Apex Supplements

DES IGF-1 is the shorter version of the IGF-1 chain. It is five (5) times more powerful than IGF-LR3 and ten (10) times more powerful than regular base IGF-1. The half-life for DES is about 20-30 minutes, which means this is a very delicate chain. Therefore, administration should only be done at the site where you want to see muscle growth. DES has the ability to stimulate muscle hyperplasia better than LR3. In simple terms, it’s best used for site injections, rather than overall growth.

In addition, DES is known to bind to receptors that have been deformed by lactic acid, which is often present during workouts. This allows the DES to attach itself to a mutated receptor and signal tissue growth during training. DES can be used longer and more frequently than LR3. It has been rumored that the first official use of IGF-1 as a performance enhancing drug was in the early 1990s by then-Mr. Olympia Dorian Yates, which at the time was considered an extremely rare and expensive drug to obtain, after which its use quickly spread amongst the bodybuilding community.

IGF-1 DES (reported as des(1-3)IGF-I in scientific studies) is a truncated version of naturally occurring IGF-1. The 70 amino acid form of activated IGF-1 is essential for normal human growth and development and acts via IGF-1 receptors to exert an anabolic effect to build muscle, which is why IGF-1 is important in bodybuilding [1]. Low IGF-1 levels are linked to poor growth and a number of metabolic disorders [2]. Multiple tissues inside the body produce IGF-1 and its site of synthesis affects its function. The majority of IGF-1 is made by the liver and is transported to other tissues in the bloodstream, where it acts as an endocrine hormone [3]. Importantly, IGF-1 is a central growth hormone that controls the anabolic growth promoting effect of growth hormone. It also has a growth hormone independent growth-stimulating effect, which is optimised when combined with growth hormone [4]. IGF-1 DES has been specially formulated to lack three amino acids from the end of natural IGF-1, which increases its potency to around ten-fold higher when compared to regular IGF-1 [5]. This increase in potency is due to the fact that IGF-1 DES does not bind to IGF-binding proteins like IGF-1 [6]. Usually, IGF-binding proteins immediately block the growth-promoting activities of IGF-1, but they are unable to bind and block IGF-1 DES. This means that the peptide is free to promote muscle and bone growth and repair and smooth muscle survival [7, 8]. IGF-I DES has been shown to stimulate body growth in a range of tissues in multiple animal studies [9]. Animal studies have also shown that carcass fat was reduced alongside muscle gains [9]. In diabetic animals the modified peptide demonstrated effects throughout the alimentary tract and led to improvements in nutrient uptake [10]. Although no human clinical trials using IGF-1 DES have been carried out, studies have uncovered that the peptide is naturally found in the human brain and brain cell studies have shown that it can protect against brain damage and that it promotes brain growth .

Our well facilitated infrastructural unit enables us to make a highly qualitative BPC-157 Body Protection Compound, which is developed by making use of excellent quality components.

BPC-157 is an injectable peptide developed for alleviating stomach ulcers. It is characterized by its ability to accelerate the healing of a huge variety of wounds such as skin, cornea, muscle, colon, bone defects and tendons. BCP-157 is a sequence of body protection compound formed of 15 amino acids. Its most remarkable healing properties are granulation tissue (formed at the site of an injury to begin a healing process), angiogenesis (formation of vessels) and production of collagen (a protein that provides structural support, strength, and elasticity to the human body).

How does it work:

Although BCP-157 achieves the healing acceleration by an unknown mechanism, there are some hypotheses involving the regulation of growth factor, proangiogenic effects, and modulation of nitric oxide synthesis. Furthermore, it is related to a bone morphogenetic protein that allows the formation of new bone, cartilage, and tissue. In addition, the potential reason for tendon healing is that BC P-157 treats tendon fibroblasts.

Results and benefits:

BCP-157 has shown impressive results with regards to healing. Some injuries that take more time to recover are those related to muscles and ligaments. This protein allows faster healing process bringing an excellent advantage to injured athletes to achieve their recovery in less time. There is a specific benefit involving the regeneration process of tendon-to-bone using BCP-157, while this kind of injury requires individuals to undergo a reconstructive surgery. As already mentioned, regeneration of the tendon is due to the fibroblasts, which provides hardness and elasticity. Not only tendons but bones are also benefitted by BCP-157. Some studies have shown increase of the tendon that there are a variety of protective effects in the human organs, such as pancreas, liver injuries endothelium heart damage and pseudarthrosis, making it a multifunctional peptide capable of bringing a huge amount of benefits to the humans.

