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Chromosome aberration study

Chromosome aberration study

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The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian cells.
Structural aberrations may be of two types, chromosome or chromatid.
With the majority of chemical mutagens, induced aberrations are of the chromatid type, but chromosome-type aberrations also occur.
An increase in polyploidy may indicate that a chemical has the
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Shree Krushna Gene Lab & Research Center

Manohar Plot, Rajkot, Gujarat
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Product Description

The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian cells.

Structural aberrations may be of two types, chromosome or chromatid.

With the majority of chemical mutagens, induced aberrations are of the chromatid type, but chromosome-type aberrations also occur.

An increase in polyploidy may indicate that a chemical has the potential to induce numerical aberrations.

Chromosome mutations and related events are the cause of many human genetic diseases and there is substantial evidence that chromosome mutations and related events causing alterations in oncogenes and tumour suppressor genes of somatic cells are involved in cancer induction in humans and experimental animals.

The in vitro chromosome aberration test may employ cultures of established cell lines, cell strains or primary cell cultures.

The cells used are selected on the basis of growth ability in culture, stability of the karyotype, chromosome number, chromosome diversity and spontaneous frequency of chromosome aberrations.


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Chromosome aberration study

About the Company

Nature of BusinessService Provider
IndiaMART Member SinceOct 2014

Introduction:

Shree Krushna Gene Lab and Research Centre supports genetic diagnosis and research on the human and model genomes and on all aspects of genetics, basic biochemistry and cell biology related to health and disease, including the translation of knowledge into health policy and practice, and the societal implications of genetic discoveries.

Infrastructure:

Shree Krushna Gene Lab and Research Centre design for Cytogenetic and molecular genetic diagnosis cum research full pledge laboratory. Each test is tested by trained and experienced technicians under the supervision of qualified Scientist.

Diagnostic services:

  1. Chromosome Karyotyping services from: Blood, Bonemarrow, Amniotic fluid, Cancer Cells, tissue, Asiatic fluid, Product of conception (POC)
  2. Molecular diagnosis tests (PCR BASED): TB, HIV, MTB, beta thalassemia, Y chromosome micro deletion, HLA B27, Cystic fibrosis, etc..

Predictive Toxicology Testing:

Toxicology profile with range in primary profiling and complete profiling of any novel, synthetic and analogue compound of commercial, pharmaceutical, industrial or any part of health sector are served according to need. (OECD guideline ) The wide range allows selective or complete profile study of compound depending upon the purpose of use and application. The few services under this portfolio are:

1. In Vitro Toxicity assay 2. In Vitro Geno Toxicity assay 3. Molecular Genotoxicity assay 4. Environmental toxicity 5. Drug/ Chemical / Dye genotoxicity 6. Cancer genetics

OECD 473 : “In Vitro Mammalian Chromosome Aberration Test”

OECD 479 : “Genetic Toxicology: In vitro Sister Chromatid Exchange

Assay in Mammalian Cells”

OECD 487 : “In Vitro Micronucleus Test”

OECD/Guideline : “COMET assay – Single cell electrophoresis”

OECD/Guideline : “MTT assay” Cell Viability testing.

OECD/Guideline : “Trypan blue” Cell Viability testing.

OECD 471 : “AMES Test – Bacterial Reverse Mutation Test”

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Seller Contact Details

Rahul P. Thumbar

Dr Rahul Thumbar, 23b Anupam Society, Near Rajnagar Society
Manohar Plot
Rajkot - 360004, Gujarat, India

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