapeutic window compared to earlier calcineurin inhibitors.
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Sucroferric oxyhydroxide is a polynuclear iron(III)-oxyhydroxide complex stabilized with a carbohydrate polymer (sucrose). It serves as a non-calcium, non-resin phosphate binder used in the active pharmaceutical ingredient (API) form for the production of medications for chronic kidney disease patients. Its mechanism relies on the high affinity of its iron-based core to chelate dietary phosphate in the gastrointestinal tract, forming insoluble complexes that are excreted, thereby reducing serum phosphate levels. The API is characterized as a dark brown to black amorphous powder, insoluble in water. Its efficacy stems from its high phosphate-binding capacity per unit mass, which allows for lower pill burdens compared to some traditional binders.
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Aprepitant is an active pharmaceutical ingredient (API) that functions as a potent, selective antagonist of the human substance P/neurokinin 1 (NK1) receptor. It is the key therapeutic component in medications used for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). By blocking the binding of substance P in the brain, aprepitant inhibits the emetic pathway triggered by chemotherapeutic agents. It is typically administered orally in combination with other antiemetics. As a high-potency API, its synthesis involves complex multi-step organic chemistry, and it is formulated into capsules for clinical use, playing a critical role in supportive cancer care.
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Sodium Picosulfate is a potent contact stimulant laxative used primarily for bowel evacuation prior to diagnostic procedures or surgery. As a prodrug, it remains inactive until hydrolyzed by colonic sulfatase enzymes from gut microbiota into its active metabolite, BHPM. This compound directly stimulates the colonic mucosa, enhancing peristalsis and fluid secretion. Its local action within the colon minimizes systemic absorption and side effects. Available in oral solution and powder formulations, it is a key component of popular bowel-cleansing regimens, often combined with magnesium citrate. Sodium Picosulfate is valued for its predictable onset and effective clearance, though it requires adequate hydration and is contraindicated in certain conditions like ileus or severe inflammatory bowel disease.
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Warfarin Sodium is the sodium salt of warfarin, a coumarin derivative widely employed as an oral anticoagulant API. It acts as a vitamin K antagonist, inhibiting the synthesis of active clotting factors (II, VII, IX, X) in the liver. This mechanism effectively prevents and treats thromboembolic disorders like deep vein thrombosis, pulmonary embolism, and reduces stroke risk in atrial fibrillation. Its therapeutic effect is delayed, requiring 2-3 days for full anticoagulation. The API exhibits a narrow therapeutic index and significant individual variability in dose response, necessitating careful patient management and routine INR monitoring to balance efficacy against bleeding risk.
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Acebutolol Hydrochloride API is a cardio-selective beta-1 adrenergic receptor blocker with intrinsic sympathomimetic activity. Used as an active pharmaceutical ingredient (API), it is primarily indicated for the management of hypertension, angina pectoris, and certain cardiac arrhythmias. The compound works by selectively inhibiting beta-1 receptors in the heart, reducing heart rate, contractility, and blood pressure. Its mild partial agonist activity may offer advantages in reducing certain side effects like bradycardia. The hydrochloride salt form enhances the stability and solubility of the molecule for pharmaceutical formulation. As an API, it is manufactured under strict quality controls for incorporation into oral solid dosage forms, typically capsules.
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Sirolimus is a macrolide compound originally isolated from�Streptomyces hygroscopicus, functioning as a potent immunosuppressant and mTOR (mechanistic target of rapamycin) inhibitor. As an Active Pharmaceutical Ingredient (API), it is the core component used in the manufacture of pharmaceutical products, primarily to prevent organ transplant rejection. Its mechanism involves binding to FKBP-12 to inhibit mTOR, a key regulator of cell growth and proliferation. This action also underpins its expanding therapeutic applications, including in oncology and cardiology. The API is a white to off-white crystalline powder, insoluble in water, requiring strict control over particle size, purity, and polymorphic form during synthesis to ensure drug efficacy and safety.
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Terbinafine API (Active Pharmaceutical Ingredient) is a synthetic allylamine antifungal compound. It functions by selectively inhibiting the fungal enzyme squalene epoxidase, disrupting ergosterol biosynthesis in the cell membrane, leading to fungal cell death. Primarily fungicidal against dermatophytes, it is the key ingredient in systemic and topical medications for treating onychomycosis (fungal nail infections), tinea pedis (athlete's foot), and other cutaneous mycoses. The API is typically manufactured as terbinafine hydrochloride, a white to off-white crystalline powder. Its broad-spectrum activity, targeted mechanism, and efficacy have made it a cornerstone in antifungal therapy since its introduction.