There are no toxic effects on the use of BCP-157 in humans nor other adverse reactions have been found during tests, which represents a high grade of safety and reliability for human consumption.
BPC-157 is water soluble resistant and considered a good treatment for gastric ulcers along with its anti-inflammatory effects; it facilitates the supply of blood to an ulcer to get a faster healing.

Other tests have shown a positive effect against convulsions, bringing BCP-157 anti-convulsive properties. Its effects are directly related to the dose and the time it takes to perform its function in the body.

Although BPC-157 has lots of benefits and advantages over other compounds, it is illegal to sell it for human purposes. The main reason for the use of peptide is the need to find a solution for gastric problems but after much research and a variety of tests, BPC-157 has been declared as a promising substance to heal the human body.

Research indicates that an adequate dose range for humans is 200 to 500 mcg for healing purposes but lower doses of 0.1 mcg also perform better.
 

The administration of recombinant human GH (rhGH) has been approved by the FDA and various international regulatory agencies for several indications both in children (GH deficiency (GHD), Turner syndrome, children born short for gestational age, Prader-Willi syndrome, idiopathic short stature, etc.) and in adults (GHD, HIV-associated lipodystrophy, etc.) [1]. Treatment with rhGH is routinely performed as one subcutaneous daily injection, thus it does not resemble the physiological pulsatile pattern of GH release. On the other hand, the administration of GHRH or its analogs results in increased levels of GH in serum and more importantly, maintenance of the episodic pattern of GH secretion. In addition, contrary to rhGH administration which contains only the 22kDa isoform of GH, therapy with GHRH-type molecules should result in the secretion of all forms of GH that are produced in the pituitary somatotropes (including post-translationally modified isoforms whose functions remain unknown [2]).

A major obstacle in assessing the efficacy of GH therapy is the lack of a consistent biological serum biomarker. Levels of IGF-1 and IGFBP-3 are widely used to monitor the efficacy of GH therapy, but unfortunately, there is considerable variability in responses (growth velocity, final stature, glucose tolerance, insulin levels, etc.) with a lack of consistent correlation between the measured response and the serum levels of GH, IGF-1, IGFBP-3, etc. Collagen peptides are also used as biomarkers of GH activity, but again their reliability as predictors of treatment efficacy is variable [3]. The abuse of rhGH by athletes to improve performance is also a major concern, and underscores the need for new and more specific biomarkers of GH action [3-7]. Moreover, the finding of new biomarkers will expand our understanding of the molecular mechanism and physiologic effects of GH action.

In a previous study, the long-acting GHRH analog CJC-1295 was shown to promote an increase in GH and IGF-1 levels in sera of healthy young adult men one week after administration, without affecting the pulsatility of GH secretion [8]. The extended half-life of the compound (8 – 10 days in humans) is due to its ability to bind to endogenous serum albumin through a free thiol group forming a covalent disulfide bond [9]. The present study was designed to identify biomarkers of GH and/or IGF-1 action in serum samples obtained before and one week after administration of CJC-1295 to healthy subjects. The samples were analyzed using a proteomic approach to search for serum proteins and protein isoforms that respond to increases in GH or IGF-1. Five protein spots displaying significant changes after treatment were identified and their serum levels evaluated for correlations to GH and IGF-1 serum concentrations.

• Testosterone Enanthate 200mg/2ml
• Boldenone Undecylenate 150mg/2ml
• Nandrolone Decanoate 150mg/2ml

Usage: Complete Bulking stack developed for massive Muscles and Strength gain. 500mg of bad ass bulking steroids can be used with all other non-steroidal anabolic such as SARMs and Peptides for inhuman muscle mass and unbelievable power.

Additional Information:

• Delivery Time: 2 to 3 days

What are the benefits of using GHRP 6?

While all that stuff about how it works might be a bit complicated, the benefits of GHRP 6 aren’t so hard to wrap your head around.

They are:

1. Increased muscle growth

GHRP 6 promotes the release of growth hormones. With that being the case, your work is half done. All you need is to combine this effortless release of growth hormones with a good exercise and diet regimen. Your body will start building your muscles at a much faster rate, thanks to the growth hormones.

1. Higher rates of fat loss

Alongside helping you release growth hormones, GHRP 6 helps to boost your metabolism. This automatically improves your metabolic processes, which include fat burning. As such, you’d be able to burn through your cholesterol much faster than usual.

