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Micro Orgo- Chem, Valsad

Valsad, Gujarat
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Micro Orgo Chem is involved in the manufacturing of a wide range of Active Pharmaceuticals Ingredients (API's)
Micro Orgo Chem is an innovative and dynamic Indian Pharmaceutical Company supplying highly integrated portfolio of finished Dosage Forms to pharmaceuticals and healthcare sectors. MICRO ORGO CHEM was founded in 1992 for manufacturing and marketing niche API's. Right from the inception, the company has laid emphasis on in-house R& D backed by a team of highly motivated research professionals and technocrats with latest technology. Based on our multifunctional services, high flexibility, efficiency and investment, we are able to meet the requirements of today's specific environment in the Pharmaceutical industry as a competent partner. We are a progressive and quality conscious Organization serving the pharmaceutical needs of diverse markets across the globe. Our detailed knowledge about national markets, information on market developments and global trends are updated on a daily basis by intensive communication with our offices and representations. Our world-wide contacts, competent staff and efficient logistics make MICRO ORGO CHEM your supplier of Active Pharmaceutical Ingredients & finished Dosage Forms and partner to take national or multinational projects from the basic idea through to completion. We have also tie ups with international companies and has maintained international quality standards for its complete product range.
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Nature of Business

Manufacturer

Year of Establishment

1992

Lumefantrine
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Lumefantrine

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Title:
Lumefantrine
Specification
IHS
Category
antimalerial
DMF Status
TP
CAS Registry number:
82186-77-4

Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with. The term "co-" is sometimes used to describe this combination. Lumefantrine is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.

IUPAC NAME : 2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl) methylidene]-9H-fluoren-4-yl]ethan-1-ol

Atc code no. : PO1BF01

Formula
   

C30H32Cl3NO

Mol. mass
   

528.939 g/mol

MECHANISM OF ACTION : The exact mechanism by which lumefantrine exerts its antimalarial effect is unknown. However, available data suggest that lumefantrine inhibits the formation of β-hematin by forming a complex with hemin and inhibits nucleic acid and protein synthesis.

ABSORPTION : Food increases absorption.
PROTEIN BINDING : 99.7% bound
HALF LIFE : ~ 4.5 days

TOXICITY : Common side effects of combination /lumefantrine therapy in adults include headache, anorexia, dizziness, and asthenia. Common side effects in children include pyrexia, cough, vomiting, anorexia, and headache. Possible serious adverse effects include QT prolongation, bullous eruption, urticaria, splenomegaly (9%), hepatomegaly (adults, 9%; children, 6%), hypersensitivty reaction, and angioedema.

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Hydroxocobalamin Acetate
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Hydroxocobalamin Acetate

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Title:
Hydroxocobalamin Acetate
Specification
BP/EP
Category
Nutrition Research, Vitamin B, Vitamin B12, Vitamins
DMF Status
TP
CAS Registry number:
22465-48-1

Molecular Weight :  1388.39

Empirical Formula : C64H91CoN13O16P
Protein binding     Very high (90%)
Metabolism     Primarily hepatic, cobalamins are absorbed in the ileum and stored in the liver.
Half-life     ~6 days

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Hydroxocobalamin Chlorode
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Title:
Hydroxocobalamin Chlorode
Specification
BP/EP
Category
Nutrition Research, Vitamin B, Vitamin B12, Vitamins
DMF Status
TP
CAS Registry number:
58288-50-9

storage temp. : 2-8°C
solubility : methanol: 10 mg/mL at 20 °C, clear, dark red

Safety

Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 26-36

Synonyms:
   

OH-CBL HCL;VITAMIN B12A;Einecs 261-200-3;
HYDROXOCOBALAMINE;
HYDROXOCOBALAMINE HCL;
AQUOCOBALAMIN CHLORIDE; HYDROXOCOBALAMIN HYDROCHLORIDE;

CBNumber:
   

CB2133735

Molecular Formula:
   

C62H90ClCoN13O15P

Formula Weight:
   

1382.82

MOL File:
   