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Vigabatrin API is the active pharmaceutical ingredient in branded and generic antiepileptic drugs. As a ?-aminobutyric acid (GABA) analogue, it acts as an irreversible inhibitor of GABA transaminase, the enzyme responsible for GABA metabolism. This mechanism increases synaptic GABA levels in the central nervous system, producing an inhibitory, antiepileptic effect. It is specifically indicated for refractory complex partial seizures and infantile spasms. The API is synthesized as a white to off-white crystalline powder, with strict control over chiral purity as the S-(+)-enantiomer is the active form. Its manufacturing requires high-purity standards due to the risk of permanent visual field defects associated with its use.
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Sorafenib tosylate is a small molecule kinase inhibitor active pharmaceutical ingredient (API) used as the critical component in anticancer medications. It works by inhibiting multiple intracellular and cell surface kinases, including those involved in tumor cell proliferation and angiogenesis. Primarily indicated for treating advanced renal cell carcinoma, hepatocellular carcinoma, and thyroid carcinoma, it disrupts tumor growth and spread. The API is a salt form (tosylate) of sorafenib, which enhances its stability and bioavailability for formulation into oral tablets. As a potent targeted therapy, its production and quality control require strict adherence to Good Manufacturing Practices (GMP) to ensure purity, potency, and patient safety.
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Promethazine is a phenothiazine-derived first-generation antihistamine, primarily used for its potent antiemetic, sedative, and anticholinergic properties. Its mechanism involves competitive antagonism of histamine H1 receptors and central dopamine D2 receptors. As an Active Pharmaceutical Ingredient (API), it is the key raw material manufactured to high purity standards for formulation into various dosage forms, most commonly tablets, syrups, and injectable solutions. It is indicated for allergy symptoms, nausea/vomiting, motion sickness, and perioperative sedation. Its use requires caution due to risks of sedation, respiratory depression in children, and extrapyramidal side effects. The API's synthesis, quality control, and stability are strictly governed by pharmacopoeial monographs.
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Roxithromycin is a semi-synthetic macrolide antibiotic derived from erythromycin. As an active pharmaceutical ingredient (API), it acts by binding to the 50S subunit of the bacterial ribosome, inhibiting protein synthesis. It exhibits a broad spectrum of activity against many Gram-positive and some Gram-negative bacteria, including respiratory pathogens like�Streptococcus pneumoniae�and�Mycoplasma pneumoniae. Key advantages include improved acid stability over erythromycin, allowing oral administration without enteric coating, and a long half-life enabling once- or twice-daily dosing. The API is primarily formulated into tablets for treating respiratory tract, skin, and soft tissue infections. Its manufacture requires strict control over polymorphic forms and particle size to ensure consistent bioavailability.
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Pretomanid is an antitubercular agent belonging to the nitroimidazooxazine class. As a pro-drug, its antibacterial activity against�Mycobacterium tuberculosis�is dependent upon bioreductive activation. It demonstrates potent bactericidal activity against both replicating and non-replicating (dormant) bacilli, a key challenge in tuberculosis treatment. Its primary mechanism involves inhibiting mycolic acid biosynthesis, thereby disrupting the bacterial cell wall. Pretomanid is a critical component of the BPaL regimen (alongside bedaquiline and linezolid), approved specifically for the treatment of extensively drug-resistant (XDR) or treatment-intolerant/non-responsive multidrug-resistant (MDR) pulmonary tuberculosis. Its introduction represents a significant advancement in managing complex, drug-resistant TB cases.
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Valganciclovir is an antiviral prodrug, the L-valyl ester derivative of ganciclovir, designed to enhance oral bioavailability. After oral administration, it is rapidly hydrolyzed in the intestine and liver to the active moiety, ganciclovir. As a synthetic guanosine analogue, ganciclovir inhibits viral DNA replication by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, causing termination of chain elongation. Its primary clinical application is the treatment and prophylaxis of cytomegalovirus (CMV) infections, particularly in immunocompromised patients, such as those who have undergone solid organ transplantation or are living with HIV/AIDS. The API is formulated into tablets and oral solutions.
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Procaine is a local anesthetic of the amino ester group, first synthesized in 1905. As a crystalline white powder, it acts by reversibly blocking sodium ion channels in neuronal membranes, inhibiting nerve impulse transmission. Primarily used for infiltration, spinal, and peripheral nerve block anesthesia, it has a slower onset but shorter duration than later agents like lidocaine. Its vasodilatory effects often necessitate co-administration with epinephrine. Procaine is also a component of some parenteral procaine penicillin formulations. While largely superseded by amide-type anesthetics in clinical practice due to allergenicity and stability concerns, it remains a historically significant prototype for modern local anesthetics.