1. Anti-aging effects

One of the most impressive things about GHRP 6 is that it boosts your collagen production levels. This means that your skin will be able to retain its elasticity, you won’t have dark spots and nasty scars so easily, your wounds will heal faster, and so much more. Basically, you’d look younger and much fresher with GHRP 6.

CJC1295DAC relates to tetrasubstituted peptide hormones, whose structure consists of 30 amino acids. The main purpose of this peptide is to stimulate the production of growth hormone. The peptide is available in injectable form and is used in standard practice medicine as well as in the sports medicine.
 
The main advantage of CJC1295DAC  is its continuous half-life, which lasts up to 2 weeks in certain circumstances. It has the ability to contact with the plasma protein so the effect of active substances increases significantly. This peptide is popular among the athletes who are forced to stop their trainings for a while but want to keep their shape and relief of muscles.
 
The usage of CJC1295DAC helps to speed up the period of recovery after serious injuries. Additionally this peptide helps to reduce the amount of fat tissue and increase muscle mass, even without training.
 
THE EFFECTS OF THE USE OF CJC1295-DAC
Increase in endurance and strength
Increase in number of muscle cells
Body fat reduction
Increase of bone tissue density
Reduction of possibility of ligament and cartilage injuries
Sleep quality improvement
 
The apparent increase of the muscle tissue due to its swelling is noted during the course of the CJC1295 DAC and it has been confirmed by numerous positive reviews of the peptide.

What Is HGH191AA?

• HGH191AA (Human Growth Hormone 191AA) is a peptide used in activating the human growth hormone (HDH). The pituitary gland (hypophysis), which is an endocrine gland, produces the HGH191AA, and it’s created by 191 amino acids. The main function of the Human Growth Hormone 191AA involves the deposition of proteins, the growth of tissues as well as the subcutaneous fat stores’ breakdown.

During adolescence, Growth Hormone is normally produced at high levels. Treatments that use that peptide are generally focused on the battle against a medical condition known as growth hormone deficiency (GHD).

How It Works: 

• The mechanism of GHRH (Growth Hormone-Releasing Hormone or also known as somatocrinin) causes the secretion of HGH during sleep. Also, this process stimulates somatostatin production. Somatostatin is also called GHIH (growth hormone-inhibiting hormone), and it’s a peptide hormone that usually regulates the endocrine system plus inhibits glucagon and insulin secretion.

Human Growth Hormone 191AA enhances anabolism a metabolic pathways set that allow molecules construction from smaller units) and promotes the growth of your body cells, hence it, in turn, increases these cells multiplication rate.

IGF-1 LR3 is a synthetic peptide and lengthened analogue of human insulin-like growth factor 1. With a half-life of between 20 and 30 hours it is three times as effective as HGF1. Human insulin-like growth factor 1 is a protein hormone, and in the body, it’s produced naturally in the liver. It functions a little like insulin. Its effect is to move nutrition into the muscle cells. When it reaches those cells, it is used to build and repair muscle tissue. Importantly, it stimulates the growth of new muscle tissue, unlike other supplements which only work to repair existing tissue. It also operates on connective tissue, in the digestive system, particularly the intestines, and in the bones.
GF-1 LR3 works throughout the body, not just in the muscle area where it is injected. Don’t think that you can inject into a muscle area which you want to develop, and IGF-1 LR3 will just work on that specific area. It will work to enhance and promote muscle growth throughout your body.
The recommended dosage for men of IGF-1 LR3 is 40 – 50 mcg each day. For women, the suggested dose is much lower at 20mcg. Administration is via subcutaneous (under the skin) or intra muscular (into the muscle) injection. You should take your dosage once per day, or if you prefer you can split your dose and take it twice a day. Some athletes prefer this more continuous stream of IGF-1 LR3. The best time to administer your dose on a day when you will be in training is either before or after you exercise. On non-training days, you can take your dosage at any time that is convenient to you.
You should take IGF-1 LR3 for a maximum for thirty days at a time, and then take a break of no less than two weeks. A longer period than two weeks is ideal, as this allows your body to fully return to the sole use of its own natural hormones.

IGF-1 LR3 is an effective agent for the repair and rebuilding of muscles. Used correctly it can help you bulk up, recover from injury more quickly and is a general aid to your training program. Its benefits as against other supplements are that it is very powerful and fast acting.
The effects of IGF-1 LR3 are enhanced by a good and careful diet, with a healthy balance between excellent protein sources, fats, vegetables and fruits, with a minimum of carbohydrates and sugars. You can continue to train as normal when using IGF-1 LR3.