58288-50-9.mol

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Succinylcholine Chloride

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Monograph number: 9044
Title: Succinyl Choline Chloride
Specification
IP/BP/EP/USP
Category
Muscle relaxant (Skeletal)
DMF Status
Open part DMF Available
CAS Registry number:
[306-40-1]
CAS name(s):
2,2prime-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[ N,N,N- trimethylethana minium] di chloride
Additional name(s):
bis [2-dimethylaminoethyl]succinate bis[methochlo ride]; 2-dimethylaminoethyl succinate dimethochloride; di acetylcholine dichloride; suxamethonium chloride; choline succinate dichloride; succinic acid bis[beta-dimethylamino eth yl] ester dimethochloride; choline chloride succinate (2:1); listenon
Trade name(s):
Anectine (Burroughs Wellcome) ; Lysthenon (Nycomed) ; Midarine (Wellcome) ; Quelicin (Abbott) ; Scoline (Duncan Flockhart) ; Sucostrin (Apothecon)
Molecular Formula:
C 14 H 30 Cl 2 N 2 O 4
Molecular Weight:
361.31
Percent Composition:
C 46.54%, H 8.37%, Cl 19.62%, N 7.75%, O 17.71%

Literature references:

Prepn: R. Fusco et al., Gazz. Chim. Ital. 79, 129 (1949); Tammelin, Acta Chem. Scand. 7, 185 (1953); O. Schmid, Austrian pat. 171,411 (1952 to OSSW), C.A. 47, 4902f (1953); C. H. Wang et al., Org. Prep. Proc. Int. 11, 93 (1979). Crystal structure: B. Jensen, Acta Chem. Scand. B 30, 1002 (1976). Toxicity data: P. Anttila, P. Ertama, Med. Biol. 56, 152 (1978). Comprehensive description: P. R. B. Foss, S. A. Benezra, . Profiles Drug Subs.  10, 691-704 (1981).
Properties:

Exists as a dihydrate at room temp, crystals, mp 156-163degrees. Anhydr form mp approximately190degrees . Slightly bitter taste. Freely sol in water (about 1 g/1 ml water). Soly in 95% ethanol: 0.42 g/100 ml. Spar ingly sol in benzene, chloroform. Practically insol in ether. The pH of a 2-5% aq soln may vary from 4.5 to 3.0. Solns without stabilizers (e.g., 0.1% methyl p- hydr oxybenzoate) must be kept refrigerated, they are incompatible with alka line agents, such as thiopental sodium. LD 50 i.v. in mice: 0.45 mg/kg (Anttila, Ertama) .
Melting Point:

156-163degrees; mp approximately190

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Dihydroartemisinin

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Title:
Dihydroartemisinin
Specification
IHS
Category
Antimalarial
DMF Status
TP
CAS Registry number:
[71393-50-9]

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Title:
Hydroxocobalamin Sulphate
Specification
BP/EP
Category
Nutrition Research, Vitamin B, Vitamin B12, Vitamins
DMF Status
TP
CAS Registry number:
15671-27-9

storage temp. : 2-8°C
solubility : SOLUBLE IN WATER, SOME DECOMPOSITION MAY OCCUR ON DRYING.

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Manufacturer & Exporter of Eflornithine Hydrochloride Monohydrate
Monograph number:
3564
Title:
Eflornithine
Specification
IHS (In House Specification)
Category
Antineoplastic, Antipneumocystic Antiprotozoal, To Remove excess facial hair
DMF Status
open part DMF Available
CAS Registry number:
[96020-91-6]
CAS name(s):
2-(Difluoromethyl)-DL-ornithine
Additional name(s):
alpha-difluoromethylornithine; DFMO
Drug Code(s):
RMI
Molecular formula:
C 6 H 12 F 2 N 2 O 2
Molecular weight:
182.17
Percent Composition:
C 39.56%, H 6.64%, F 20.86%, N 15.38%, O 17.57%.
Literature references:
Irreversible inhibitor of ornithine decarboxylase. Prepn: B. W. Metcalf et al., J. Am. Chem. Soc. 100, 2551 (1978); P. Bey et al., J. Org. Chem. 44, 2732 (1979). Antiproliferative effects on cultured tumor cells: P. S. Mamont et al., Biochem. Biophys. Res. Commun. 81, 58 (1978); on Ehrlich ascites cells in rats: L. Alhonen-Hon gis to et al., Acta Chem. Scand. B33, 559 (1979). Inhibition of polyamine biosynthesis: E. Houmllttauml et al., Biochem. J. 178, 109 (1979). Antitrypanosomal activity in mice: C. J. Bacchi et al., Science 210, 332 (1980). Pharmacokinetics in humans: K. D. Haegele et al., Clin. Pharmacol. Ther. 30, 210 (1981). Clinical evaluations in Pneumocystis carinii pneu monia: J. A. Golden et al., West. J. Med. 141, 613 (1984); in trypanosomiasis: S. Van Nieuwenhove et al., Trans. Royal Soc. Trop. Med. Hyg. 79, 692 (1985); in cancer chemotherapy: M. D. Abeloff et al., Cancer Treat. Rep. 70, 843 (1986); V. A. Levin et al., ibid. 71, 459 (1987).
Derivative
Hydro chloride monohydrade
Molecular Formula
C 6 H 12 F 2 N 2 O 2 .HCl.H 2O.
CAS Registry
[96020-91-6]
Trade name(s)
Or nidyl (HMR)
Properties:
Crystals from ethanol/water
Melting Point:
183

