Landmark Pharma

Indication:

• Dolutegravir (DTG) is an FDA-approved drug for the treatment of HIV infection.
• Dolutegravir is an integrase inhibitor.
• Mechanism of action:Naivex (Dolutegravir)is an HIV-1 antiviral agent.
• It inhibits HIV integrase by binding to the active site and blocking the strand transfer step to retroviral DNA integration. This is an essential step of the HIV replication cycle and will result in an inhibition of viral activity.
• Naivex (Dolutegravir)has a mean EC50 value of 0.5 nM (0.21 ng/mL) to 2.1 nM (0.85 ng/mL) in peripheral blood mononuclear cells (PBMCs) and MT-4 cells.

Leveraging the skills of our qualified team of professionals, we are instrumental in offering a wide range of Viraday Tablets.

With the support of our vendors highly experienced team of professionals, we are engaged in offering quality assured Tenvir EM Tablet. Used in combination with other antiviral medications in patients with acquired immunodeficiency syndrome, offered tablet is precisely processed by our skilled professionals using quality proven chemical compounds and ultra-modern technology. So as to retain their effectiveness, this tablet is well packed using optimum quality packaging material. In order to ensure their quality, this tablet is tested against various parameters.

Features:

• Highly effective
• Pure
• Available in various packaging option

Indication:

This drug is used with other HIV medications to help control HIV infection. It helps to decrease the amount of HIV in your body so your immune system can work better. This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life. Efavir (Efavirenz) belongs to a class of drugs known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Mechanism of action:

Efavir (Efavirenz) falls in the NNRTI class of antiretrovirals. Both nucleoside and non-nucleoside RTIs inhibit the same target, the reverse transcriptase enzyme, an essential viral enzyme which transcribes viral RNA into DNA. Unlike nucleoside RTIs, which bind at the enzyme''s active site, NNRTIs act allosterically by binding to a distinct site away from the active site known as the NNRTI pocket.

Efavir (Efavirenz) is not effective against HIV-2, as the pocket of the HIV-2 reverse transcriptase has a different structure, which confers intrinsic resistance to the NNRTI class.

Dosage and Administration:

Use Efavir (Efavirenz) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Take Efavir (Efavirenz) by mouth on an empty stomach. Taking Efavir (Efavirenz) with food, especially with a high-fat meal, may lead to increased blood levels of Efavir (Efavirenz). This may increase your risk of side effects.

· Take Efavir (Efavirenz) with a full glass of water (8 oz [240 mL]).

· Swallow Efavir (Efavirenz) whole. Do not break, crush, or chew before swallowing. If you cannot swallow Efavir (Efavirenz) whole, tell your doctor.

· Do NOT take more than the recommended dose, change your dose, or stop taking Efavir (Efavirenz) without checking with your doctor.

· Take Efavir (Efavirenz) at the same time every day, preferably at bedtime unless otherwise directed by your doctor.

· Continue to use Efavir (Efavirenz) even if you feel well. Do not miss any doses.

Side effects:

Dizziness, trouble sleeping, drowsiness, unusual dreams, and trouble concentrating may frequently occur. These side effects may begin 1-2 days after starting this medication and usually go away in 2-4 weeks. They are also reduced by taking Efavir (Efavirenz) on an empty stomach at bedtime. Avoid alcohol and street drugs while taking Efavir (Efavirenz). They may worsen these side effects. Tiredness, headache, nausea, vomiting, and diarrhea may also occur.

Precaution:

Before taking Efavir (Efavirenz), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Store Efavir (Efavirenz) at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly closed container away from heat, moisture, and light.

Efavirenz Tablets IP

Indication:

• Treating HIV infection when used along with other medicines.
• It is also used with other medicines to help prevent women from passing the HIV virus to the fetus during pregnancy.
• Zidovir (Zidovudine) is an antiviral.
• It works by blocking the reproduction of the HIV virus.

• Before taking Zidovir (Zidovudine), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
• This product may contain inactive ingredients, which can cause allergic reactions or other problems.
• Talk to your pharmacist for more details.
• Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems (such as hepatitis B or C, cirrhosis), alcohol use, low red/white blood cells.

Store:

• Zidovir (Zidovudine) is handled and stored by a health care provider.
• You will not store it at home.
• Keep all medicines out of the reach of children and away from pets.

Treating HIV infection in certain patients along with other antiretroviral medicines. Daruvir (Darunavir) must always be taken along with another medicine called ritonavir. Daruvir (Darunavir) is an HIV protease inhibitor. It works by blocking the growth of HIV.

Mechanism of action:

Daruvir (Darunavir) is a HIV protease inhibitor which prevents HIV replication by binding to the enzyme's active site, thereby preventing the dimerization and the catalytic activity of the HIV-1 protease. Daruvir (Darunavir) selectively inhibits the cleavage of HIV encoded Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virus particles. Structual analyses suggests that the close contact that Daruvir (Darunavir) has with the main chains of the protease active site amino acids (Asp-29 and Asp-30) is an important contributing factor to its potency and wide spectrum of activity against multi-protease inhibitor resistant HIV-1 variants. Daruvir (Darunavir) can also adapt to the changing shape of a protease enzyme because of its molecular flexibility. Daruvir (Darunavir) is known to bind to two distinct sites on the enzyme: the active site cavity and the surface of one of the flexible flaps in the protease dimer.

Dosage and Administration:

Use Daruvir (Darunavir) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Take Daruvir (Darunavir) by mouth with food. Ritonavir should be taken at the same time as Daruvir (Darunavir).

· Swallow Daruvir (Darunavir) whole with a drink, such as water or milk. Do not break, crush, or chew before swallowing. If you are unable to swallow Daruvir (Darunavir) whole, contact your doctor. Daruvir (Darunavir) may not be right for you.

· If you also take didanosine, do not take it within 1 hour before or 2 hours after taking Daruvir (Darunavir). Check with your doctor if you have questions.

· Taking Daruvir (Darunavir) at the same time(s) each day will help you remember to take it.

· Continue to take Daruvir (Darunavir) even if you feel well. Do not miss any doses.

Side effects:

Since Daruvir (Darunavir) is always taken with other HIV medications, it may be difficult to tell whether Daruvir (Darunavir) is causing certain side effects. However, Daruvir (Darunavir) is known to cause diarrhea, nausea, vomiting, stomach pain, and headache. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Precaution:

Before taking Daruvir (Darunavir), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Since Daruvir (Darunavir) must be taken with ritonavir, tell your doctor if you are allergic to ritonavir. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Store Daruvir (Darunavir) at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light.
Darunavir Tablets 300mg

• Valten (Tenofovir )is used with other HIV medications to help control HIV infection.
• It helps to decrease the amount of HIV in your body so your immune system can work better.
• This lowers your chance of getting HIV complications (such as new infections, cancer) and improves your quality of life.

Mechanism of action:

• Valten (Tenofovir )is a defective adenosine nucleotide that selectively inhibits the action of reverse transcriptase, while only weakly interfering with mammalian DNA polymerases α, β, and mitochondrial DNA polymerase γ.
• Valten (Tenofovir )prevents the formation of the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.
• A phosphodiester bond cannot be formed because the Valten (Tenofovir )molecule lacks an —OH group on the 3′ carbon of its deoxyribose sugar.
• Once incorporated into a growing DNA strand, Valten (Tenofovir )causes premature termination of DNA transcription.
• The drug is classified as a nucleotide analogue reverse transcriptase inhibitor (NtRTI).
• Reverse transcriptase is a crucial viral enzyme in retroviruses such as human immunodeficiency virus (HIV) and in hepatitis B virus infections.