IGF-1 LR3 is all about repairing and building muscle. It was first used in the sports area by body-builders during the 1990’s, and has been a popular choice ever since for those people wishing to improve their bulk, power and performance.
If used as suggested, IGF-1 LR3 shows no adverse effects for most users. It can lead to slightly lowered insulin levels, so those with a disposition to diabetes should monitor themselves carefully while using IGF-1 LR3. Because this is such a powerful and potent tool for those seeking to improve their athletic performance, dosage guidelines and pauses in treatment periods should be closely observed.

IGF1 LR3 is also known as Long R3 IGF-1 or Insulin-Like Growth Factor-I Long Arg3. The Long R3 IGF-1 version is significantly more potent than regular IGF-1. The enhanced potency is due to the decreased binding of IGF1 LR3 to all known IGF binding proteins.

IGF-1 is basically a polypeptide hormone that has some of the same molecular properties as insulin. IGF dose actually stand for insulin-like growth factor. IGF-1 is mainly responsible for long bone growth in children and it also affects muscle growth and repair of adults. Long R3 IGF-1 is a more potent version of IGF-1. It’s chemically altered i like to think “enhanced” to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min… So that means a far more effective version than the short chain we were perhaps more familiar with.

What is the GHRP 6?
The Growth Hormone Releasing Hexa Peptide is a synthetic substance containing amino acids. Its primary function is to stimulate the secretion of growth hormones in your body.
Thus, leading to an increase in muscle mass.
How exactly does it work?
If you’re more curious about the scientific details of how this synthetic hexapeptide works, then let’s explain.
Now, GHRP 6 has about six different amino acids within its sequence. This sequence containing amino acids sends signals to your brain to send out growth hormones from your pituitary gland. It does all this while preventing your body from releasing Somatostatin.
As soon as that’s done, the growth hormone that’s been released sends a signal to the liver. Once received, the liver begins secreting the Insulin-like Growth Factor (IGF-1), an anabolic hormone.
When the IGF-1 (muscle growth peptide) has been released, the GHRP would’ve done its job, and your body would begin enjoying the benefits of the whole process.
What are the benefits of using GHRP 6?
While all that stuff about how it works might be a bit complicated, the benefits of GHRP 6 aren’t so hard to wrap your head around.
They are:

Increased muscle growth

GHRP 6 promotes the release of growth hormones. With that being the case, your work is half done. All you need is to combine this effortless release of growth hormones with a good exercise and diet regimen. Your body will start building your muscles at a much faster rate, thanks to the growth hormones.

Higher rates of fat loss

Alongside helping you release growth hormones, GHRP 6 helps to boost your metabolism. This automatically improves your metabolic processes, which include fat burning. As such, you’d be able to burn through your cholesterol much faster than usual.

Anti-aging effects

One of the most impressive things about GHRP 6 is that it boosts your collagen production levels. This means that your skin will be able to retain its elasticity, you won’t have dark spots and nasty scars so easily, your wounds will heal faster, and so much more. Basically, you’d look younger and much fresher with GHRP 6.
What are the potential side effects of GHRP 6?
While this supplement has astounding benefits, we cannot deny the side effects either. Thankfully, they’re all mild and/or temporary.

Increased levels of hunger

Because the drug mimics ghrelin, it could make you feel hungrier than usual.

Pain in the joints

This is a very temporary side effect of using the drug. It happens because of how much more cortisol you have in your body when you use GHRP 6. The pain should be gone in no time.

Headache and dizziness

This could show up due to the stimulation of growth hormones.

Pentadecapeptide BPC 157, composed of 15 amino acids, is a partial sequence of body protection compound (BPC) that is discovered in and isolated from the human gastric juice. Experimentally it has been demonstrated to accelerate the healing of many different wounds, including transected rat Achilles tendon. 

The effects of the BPC-157 use

The growth of muscle tissue

Increased strength and endurance of the athletes and bodybuilders

Muscle tone increase

Fast body recovery after workouts

Acceleration of metabolism on the cellular level

Anti-inflammatory effect

Positive reviews of the peptide BPC-157 clearly show the effectiveness of the peptide during workouts and recovery after injuries or diseases. Its composition is also completely analogous to the natural peptide, it is not prohibited and can not be interpreted as doping.

Administration course of BPC-157 peptide lasts from 2 to 3 months on average. In order to achieve the maximum effect it can be roughly divided into two phases - loading and support phases.

Loading phase: 300 mcg a day. Phase duration: 1 month.

Support: 200 mcg also used within one day. Duration: 1 - 2 months.

