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Is diabetes insipidus permanent?
A. Yes, almost always. However, in rare cases, following operations at the base of the brain, diabetes insipidus may develop which is only temporary.

Are any special precautions needed for travel?
A. When traveling to a hot climate, extra fluid intake will be needed due to extra loss of fluid as sweat. Your specialist will need to advise you about this. Usually your normal dose of vasopressin will be sufficient. If you are in a hot climate you will need to store your drops or spray in a cool place (but not in direct contact with ice as it shouldn’t be frozen). If you don’t have a cool bag, don’t worry. Try wrapping the bottle in wet toilet paper and keep it in a plastic bag. Vasopressin tablets can be kept at room temperature.

Will any adverse effects occur if I leave the medication out of the fridge?
A. Intranasal drops and sprays need to be refrigerated. If they are left out for a long time, they may become less effective and a larger dose of vasopressin would therefore the required to achieve the usual effect. Tablets of vasopressin do not require special storage requirements.

Are there any adverse effects of drinking alcohol?
A. Normally, there is an interaction with alcohol which reduces vasopressin secretion so in individuals with partial diabetes insipidus there may be the need for additional treatment. In patients who are deficient in their own vasopressin there will obviously be no interaction. However, drinking large quantities of fluid, even in the form of alcohol, after taking vasopressin could lead to the risk of water overload.

What happens if don’t feel thirsty?
A. If you have the problem whereby you lack the sense of thirst, please read the section on page 10. However, if you are unwell and have difficulty taking fluids or solids then you should seek medical advise as temporary inpatient care may be necessary. In addition, in very hot weather, heat stroke can lead to sleepiness and a reduced thirst. Particular precautions will therefore be needed.

What happens if I miss a dose or the does not get absorbed?
A. If this happens you will notice that you start passing a lot of urine and getting thirsty at a time when the vasopressin treatment would normally be working. If this occurs within 2 hours of the time when you normally take the dose, and you are pretty sure that you’ve missed it or something was wrong with the administration, then it is safe to take half the dose again. If, however, several hours have elapsed, it is probably safer to drink yourself out of trouble. Take a jug of water and keep up with the fluid losses until you would normally take your next dose.

Is it dangerous to take too much vasopressin treatment?
A. Yes, This will cause the retention of too much fluid in the body and will result in an increase in weight, swelling or puffiness of the limbs, and increase in blood pressure and headaches. The increased fluid retention causes a lower concentration of substances in the blood. Hyponatraemia, or low blood sodium, may result in fits. This can be a serious condition and generally it is safer to give too little vasopressin than too much.

Is it important that I carry notification about my condition?
A. Yes, An older child or adolescent will need to have an SOS Talisman or Medic Alert necklace or bracelet. Details about these are available from the Child Growth Foundation.

If I have a cold, will this affect my treatment?
A. It may do if your vasopressin treatment is by intranasal spray or drops. If only one nostril is blocked, the other one will be adequate for treatment. If, however, you nose is totally blocked, you may not absorb enough medicine and you will need to consult your doctor. In these circumstances.
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