Shreeji Medical

• Advagraf contains the active substance tacrolimus.
• It belongs to a group of medicines called immunosuppressants.
• After you have had an organ transplanted (liver, kidney), your body's immune system will try to reject the new organ. 
• Advagraf is used to control this immune reaction and help the body accept the transplanted organ.
• You can also receive treatment with Advagraf if you have a rejection reaction against a transplanted liver, kidney, heart or another organ, or if you have previously received other treatment that did not work against the immune reaction after the transplant.
• Advagraf is used in adults.

How To Use:

• Always use this medicine exactly as your doctor has told you. 
• Contact a doctor or pharmacist if you are unsure. 
• This medicine should only be prescribed for you by a doctor experienced in the treatment of transplant patients.
• Make sure you receive the same type of tacrolimus medicine each time you pick up your prescription, unless your transplant specialist has decided that you should switch to a different tacrolimus medicine. 
• This medicine should be taken once a day. 
• If the medicine does not look as usual, or if the instructions regarding dosage have changed, talk to your doctor or pharmacist as soon as possible to make sure that you have received the correct medicine.
• The starting dose given to prevent rejection of the transplanted organ is determined by the doctor and calculated based on your body weight.
• The first doses given soon after the transplant are usually in the range of 0.10-0.30 mg/kg body weight per day, depending on which organ has been transplanted. 
• When treating rejections, the same doses can be used.
• The dose depends on your general condition and which other immunosuppressive drugs you are taking. 
• After starting treatment with Advagraf, the doctor will take frequent blood tests from you to determine the correct dose. 
• The doctor will then regularly take blood tests to determine the correct dose and to adjust the dose from time to time.
• The doctor will usually reduce the dose of Advagraf as soon as your condition has stabilised.
• The doctor will give you exact information about how many capsules to take.
• You will need to take Advagraf every day for as long as you need immunosuppressive treatment to avoid rejection of the transplanted organ.
• You should keep in regular contact with your doctor.
• Take Advagraf on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour before your next meal.
• Take the capsules immediately after they are removed from the blister tray. 
• The capsules should be swallowed whole with a glass of water. 
• The desiccant in the foil package must not be swallowed.

If you take too much Advagraf:

• Contact a doctor or the nearest hospital/emergency room immediately if you have accidentally ingested too much Advagraf.

If you have forgotten to take Advagraf:

• If you have forgotten to take the Advagraf capsules in the morning, take them as soon as possible on the same day. 
• You should not take a double dose to replace a missed dose.

If you stop treatment with Advagraf:

• If you stop treatment with Advagraf, there may be an increased risk of the transplanted organ being rejected. 
• You must not stop the treatment without the doctor's advice.
• Ask your doctor or pharmacist if you have any questions about the use of this medicine.

Warnings And Precautions:

Do not use Advagraf:

• If you are allergic to tacrolimus or any of the other ingredients of this medicine.