The injections are administered intramuscularly or subcutaneously strictly adhering the solution preparation instructions.

Benefits of Copper Peptide

CJC-1295 DAC has shown some amazing results as a growth hormone releasing hormone (GHRH) analog. Not only has CJC-1295 shown the ability to increase growth hormone and IGF-I secretion and its benefits, but it has been able to do so in very large amounts. Recent research studies have shown that CJC – 1295 stimulates GH and IGF-1 Secretion, and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to intense fat loss, and increases protein synthesis.

CJC-1295 W/DAC is a long acting Growth Hormone Releasing Hormone, which causes the anterior pituitary  to release more growth hormone. GHRH is released in pulses in the body, which alternate with corresponding pulses of somatostatin (growth-hormone inhibiting-hormone). Clinical Research was first conducted for CJC-1295 during the mid-2000s. The objective of the peptide was to treat visceral fat deposits in obese AIDS patients, as increased levels of exogenous hgH are presumed to increase lipolysis (fat loss). The clinical research was ultimately successful for most research subjects. Ghrelin, released from the gut, which circulates and acts as a hunger hormone, has synergistic activity in the body with GHRH and also suppresses somatostatin to make way for the GHRH pulse. Studies shows that combining a GHRP-6 or MK677 with CJC 1295 DAC, significantly increase the release of GH and IGF-1 production without an increase in prolactin. An example of a GHRP (GH Releasing Peptide) is Hexarelinor GHRP-2. CJC 1295 DAC is a exceptionally designed peptide and is known for being the finest of the HGH secretogues. The DAC (Drug Affinity Complex) portion increases the half-life from a couple hours to several days.

Dosages:

For physique or performance enhancing purposes, CJC-1295 is generally administered at a dosage of 1-2 mg once or twice a week. Cycles usually last 3-4 months.

Remember:

You must mix with BAC water before use.

• • Strong anabolic effect and ability repair and rebuild muscles
  • Ability to induce muscle hyperplasia (growth of new muscle cells)
  • Neuro-protective effect (protects the nervous system and brain functions)
  • Mediates myocardial cell survival and myocardium repairs
  • Important roles in tissue growth and wound healing
  • Positive role on bone injury healing

IGF-1 DES (1-3), short for Insulin-Like Growth Factor-1 DES 1 – 3, is one of the most popular peptides available, as is the conventional IGF-1 LR3. It generates new muscle cells and thereby affects muscle growth enormously. Compared to the conventional IGF-1 LR3, IGF-1 DES (1-3) is said to be stronger, faster and more fat-burning.

IGF-1 DES (1-3) is a truncated variant of the conventional IGF-1 with a so-called tri-peptide structure. It has been purposefully isolated so that it can be more effective in certain tissue types. Due to the altered structure, IGF-1 DES (1-3) is 10 times more potent than IGF-1 in the hypertrophy and proliferation of so-called satellite cells in muscle tissue and other tissues. In addition, it should have a much more metabolic, fat-burning effect than conventional IGF-1.

As such, IGF-1 normally occurs when testosterone, HGH (growth hormone) and insulin meet in the liver. IGF1 does not just provide muscle growth, but the formation of completely new muscle cells. This results in the new formation of completely new muscle mass.

Effect:

The effect of IGF-1 DES (1-3) is four times faster than that of conventional IGF-1, although the fat-burning effects last three to five times longer than those of conventional IGF-1. This is related to the fact that IGF-1 DES (1-3) is subsequently found in higher concentrations in the target tissue than IGF-1. Originally, IGF-1 DES (1-3) was made for inflammatory inflammation and intestinal disorders, as it specifically targets intestinal tissue strength. In addition, IGF-1 DES (1-3), like other forms of IGF-1, is used in the treatment of catabolic effects in general or certain diseases.

TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. The main purpose of this peptide is to promote healing. It also promotes creation of new blood and muscle cells. The healing effects of TB-500 have been observed in tendons, ligaments, muscle, skin, heart, and the eyes. Thymosin beta-4 is naturally produced in higher concentration where tissue has been damaged. This peptide is also a very potent anti-inflamatory agent.

TB-500 is different from other repair factors (growth hormone, IGF-1), because it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight. Because of this it can travel long distances through the tissues in the human body.

One of TB-500 key mechanisms of action is its ability to regulate the cell-building protein – Actin. Of the thousands of proteins present within human cells, actin represents roughly 10% of the total. It is thus a vital component of cell structure and movement.

Additional Information:

• Delivery Time: 2 to 3 days