Landmark Pharma

• Treating chronic hepatitis C virus (HCV) infection in certain patients. Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents.
• It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.Sofosbuvir and Ledipasvir is a combination and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Sofosbuvir & Ledipasvir tablets, may sometimes be used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir ledipasvir , ledipasvir and sofosbuvir , ledipasvir and sofosbuvir cost, ledipasvir & sofosbuvir tablets, sofosbuvir ledipasvir price.

Mechanism of action:

• Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

• Treating chronic hepatitis C virus (HCV) infection in certain patients.
• Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents.
• It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Sofosbuvir and Ledipasvir is a combination and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Sofosbuvir & Ledipasvir tablets, may sometimes be used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir ledipasvir , ledipasvir and sofosbuvir , ledipasvir and sofosbuvir cost, ledipasvir & sofosbuvir tablets, sofosbuvir ledipasvir price.

Mechanism of action:

• Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion.
• Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication.
• The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

• Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus.
• Long-term infection can cause liver damage, rarely liver cancer, and liver failure.
• Entecavir helps to decrease the amount of hepatitisB virus in your body.
• It is unknown if this medication lowers your chance of gettingliver cancer or liver damage.
• Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

• Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.
• It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV. Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV.

• Store entecavir in the original carton at room temperature, between 68 and 77 degrees F (20 and 25 degrees C).
• Store away from heat, moisture, and light.
• Do not store in the bathroom.
• Keep entecavir out of the reach of children and away from pets.

• Virofix ( Ribavirin)is used in combination with other antiviral medications to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
• Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.
• Virofix ( Ribavirin)works by reducing the amount of hepatitis C virus in your body, which may help your liver recover.

Mechanism of action:

• Virofix ( Ribavirin)is readily phosphorylated intracellularly by adenosine kinase to Virofix ( Ribavirin)mono-, di-, and triphosphate metabolites.
• Virofix ( Ribavirin)triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral) and can be incorporated into RNA in RNA viral species..
• Guanylyltranserase inhibition stops the capping of mRNA.
• These diverse effects result in a marked reduction of intracellular guanosine triphosphate (GTP) pools and inhibition of viral RNA and protein synthesis.
• Virofix ( Ribavirin)is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.

Side effects:

• All medicines may cause side effects, but many people have no, or minor, side effects.
• Check with your doctor if any of these most COMMON side effects persist or become bothersome:
• Diarrhea; dizziness; dry mouth; dry skin; hair loss; joint pain; loss of appetite; mild headache, nausea, or vomiting; mild stomach pain; tiredness; trouble sleeping; upset stomach; weakness or fatigue.

Precaution:

• Before taking Virofix ( Ribavirin), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
• This product may contain inactive ingredients, which can cause allergic reactions or other problems.
• Talk to your pharmacist for more details.

Store:

• Store Virofix ( Ribavirin) between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Virofix ( Ribavirin)out of the reach of children and away from pets

• Velasof is an combination of velpatasvir 100mg+ Sofosbuvir 400mg.
• Velasof is a two-drug combination for the treatment of hepatitis C.
• It is administered as a single daily pill containing the viral NS5A inhibitor velpatasvir and sofosbuvir,a nucleotide inhibitor of the viral RNA polymerase.
• It is the first treatment, that works for all genotypic, and is taken entirely by mouth.
• A single tablet regimen is used for adults with genotype 1-6 chronic hepatitis C virus (HCV) infection with pangenotypic activity.

This medication is a combination of sofosbuvir and velpatasvir and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. sofosbuvir velpatasvir, sofosbuvir and velpatasvir, velpatasvir sofosbuvir, sofosbuvir velpatasvir brand name, It may sometimes be used with another antiviral medication (ribavirin). These drugs velpatasvir genotype 3 work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir velpatasvir cost, sofosbuvir velpatasvir, sofosbuvir plus velpatasvir available velpatasvir india.

• The most common adverse reactions with velpatasvir were headache and fatigue and when used with RBV in decompensated cirrhotics were fatigue, anemia, nausea, headache, insomnia, and diarrhea.
• Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
• Many people using this medication do not have serious side effects.

Uses:

This medication is a combination of ledipasvir and sofosbuvir and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It may sometimes be used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Ledipasvir/sofosbuvir is a prescription medication used to treat chronic hepatitis C virus (HCV) genotype 1, 4, 5, or 6 infection.

Ledipasvir/sofosbuvir belongs to a group of drugs called antiviral medications. They work by decreasing the amount of hepatitis C virus (HCV) in the body.

Overview:

• Ledipasvir/sofosbuvir is a prescription medication used to treat chronic hepatitis C virus (HCV) genotype 1, 4, 5, or 6 infection. Ledipasvir/sofosbuvir is also used to treat people infected with HCV and HIV. Ledipasvir/sofosbuvir may also be used with the medication ribavirin to treat people with HCV and cirrhosis.
• It comes as a single tablet that contains 2 medications: ledipasvir and sofosbuvir . Ledipasvir/sofosbuvir belongs to a group of drugs called antiviral medications. They work by decreasing the amount of hepatitis C virus (HCV) in the body.
• This medication comes in tablet form and is taken once daily.
• Common side effects of ledipasvir/sofosbuvir include tiredness, headache, and weakness.

Usage:

• Take ledipasvir/sofosbuvir exactly as your healthcare provider tells you to take it. Do not change your dose unless your healthcare provider tells you to.
• Do not stop taking ledipasvir/sofosbuvir without first talking with your healthcare provider. If you think there is a reason to stop taking it, talk to your healthcare provider before doing so.
• Take ledipasvir/sofosbuvir once daily, with or without food.
• If you miss a dose, take the missed dose as soon as you remember the same day. Do not take more than 1 tablet of ledipasvir/sofosbuvir in a day. Take your next dose at your regular time the next day.
• Ledipasvir & Sofosbuvir Dosage
• Ledipasvir/sofosbuvir is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet.
• The recommended dosage of is one tablet taken orally once daily with or without food.

