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Corion is a state of the art, ISO certified, Infertility clinic, located in a quiet residential area in Andheri, an easily accessible and busy suburb of western Mumbai. Established in the year of 2010, the clinic is the first in the Western region to have a world class laboratory which strictly follows the international quality standards and stays committed to deliver the best to its patients. The moment one enters the clinic, the ambience of the clinic generates a feeling of warmth and positivity that immediately removes all the anxieties and puts one at ease. The courteous staff is very welcoming and is ready to take care of your smallest needs. All services right from an initial fertility work up involving an examination and blood tests to undergoing endoscopic surgeries and In vitro fertilisation (IVF) or Intra Cytoplasmic Sperm Injection (ICSI) and Embryo and Sperm cryopreservation is done under one roof. Dr. Kaushal Kadam, the Medical Director, who has been in this field for more than a decade and has given joy of becoming parents to numerous couples, personally takes care of each patient right from the time they come for their initial consultation to ultrasounds and finally their pregnancy test. This is what makes her clinic, Corion, unique as the delicate parts of the treatment are not handed over to other IVF staff members but taken care of by her. She has been known for her dedicated approach in this field and her clinic excels in treatments for third party reproduction including Surrogacy. Her personal interest lies especially in the treatments for the poor responders and those with repeated IVF failures. Corion is therefore always trying different stimulation protocols and improvising their laboratory techniques to maximise their success rates. The center has a dedicated Team of ART specialists including embryologists, counsellors, secretariat and other nursing and technical staff.+ Read More

Nature of Business

Service Provider

Year of Establishment

2010

Laser Assisted Hatching
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Laser Assisted Hatching

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Laser Assisted Hatching in ART Procedures
  • The laser assisted hatching is an additional lab technique designed to improve the efficiency of assisted reproductive technology procedures such as IVF & ICSI.
  • The unfertilised egg is surrounded by a shell called zona pellucida The zona has an important role in fertilisation as it allows only one to penetrate the zona and enter the egg to achieve fertilisation.
  • After fertilisation of the egg, during the cleavage stage of an embryo, zona pellucida hardens. This development is normal and the purpose is to keep the cells in the egg together.
  • The embryos have to "hatch" or break out of the zona in order to embed into the endometrium lining of the uterine cavity. This occurs about 2-3 days after embryo transfer when the embryo is at the blastocyst stage. Naturally this takes place by expanding/contracting of the zona until it distorts, allowing the blastocyst to "hatch".
  • When and eggs are cultured in IVF laboratory, the zona pellucida hardens at much faster rate than natural, making it more difficult for the embryo to implant.
  • Prior to implantation, the embryo has to escape out of its zona pellucida by a process known as hatching. If this process is not completed properly, implantation failure occurs and a pregnancy can not be achieved.
  • Assisted hatching is the process of creating a hole in zona pellucida, to aid the embryo in the hatching process.
  • At Corion Fertility Clinic, we offer the Laser technology for Assisted Hatching (LAH), where a precision laser beam is focused over the zona pellucida making a small opening, between 10-20 microns to facilitate embryo hatching. LAH is done just before the Embryo Transfer.
  • This helps to increase pregnancy rates by improving implantation rates, since embryo hatching is facilitated.
  • A fast, safe, simple method compared to the old method of hatching which was performed by using acidic medium (expelled onto the zona to create a small hole).
  • The accuracy of the laser is predetermined by its programming, and is therefore not dependent on the skill of the operator. There is a high degree of reproducible accuracy.
  • We also recommend that thawed embryos should be treated with laser assisted hatching before Embryo Transfer to maximise success rates.
Who might benefit
  • Patients with day 3 embryos having a thick Zona.
  • Patients with failed previous IVF/ICSI cycles.
  • Women older than 37 years of age, have a tendency to produce eggs with a harder zona pellucida than younger women.
  • Women with a high Follicle Stimulating Hormone (FSH) level.
  • Patients undergoing IVF/ICSI for the first time, who are considered poor responders because they have required a high dose of gonadotropins for poor ovarian response.
  • Patients who in an earlier IVF cycle had low fertilisation rate, resulting in three or fewer embryos.
  • Patients who request laser assisted hatching and are fully informed of its use and function.

