Ubiquinol (CoQH2) in Costead is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human low-density lipoprotein (LDL). It plays an essential role in maintaining cellular defence against oxidative damage and also sustains the effects of vitamin E by regenerating the vitamin from the tocopheroxyl radical.
Key Benefits:-
1. Costead decreases Oxidative stress
2. Costead Improves kidney health
3. Costead boosts immunity and enhances heart health.
MECHANISM OF ACTION
CoQ10/Ubiquinol participates in the mitochondrial electron transport chain as a cofactor at the level of Complex III where it shunts electrons. It also acts as a lipophilic antioxidant in the mitochondrial membranes.
PHARMACOKINETICS
Ubiquinol is administered orally. Being lipophilic, it follows the uptake mechanisms of lipids in the gastrointestinal tract. Ubiquinol is first incorporated into chylomicrons following absorption and transported via the lymphatics to the circulation. There it is transported by triacylglycerol-rich lipoproteins to the liver where it is repackaged primarily into VLDL/LDL particles and HDL particles to a minor extent. About 95% of CoQ10 in circulation exists in its reduced form as Ubiquinol in humans.3,4 A major portion of CoQ10 in tissues is in the reduced form as Ubiquinol.5
CoQ10 has a Tmax of 6.5 h and an elimination half-life of 33.19 h. Chronic administration produces a dose-dependent increase in plasma CoQ10. Compared to CoQ10, administration of Ubiquinol raises serum levels 2-fold higher with chronic dosing and over 4-fold higher with acute dosing.6
INDICATIONS AND OTHER KNOWN CLINICAL USE
Supplementation with Ubiquinol replenishes depleted levels and circumvents CoQ10 deficiency.
CoQ10 deficiency has been reported in congestive heart failure,Type 2 diabetes,hepatitis, liver cirrhosis,hepatocellular carcinomas,ALS, Alzheimer's disease, juvenile fibromyalgia and Down's syndrome.
Statin drugs inhibit the endogenous production of CoQ10, which has been implicated in fatigue and myalgia; Ubiquinol replenishes CoQ10 stores in these patients.
DOSAGE & ADMINISTRATION
As a dietary supplement,
Recommended Use:
100 mg/d – Maintenance dose
200 mg/d – To replenish Ubiquinol levels and correct deficiencies
300 mg/d – For more severe deficiencies or to dose load initially & then decrease to 200 mg
STORAGE
Store at controlled room temperature (68-77° F)
CONTRAINDICATIONS / PRECAUTIONS
None
ADVERSE REACTIONS
Costead is generally well tolerated. As with any dietary supplement, some gastrointestinal discomfort may be experienced.
DRUG INTERACTIONS
Because of its structural similarity to vitamin K, it has been suggested that CoQ10 may have procoagulant activity and interfere with warfarin. While there are reports of individual case studies showing the interaction of CoQ10 and warfarin, other case studies involving highly monitored patients on warfarin specifically noted no interactions with CoQ10. A randomized, double-blind, placebo-controlled study designed to assess the effect of CoQ10 on warfarin also showed no effect. A prospective study did show an interaction, though by admission of the authors, the results may have been due to chance given a small population that self-reported the data.
Exports To: Nepal
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