Precautions:

• Contact your healthcare provider immediately if you develop weakness, fatigue, nausea, vomiting, yellow eyes or skin, loss of appetite, or light-colored stools. These may be signs and symptoms of a serious liver problem.
• Do not take ledipasvir/sofosbuvir if you:
• are allergic to ledipasvir/sofosbuvir or to any of its ingredients
• are taking medications containing sofosbuvir, including Solvadi.

Safety Information:

Before taking ledipasvir/sofosbuvir, tell your doctor or pharmacist if you are allergic to either of the drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

• Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
• Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
• These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.
• Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.
• Mechanism of action:The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b.
• Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes.
• We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web.
• Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation.

Daclatasvir 60mg is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Daclatasvir 60mg tablet should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.Daclatasvir Price, Daclatasvir Cost.Daclatasvir Dose.

• Take daclatasvir exactly as your healthcare provider tells you to.·
• Do not change your dose unless your healthcare provider tells you to.·
• Do not stop taking daclatasvir without first talking with your healthcare provider.·
• Take daclatasvir 1 time each day with or without food.The recommended usage of daclatasvir to treat chronic hepatitis C virus is 60 mg taken orally once daily with or without food in combination with sofosbuvir.
• The recommended treatment duration is 12 weeks.

• Tiredness, headache, nausea, or diarrhea may occur.
• If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.
• Many people using this medication do not have serious side effects.

• Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
• Daclatasvir should never be used without sofosbuvir.
• Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
• These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.

• Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.
• Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).
• These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.
• Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Sofosbuvir 400mg tablets is used with other antiviral medications (such as ribavirin, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir cost, Sofosbuvir price , Sofosbuvir Buy online.

Mechanism of action:

• The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b.
• Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes.
• We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain.
• Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking.
• Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV.
• These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web.
• Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation.

• Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus.
• Long-term infection can cause liver damage, rarely liver cancer, and liver failure.
• Entecavir helps to decrease the amount of hepatitisB virus in your body.
• It is unknown if this medication lowers your chance of gettingliver cancer or liver damage.
• Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

• Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.
• It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV.
• Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV.

• Take entecavir on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal.·
• Entecavir works best if it is taken at the same time each day.· Continue to take entecavir even if you feel well.
• Do not miss any doses.·
• If you miss a dose of entecavir, take it as soon as possible.
• If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.
• Do not take 2 doses at once.

In order to keep pace with the never-ending demands of customers, we are involved in offering a wide range of Velpanat Tablets.

• Ledipasvir/sofosbuvir is a prescription medication used to treat chronic hepatitis C virus (HCV) genotype 1, 4, 5, or 6 infection. Ledipasvir/sofosbuvir is also used to treat people infected with HCV and HIV. Ledipasvir/sofosbuvir may also be used with the medication ribavirin to treat people with HCV and cirrhosis.
• It comes as a single tablet that contains 2 medications: ledipasvir and sofosbuvir . Ledipasvir/sofosbuvir belongs to a group of drugs called antiviral medications. They work by decreasing the amount of hepatitis C virus (HCV) in the body.
• This medication comes in tablet form and is taken once daily.
• Common side effects of ledipasvir/sofosbuvir include tiredness, headache, and weakness.

• Take ledipasvir/sofosbuvir exactly as your healthcare provider tells you to take it. Do not change your dose unless your healthcare provider tells you to.
• Do not stop taking ledipasvir/sofosbuvir without first talking with your healthcare provider. If you think there is a reason to stop taking it, talk to your healthcare provider before doing so.
• Take ledipasvir/sofosbuvir once daily, with or without food.
• If you miss a dose, take the missed dose as soon as you remember the same day. Do not take more than 1 tablet of ledipasvir/sofosbuvir in a day. Take your next dose at your regular time the next day.
• Ledipasvir & Sofosbuvir Dosage
• Ledipasvir/sofosbuvir is a two-drug fixed-dose combination product that contains 90 mg of ledipasvir and 400 mg of sofosbuvir in a single tablet.
• The recommended dosage of is one tablet taken orally once daily with or without food.

• Contact your healthcare provider immediately if you develop weakness, fatigue, nausea, vomiting, yellow eyes or skin, loss of appetite, or light-colored stools. These may be signs and symptoms of a serious liver problem.
• Do not take ledipasvir/sofosbuvir if you:
• are allergic to ledipasvir/sofosbuvir or to any of its ingredients
• are taking medications containing sofosbuvir, including Solvadi

Safety Information:

Before taking ledipasvir/sofosbuvir, tell your doctor or pharmacist if you are allergic to either of the drugs; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

• Treating chronic hepatitis C virus (HCV) infection in certain patients.
• Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents.
• It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Sofosbuvir and Ledipasvir is a combination and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Sofosbuvir & Ledipasvir tablets, may sometimes be used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir ledipasvir , ledipasvir and sofosbuvir , ledipasvir and sofosbuvir cost, ledipasvir & sofosbuvir tablets, sofosbuvir ledipasvir price.

Mechanism of action:

• Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion.
• Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication.
• The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

• It is used for the treatment of hepatitis Cvirus (HCV) infection.
• Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects.
• That is a key component of older drug combinations for the treatment of HCV.

Sofosbuvir 400mg tablets is used with other antiviral medications (such as ribavirin, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir cost, Sofosbuvir price , Sofosbuvir Buy online.

Mechanism of action:

• Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase.
• The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator.
• The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:

• The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food.
• Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults.
• It is highly advisable to administer the drug under strict medical supervision and advice.