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144188195215245280

Crystalin Research Private Limited

Hyderabad, Telangana

| GST  36AAECC3571B1Z1

| Verified Supplier

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Incorporated in the year 2011 at Hyderabad, Telangana, we “Crystalin Research Pvt Ltd” are engaged as the service provider of Calorimeter Analytical Service, Dynamic Vapor Sorption Analytical Service and many more. We render this service by keeping the preference of clients in mind. We offer the expertise and experience of academics to industry for innovative solutions to pharmaceutical solid-state issues. Over 80% drugs and 95% of top-selling drugs are administered as tablets/ capsules. All drugs coming through development in the last 10 years have many polymorphs and pseudopolymorphs.   Our firm is a new scientific enterprise started at the Technology Business Incubator facility on University of Hyderabad campus. Crystalin will leverage Scientific Inventions and Innovations through Pharmaceutical R&D and transform into platform technologies and novel drug products. We provide reliable solutions to polymorphism and crystallization problems through in-depth knowledge and expertise of the solid-state for over a decade. Our motto is to create Intellectual Property through R&D.   The business theme of Crystalin is Chalk2Salt - to take insoluble drug molecules like chalk dust and transform them into high solubility solid forms as table salt. The discovery of novel drug forms and selection of the stable formulation is the research theme of its founder Professor Ashwini Nangia, author of over 200 research publications and a dozen patents.
Ongoing Projects:
Temozolomide: Chemotherapy for glioblastoma multiforme (gbm) Primary malignant brain and cns tumor Approved for treatment of malignant glioma in us and eu in 1999. patent expires in 2014 Frst drug licensed for treatment of malignant glioma in past 30 years Temodar/ temodal is schering-plough molecule Discovered at aston university in 1980 Tmz prodrug. active species is mtic (ch3n2 ) White samples of temozolomide stored at 45% rh turned pink after 24 hours and the material was distinctly tan after 4 days indicating decomposition There is a need to make stable temozolomide form   Furosemide (Lasix): Loop diuretic drug commonly used in the treatment of hypertension and edema. Bcs class iv drug. solubility 6 mg/l in water and permeability log pow 1.4 The highest dose strength of furosemide is 80 mg, i.e. do number of 53   Clotrimazole: Antimycotic imidazole effective against a wide range of fungal pathogens Diverse biological actions Effectively and rapidly inhibits growth of plasmodium falciparum strains in vitro Active against chloroquine sensitive strains and functions as effective antimalarial But clt has poor aqueous solubility (< 1 mg/l) and is hydrolyzed in acidic medium Antimycotic imidazole effective against a wide range of fungal pathogens Diverse biological actions Effectively and rapidly inhibits growth of plasmodium falciparum strains in vitro Active against chloroquine sensitive strains and functions as effective antimalarial But clt has poor aqueous solubility (< 1 mg/l) and is hydrolyzed in acidic medium   Norfloxacin and Ciprofloxacin: Broad-spectrum antibacterial agents Currently marketed solid dose of norfloxacin is bcs class iv Fluoroquinone–cooh cocrystals of improved solubility and stability crystallized
...Read More

Incorporated in the year 2011 at Hyderabad, Telangana, we “Crystalin Research Pvt Ltd” are engaged as the service provider of Calorimeter Analytical Service, Dynamic Vapor Sorption Analytical Service and many more. We render this service by keeping the preference of clients in mind. We offer the expertise and experience of academics to industry for innovative solutions to pharmaceutical solid-state issues. Over 80% drugs and 95% of top-selling drugs are administered as tablets/ capsules. All drugs coming through development in the last 10 years have many polymorphs and pseudopolymorphs.   Our firm is a new scientific enterprise started at the Technology Business Incubator facility on University of Hyderabad campus. Crystalin will leverage Scientific Inventions and Innovations through Pharmaceutical R&D and transform into platform technologies and novel drug products. We provide reliable solutions to polymorphism and crystallization problems through in-depth knowledge and expertise of the solid-state for over a decade. Our motto is to create Intellectual Property through R&D.   The business theme of Crystalin is Chalk2Salt - to take insoluble drug molecules like chalk dust and transform them into high solubility solid forms as table salt. The discovery of novel drug forms and selection of the stable formulation is the research theme of its founder Professor Ashwini Nangia, author of over 200 research publications and a dozen patents.
Ongoing Projects:
Temozolomide: Chemotherapy for glioblastoma multiforme (gbm) Primary malignant brain and cns tumor Approved for treatment of malignant glioma in us and eu in 1999. patent expires in 2014 Frst drug licensed for treatment of malignant glioma in past 30 years Temodar/ temodal is schering-plough molecule Discovered at aston university in 1980 Tmz prodrug. active species is mtic (ch3n2 ) White samples of temozolomide stored at 45% rh turned pink after 24 hours and the material was distinctly tan after 4 days indicating decomposition There is a need to make stable temozolomide form   Furosemide (Lasix): Loop diuretic drug commonly used in the treatment of hypertension and edema. Bcs class iv drug. solubility 6 mg/l in water and permeability log pow 1.4 The highest dose strength of furosemide is 80 mg, i.e. do number of 53   Clotrimazole: Antimycotic imidazole effective against a wide range of fungal pathogens Diverse biological actions Effectively and rapidly inhibits growth of plasmodium falciparum strains in vitro Active against chloroquine sensitive strains and functions as effective antimalarial But clt has poor aqueous solubility (< 1 mg/l) and is hydrolyzed in acidic medium Antimycotic imidazole effective against a wide range of fungal pathogens Diverse biological actions Effectively and rapidly inhibits growth of plasmodium falciparum strains in vitro Active against chloroquine sensitive strains and functions as effective antimalarial But clt has poor aqueous solubility (< 1 mg/l) and is hydrolyzed in acidic medium   Norfloxacin and Ciprofloxacin: Broad-spectrum antibacterial agents Currently marketed solid dose of norfloxacin is bcs class iv Fluoroquinone–cooh cocrystals of improved solubility and stability crystallized
...Read More

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Nature of Business

Service Provider

Total Number of Employees

Upto 10 People

Year of Establishment

2011

Legal Status of Firm

Private Limited Company

Annual Turnover

Upto Rs. 50 Lakh

GST Number

36AAECC3571B1Z1
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Crystalin Research Private LimitedPlot 81 A/C, Unit D, MLA Colony Road No. 12, Banjara Hills, Near Church Road, Banjara Hills,
Hyderabad-500034, Telangana, India

Mahalaxmi Boddupalli (Director)

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