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Blastocyst Transfer
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Blastocyst Transfer

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At CORION, IVF laboratory is proficient at blastocyst culture
  • At CORION, the IVF laboratory is proficient at blastocyst culture.
  • Our IVF laboratory has excellent quality controls and is therefore able to do a day 5 blastocyst transfer.
  • A blastocyst is an embryo that has been allowed to develop in the laboratory for five or six days after egg collection. This is in contrast to standard IVF where embryos are only allowed to develop up to day two or three in the laboratory, before being transferred to the uterus.
  • The outer sphere of the blastocyst is called the Trophoblast.
  • The inner portion of the blastocyst is filled with fluid.
  • Inside the trophoblast, there is a clump of cells called the Inner Cell Mass (ICM). The inner cell mass is the portion of the blastocyst that actually becomes the baby.
  • Only a small percentage of embryos will reach the blastocyst stage. This self selection of the embryos allows the embryologist to pick the embryos that are most likely to produce a pregnancy.
  • While transferring blastocysts, fewer embryos are transferred as compared to day2 embroys. This reduces the risk of multiple pregnancy.
  • Major potential benefit of transferring blastocyst following IVF is reduction of the possibility of multiple pregnancy.
  • This is true for all age groups.
  • The rationale behind a blastocyst transfer is that an embryo which has failed to reach the blastocyst stage, would be unlikely to have resulted in a pregnancy. However, if it reaches the blastocyst stage it has about 50% chance of implanting. So the improved implantation rates following blastocyst transfer is due to selection of the best embryos.
  • Two main reasons why 50% blastocysts fail to implant : A defective blastocyst (e.g. chromosomal abnormalities) or non-receptive endometrium
  • However, if the culture environment is suboptimal, delayed embryo development and even embryonic arrest will occur.

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Vitrification & Frozen Embryo Transfer
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We run a very successful Cryopreservation Program, the success rates of which are similar to our fresh transfer cycles. This is possible with the latest method of an ultra-rapid flash-freezing protocol called Vitrification where a very high concentration of cryoprotectant is used. The embryos/oocytes are plunged directly into the liquid Nitrogen. The result is a solid glass-like cell, free of ice crystals. Vitrification cools the cells in an extraordinarily faster speed greater than 15.000º C per minute so that there is no time for ice crystals to be formed, but instead a kind of gel appears leaving the cells undamaged. In the classical freezing method, embryos were slowly cooled at a rate of 0´3º degrees per minute in order to avoid ice crystal formation around & within the cells. At Corion, we cryopreserve all our embryos & oocytes by Vitrification method only.
This is because Vitrification offers improved survival rate of the embryos as well as oocytes as compared to classical slow freezing method. This results in better rates of implantation & pregnancy. To check our success rate of Frozen Embryo Transfers kindly check our webpage Success Rates Frozen Embryo Transfer When planning a frozen embryo transfer, the endometrium of the uterus is prepared through oral medication. The frozen embryos are thawed the day before the planned embryo transfer or on the same day depending on whether it is a Day 3 or Day 5 Embryo transfer. We also perform Laser Assisted hatching on thawed embryos just prior to embryo transfer to increase the Implantation Rate. The pregnancy rate of Frozen Embryo Transfers at our clinic is approximately 40-45%. We also accept embryos from overseas for transfer into surrogates (surrogacy program) in India. Our clinic runs a successful Cryoshipper Program and we can help you ship your embryos to us. You can read more about this at our webpage Cryoshipper Progarm.

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Ovulation Induction
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Ovulation Induction

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Ovulation induction is the stimulation of the ovaries to produce multiple follicles, each containing an egg.
Ovarian stimulation involves the use of fertility medications that promote the simultaneous maturation of multiple follicles. During the ovarian stimulation stage, the woman's progress is monitored with hormone testing and ultrasound.
Ovulation inducing agents are either in pill form (Citrate) or injectable form (Gonadotropins) A Fertility Specialist also known as a Reproductive Endocrinologist prescribes such medication. They are usually given by self-injection. The Fertility Specialist might recommend an adjunctive therapy when using gonadotropins, such as ovarian "down-regulation" with a drug called Lupron to get a better response from the ovaries. If a patient is using daily injections of gonadotropin for ovulation induction, she needs frequent monitoring with vaginal ultrasound. A nurse coordinator assigns a date for a vaginal ultrasound and blood test around the time the period starts. In a typical stimulation protocol, daily injections of human gonadotropins, is started after the menstrual period. These medications are concentrated forms of the natural hormones, which stimulate ovulation in a normal menstrual cycle. The day gonadotropins begin is stimulation day 1, or "stim day 1" regardless of when it occurs after the period. The follicles are egg-containing areas inside the ovary. There are hundreds of thousands of follicles in each ovary, but during any one stimulation cycle only a few will accumulate fluid and grow large enough to appear on an ultrasound exam. Only the large follicles hold mature eggs. Each follicle usually contains one egg surrounded by granulosa cells. Granulosa cells surround the egg, produce the follicular fluid, produce estrogen, and support the egg in its development. Gonadotropins cause several follicles to enlarge at once. The number can vary from one or two to 30 in some women. Women who are very sensitive to the medication need only a small amount of gonadotropins, while those who are resistant require more. When ultrasound examination and estrogen levels suggest that the follicles are large enough and the eggs are mature, patient will be advised to stop gonadotropins and take one dose of human chorionic gonadotropin (hCG). hCG prepares the eggs for ovulation and fertilization. Egg retrieval is performed at about 36 hours after hCG, since ovulation normally begins about 40 hours after the hCG injection. The timing of hCG is critical, so it must be taken at the exact time you are instructed to take it.

