CERTIFICATE OF ANALYSIS
PRODUCT NAME:L-PYROGLUAMIC ACIDCAS NO:98-79-3FROMULA:
MOLAR MASS:129.12 g·mol−1
MELTING POINT:184 °
CINFORMATION OF L-PYROGLUAMIC ACID
:Pyroglutamic acid is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactamPyroglutamic acid
(also known as PCA
, pidolic acid
, or pyroglutamate
for its basic form) is an uncommon and little studied amino acid derivative in which the free amino group of glutamic acid or glutamine cyclizes to form a lactam.
It is a metabolite in the glutathione cycle that is converted to glutamate by 5-oxoprolinase. Pyroglutamate is found in many proteins including bacteriorhodopsin. N
-terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate. This is one of several forms of blocked N
-terminals which present a problem for N
-terminal sequencing using Edman chemistry, which requires a free primary amino group not present in pyroglutamic acid. The enzyme pyroglutamate aminopeptidase can restore a free N
-terminus by cleaving off the pyroglutamate residueUSES
:The sodium salt of pyroglutamic acid – known either as sodium pyroglutamate, sodium PCA, or sodium pidolate – is used for dry skinand hair products, as it is a humectant. It has low toxicity and is not a skin irritant, but its use in products is limited by a high price.
L-pyroglutamic acid is sold online as a dietary supplement.
Magnesium pidolate, the magnesium salt of pyroglutamic acid, is a mineral supplement.