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Selexipag is a non-prostanoid prostacyclin receptor agonist used as an oral API in treating pulmonary arterial hypertension (PAH). It selectively targets the IP receptor, promoting vasodilation and inhibiting smooth muscle cell proliferation, thereby reducing vascular resistance. Structurally distinct from prostanoid therapies, it offers improved stability and oral bioavailability. Its active metabolite, ACT-333679, contributes significantly to its long-lasting pharmacological effect. As the key component in the branded product Uptravi�, the API enables sustained management of PAH symptoms and disease progression. Manufactured under strict pharmaceutical standards, selexipag API ensures consistent quality, safety, and efficacy in final dosage forms.
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Selegiline Hydrochloride is a selective, irreversible monoamine oxidase-B (MAO-B) inhibitor used primarily in the treatment of Parkinson's disease. By inhibiting the breakdown of dopamine in the brain, it enhances and prolongs the therapeutic effect of levodopa. It is also indicated for major depressive disorder at higher doses, where it inhibits both MAO-A and MAO-B. The active pharmaceutical ingredient (API) is typically supplied as a white to off-white crystalline powder, soluble in water and alcohol. Its mechanism provides symptomatic relief in Parkinson's by managing motor fluctuations. Careful manufacturing ensures high purity and stability, which are critical for its efficacy and safety profile in formulated medications.
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Sulfadoxine is a long-acting sulfonamide antibiotic active ingredient (API) used primarily in combination with pyrimethamine for the treatment and prophylaxis of uncomplicated malaria caused by�Plasmodium falciparum. As a competitive inhibitor of dihydropteroate synthase, it disrupts the folate synthesis pathway in parasites. Its extended half-life allows for single-dose or intermittent regimens. The API is a white or almost white crystalline powder, sparingly soluble in water. Manufacturing must adhere to strict pharmacopeial standards (e.g., USP, Ph. Eur.) for identity, purity, and assay. Its use is now geographically limited due to widespread resistance, but it remains a component of Sulfadoxine-Pyrimethamine (SP) in specific public health interventions.
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Tavaborole is a novel oxaborole antifungal agent specifically developed for the topical treatment of onychomycosis (fungal nail infections). Its mechanism of action involves inhibition of fungal protein synthesis. Unlike other antifungals, tavaborole's small boron-containing molecular structure allows it to effectively penetrate the dense keratin of the nail plate to reach the site of infection. It selectively targets and inhibits fungal leucyl-tRNA synthetase, an essential enzyme, leading to the termination of protein synthesis and fungal cell death. Approved as a 5% solution, it offers a targeted, efficacious, and well-tolerated topical option, avoiding the systemic side effects associated with oral therapies.
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Terconazole is a potent triazole antifungal active pharmaceutical ingredient (API) used primarily in the treatment of vulvovaginal candidiasis. It functions by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, leading to increased membrane permeability and cell death. Compared to earlier imidazoles, terconazole offers a broader spectrum of activity and greater specificity for fungal cytochrome P450 enzymes. It is particularly effective against�Candida albicans�and other�Candida�species. As an API, it is formulated into vaginal creams and suppositories, providing localized therapy with minimal systemic absorption, resulting in high efficacy and a favorable safety profile for patients.
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Romidepsin is a potent histone deacetylase (HDAC) inhibitor used as an active pharmaceutical ingredient (API) in anticancer therapy. It is a natural bicyclic depsipeptide, originally isolated from�Chromobacterium violaceum. As a prodrug, its disulfide bond undergoes intracellular reduction to release the active form, which inhibits Class I HDAC enzymes. This action leads to histone hyperacetylation, cell cycle arrest, and apoptosis in transformed cells. The API is specifically formulated for intravenous infusion in the treatment of cutaneous and peripheral T-cell lymphoma. Its complex macrocyclic structure and stability requirements make its synthesis and handling highly specialized.
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Pimecrolimus is a topical calcineurin inhibitor (TCI) used as an anti-inflammatory and immunomodulating active pharmaceutical ingredient (API). A macrolactam derivative, it specifically targets T-cells by inhibiting calcineurin, thereby suppressing the release of pro-inflammatory cytokines. It is primarily formulated as a 1% cream for the treatment of mild to moderate atopic dermatitis (eczema) in patients where conventional therapies are inadvisable. The API offers a non-steroidal alternative, reducing risks associated with prolonged corticosteroid use, such as skin atrophy. Its localized action minimizes systemic absorption, providing a favorable safety profile for sensitive areas like the face and neck.
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