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Follicular Monitoring
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Follicular Monitoring

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Follicular Monitoring is the process of serial ultrasonic monitoring of the ovarian follicles used to identify maturation status of eggs. It is useful for assessing the size of the follicle that supports the growing egg and for determining the thickness of the uterine lining. In women taking fertility medication, follicle monitoring is essential to assess her response to treatment. In order to safely proceed, it is important to know how many eggs will ovulate and how high the estradiol level is. Each mature egg should produce between 150 and 200 pg/ml of estradiol. Therefore, by using the hormone levels in conjunction with the ultrasound exam, a more accurate determination of a woman's response to treatment can be made. Additionally, the dose of the fertility medication can be adjusted during treatment if there is an inadequate response or if too many eggs start to mature. If the estradiol level gets very high, a woman may be at an increased risk for developing ovarian hyperstimulation syndrome. The goal of follicle monitoring is to provide information about the number of mature eggs that will ovulate and to ensure that this is accomplished safely. When the eggs are mature, patients are advised to have planned relations, or Intrauterine Insemination or proceed with egg collection in case of an In-Vitro Fertilization Cycle. Ultrasound Monitoring enables the Doctor to understand present status of the uterus, endometrium and ovaries. Abnormalities in these findings could help to explain why a woman may have difficulty conceiving. It also identifies ovarian cysts, pelvic collection, hydrosalpinx etc. Dr. Kaushal Kadam does all follicular monitoring at Corion, starting from baseline scan on day 2 followed by Day 6 & Day 9 after which patient is ready for further management. Thus patient needs to come to the clinic for a maximum of 3-4 visits.

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DNA-ID check
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DNA-ID check

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At Corion, we send our patient's samples for DNA-ID Check to DNA Diagnostics Centre (DDC), USA where this highly specialised testing is performed at a very affordable fee. You can rely on your paternity test results from DNA Diagnostics Centre because of the highly efficient laboratory they have. DDC is an International Organization for Standardization (ISO) certified laboratory as per ISO/IEC 17025 standards. The American Association of Blood Banks (AABB), an organisation that demands the highest standards in DNA testing, also accredits it. DNA (deoxyribonucleic acid) is the genetic blueprint that determines a person's biological characteristics. It is located in every nucleated cell of the human body. Upon conception, a child inherits one half of his DNA from his mother and one half from his father. The unique combination of DNA, once analysed, will match that of the biological parents. When a paternity test shows that a child's DNA DOES NOT match that of the alleged father, he is excluded as the biological father of the child. When the child's DNA DOES MATCH that of the alleged father, we can prove a probability of 99% or greater for paternity. To arrive at a probability of paternity, human cells are first extracted from the tested parties. Cheek cells are collected from the mouth with a buccal swab. In the laboratory, these cells are removed from the swab. The DNA from these cells is then extracted, and cut into sample fragments with enzymes. These fragments are placed into a gel matrix, where an electric current drives the fragments across the gel. Later in the process, these fragments are exposed to a labeled DNA probe. This probe recognizes and binds to a unique segment of the person's DNA. Where this probe binds to each person's DNA is the key to establishing relationships. A film is developed which will reveal black bands wherever the probe has bound to the individual's DNA. The pattern of a child is unique - half matches the mother and half matches the father. If it is revealed that the band patterns of the alleged tested father/mother DO NOT match that of the child, that person can be conclusively excluded as the child's father/mother. If the patterns DO match, the probability of paternity begins to grow. DNA testing is very scientific, and very accurate. We at Corion are able to provide sterile kits for the couples to get the test done or alternatively you can get your child to our clinic & our trained laboratory personnel will help you collect the swabs. The swabs will then be couriered by us to DDC & you can expect the report in a week to 10 days time.

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Recurrent Pregnancy Loss

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Miscarriage is the loss of a pregnancy before viability. Occurring in 15-20% of all pregnancies, it is the most common complication of pregnancy. The individual risk may vary depending on age and other factors. The unfortunate fact of miscarriages is that the vast majority of them are not preventable because they are due to developmental or genetic problems in the embryo or fetus that cannot be treated. Recurrent Pregnancy Loss (RPL) or Recurrent Miscarriage (RM) affects from 1-5 % of the reproductive age couples.

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