Gestone injections contain the active ingredient progesterone, which is a naturally occurring female hormone. Gestone injections are used in the treatment of menstrual disorders, in assisted reproduction and to help maintain early pregnancy in women who have had recurrent miscarriages.
Progesterone is essential for the normal functioning of the reproductive system. The body produces progesterone at certain times of the menstrual cycle and this hormone regulates the growth and shedding of the womb lining. Gestone injections mimic the effects of your natural progesterone and so can be used in the treatment of menstrual problems such as irregular or heavy menstrual periods. The injections help regulate the healthy growth and normal regular shedding of the womb lining. An injection is given daily for 5 to 10 days each month, stopping two days before the expected start of your period.
Progesterone is also essential for maintaining a pregnancy. After ovulation, the corpus luteum (which is the empty follicle from which the egg was released) produces progesterone, which acts on the womb lining and causes it to thicken in preparation for a fertilised egg to implant. This is known as the luteal phase of the menstrual cycle. If an egg implants successfully into the womb, the corpus luteum continues to produce progesterone to maintain the pregnancy until the placenta develops fully. The placenta produces increasing amounts of progesterone until it is fully developed, when it then takes over the production of progesterone to continue to support the pregnancy.
In some women, insufficient progesterone is produced during the luteal phase and this causes problems with implantation of fertilised eggs into the womb lining and maintaining a pregnancy in the early stages. Gestone is used to treat this hormone deficiency and help a pregnancy to continue in women who have had three or more miscarriages. Gestone injections are normally started on about day 15 of the woman''s cycle (day one is the first day of your period.). The injections are usually continued until the placenta is producing enough progesterone to support the pregnancy.
Gestone injections can also be used to support pregnancy in women having infertility treatment with in vitro fertilisation (IVF) or gamete intra-fallopian transfer (GIFT). In this case the injections are started on the day the embryo or gametes have been transferred into the womb, to help implantation of the fertilised egg into the lining of the womb. The injections are continued for up to 16 weeks until the placenta is producing enough progesterone to support the pregnancy.
Gestone injections are given into the muscle of the buttock (intramuscularly).
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