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Generic Name: Ivermectin

Drug Class: Anthelmintic / antiparasitic agent (macrocyclic lactone derivative) DrugBank+2PMC+2

Mechanism / Origin:
  • Ivermectin is a semi-synthetic derivative of avermectins (from Streptomyces avermitilis) DrugBank+1
  • It works by binding selectively to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells. This increases permeability to chloride ions, hyperpolarizes the cells, resulting in paralysis and death of the parasite. DrugBank+2PMC+2
  • Because mammals (including humans) do not have the same glutamate-gated chloride channels, and because ivermectin poorly crosses the mammalian blood–brain barrier in therapeutic doses, it is relatively safe at standard dosages (though safety is dose-dependent). Wikipedia+2DrugBank