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Triprolidine HCL

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Manufacturer & Exporter of Triprolidine HCL
Monograph number:
9877
Title
Triprolidine HCL
Specification
IP/BP/EP/USP
Category
Antihistaminic
DMF Status
open part DMF Available
CAS Registry number
[6138-79-0]
CAS name(s)
( E )-2-[1-(4-Methylphenyl)-3-(1-pyrroli dinyl)-1-propenyl]pyridine; trans- 2-[3-(1-pyrrolidinyl)-1- p- tol yl propenyl]pyridine
Additional name(s)
trans- 1-(2-pyridyl)-3-pyrrolidino-1- p- tolylprop-1-ene; trans- 1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene.
Molecular formula
C 19 H 22 N 2
Molecular weight
278.40
Percent Composition
C 81.97%, H 7.97%, N 10.06% .
Literature references
Histamine H 1 -receptor anta gonist. Prepn: Adamson, U.S. pats. 2,712,020; 2,712,023 (both 1955 to Burroughs Wellcome); Adamson et al., J. Chem. Soc. 1958, 312. Structure-activity studies: Ison, Casy, J. Pharm. Pharmacol. 23, 848 (1971). Crystal and molecular structure: James, Williams, Can. J. Chem. 52, 1880 (1974). Pharmacokinetics and antihistaminic effects in humans: K. J. Simons et al., J. Allergy Clin. Immunol. 77, 326 (1986). Comprehensive description: S. A. Benezra, C.-H. Yang, . Profiles Drug Subs . 8, 509-528 (1979)
Properties
Crystals from light petr, mp 59-61degrees . uv max (ethanol): 236 , 285 nm (epsi 15300, 6800)
Melting Point
59-61
UV Maxima
236;285
Derivative
Hydro chloride monohydrate
Molecular Formula
C 19 H 22 N 2 .HCl.H 2
CAS Registry
[6138-79-0]
 Drug code(s)
295C51
Trade name(s)
Actidil (Wellcome) , Actidilon (Wellcome) , Pro-Actidil (Wellcome) , Pro-Entra (Wellcome-Sumitomo) , Venen (Tanabe)
Properties
Crystals from water, mp 116-118degrees . uv max (etha nol): 235 , 283 nm (epsi 15000, 7400) . Moderately sol in water, ethanol, methanol
Melting Point
116-118
UV Maxima
235;283
Derivative
Oxalate
Molecular Formula
C 19 H 22 N 2 .C 2 H 2 O 4
Properties
crystals from methanol, dec 173-174degrees. uv max (ethanol): 233 , 283 nm (epsi 16200, 8200)

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Iron Sorbitol

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Manufacturer & Exporter of Iron Sorbitol
Title:Iron Sorbital

Specification:
IHS
Category
Hematinic
DMF Status
open part DMF Available
CAS Registry number:
[1338-16-5]

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Iron Dextran

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Manufacturer & Exporter of Iron Dextran
Title:
Iron Dextran (Vet) (10%)
Specification
IHS
Category
Hematinic
DMF Status
open part DMF Available
CAS Registry number:
[9004-66-4]

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Sodium Stearyl Fumarate

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Manufacturer & Exporter of Sodium Stearyl Fumarate
Title: Sodium Stearyl Fumarate

Specification:

USP/NF
Category
Excipients
DMF Status
US File No 20643
CAS Registry number:
[4070-80-8]

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Iron Sucrose

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Manufacturer & Exporter of Iron Sucrose
Title:
Iron Sucrose
Specification
IHS
Category
Hematinic
DMF Status
open part DMF Available
CAS Registry number:
[8047-67-4]

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