Steadfast Medishield Pvt. Ltd

DESCRIPTION

Ubiquinol (CoQH2) in Costead is a reduced form of coenzyme Q10 (CoQ10) that acts as an active antioxidant that prevents the initiation and propagation of lipid peroxidation in biological membranes and human low-density lipoprotein (LDL). It plays an essential role in maintaining cellular defence against oxidative damage and also sustains the effects of vitamin E by regenerating the vitamin from the tocopheroxyl radical. 

Key Benefits:-

1. Costead decreases Oxidative stress

2. Costead Improves kidney health

3. Costead boosts immunity and enhances heart health.

MECHANISM OF ACTION

CoQ10/Ubiquinol participates in the mitochondrial electron transport chain as a cofactor at the level of Complex III where it shunts electrons. It also acts as a lipophilic antioxidant in the mitochondrial membranes.

PHARMACOKINETICS

Ubiquinol is administered orally. Being lipophilic, it follows the uptake mechanisms of lipids in the gastrointestinal tract. Ubiquinol is first incorporated into chylomicrons following absorption and transported via the lymphatics to the circulation. There it is transported by triacylglycerol-rich lipoproteins to the liver where it is repackaged primarily into VLDL/LDL particles and HDL particles to a minor extent. About 95% of CoQ10 in circulation exists in its reduced form as Ubiquinol in humans.3,4 A major portion of CoQ10 in tissues is in the reduced form as Ubiquinol.5

CoQ10 has a Tmax of 6.5 h and an elimination half-life of 33.19 h. Chronic administration produces a dose-dependent increase in plasma CoQ10. Compared to CoQ10, administration of Ubiquinol raises serum levels 2-fold higher with chronic dosing and over 4-fold higher with acute dosing.6

INDICATIONS AND OTHER KNOWN CLINICAL USE

Supplementation with Ubiquinol replenishes depleted levels and circumvents CoQ10 deficiency.

CoQ10 deficiency has been reported in congestive heart failure,Type 2 diabetes,hepatitis, liver cirrhosis,hepatocellular carcinomas,ALS, Alzheimer's disease, juvenile fibromyalgia and Down's syndrome.

Statin drugs inhibit the endogenous production of CoQ10, which has been implicated in fatigue and myalgia; Ubiquinol replenishes CoQ10 stores in these patients.

DOSAGE & ADMINISTRATION

As a dietary supplement,

Recommended Use:

100 mg/d – Maintenance dose

200 mg/d – To replenish Ubiquinol levels and correct deficiencies

300 mg/d – For more severe deficiencies or to dose load initially & then decrease to 200 mg

STORAGE

Store at controlled room temperature (68-77° F)

CONTRAINDICATIONS / PRECAUTIONS

None

ADVERSE REACTIONS

Costead is generally well tolerated. As with any dietary supplement, some gastrointestinal discomfort may be experienced.

DRUG INTERACTIONS

Because of its structural similarity to vitamin K, it has been suggested that CoQ10 may have procoagulant activity and interfere with warfarin. While there are reports of individual case studies showing the interaction of CoQ10 and warfarin, other case studies involving highly monitored patients on warfarin specifically noted no interactions with CoQ10. A randomized, double-blind, placebo-controlled study designed to assess the effect of CoQ10 on warfarin also showed no effect. A prospective study did show an interaction, though by admission of the authors, the results may have been due to chance given a small population that self-reported the data.

Description
Awaytox is a Pre-Probiotic combination, a blend of probiotic Lactobacillus and Bifidobacterium species, the two most important genuses associated with the human intestinal tract and oral adsorbent Lactitol monohydrate.
Patients with chronic disease have abnormal microbiota when compared to healthy individuals. Diet and impaired protein absorption, increased intestinal transit time, medications, and uremia may all contribute to unfavorable changes in microbiota. Probiotic is used to maintain a friendly bacterial balance for support to healthy digestion. Probiotics are used to eliminate uremic toxics in CKD patients and in patients undergoing dialysis.
CompositionBifidobacterium longum5 Billion CFULactobacillus acidophilus5 Billion CFUStreptococcus thermophilus5 Billion CFUTotal Count15 Billion CFULactitol monohydrate USP (Prebiotic)100 mgPharmacodynamics
Awaytox Pre-Probiotic is a blend of probiotic Lactobacillus and Bifidobacterium species, the two most important genuses associated with the human intestinal tract and oral adsorbent Lactitol monohydrate. Each capsule supplies 15 billion active cells, otherwise called colony forming units (CFU).
Lactobacillus acidophilus 5 billion CFU
Studies have shown that dialysis patients, who were given freeze-dried Lactobacillus acidophilus, have reduced concentration of toxins (methylamine, demethylmine, nitrosamines and several other carcinogenic amines) in the bloodstream. In addition, it also helps to prevent the growth of pathogenic bacteria in the small bowel.
Bifidobacterium longum 5 billion CFU
These bacteria utilize various phenolic and indole metabolic toxic compounds in the colonic region as its nutrients for growth.
Streptococcus thermophilus 5 billion CFU
This bacterium actually utilizes urea/Creatinine/uric acid as nutrients for its increased growth and survival and thus help cleanse the bloodstream of urea and uric acid.
Our extensive research provides strong evidence that the three power Probiotics help the human gastrointestinal tract function as a pseudo kidney to filter out waste products that are usually the responsibility of kidney.
Indication
Awaytox is indicated in Renal Impairment for reducing the burden on impaired kidney.
Dosage and Administration
The recommended dosage of Awaytox in CKD is 1-2 capsules with every meal. The dose should be adjusted to suit the requirements of the individual patients.
Adverse Side Effects
Probiotic bacteria are indigenous to the human intestinal tract and their introduction into the alimentary tract is not associated with adverse side effects or considered a risk to health.
The daily recommended dose, or exceeding the recommended daily dose, may cause irritation and possibly a change in stool characteristics. Dose adjustments will resolve overuse problems.
Interactions
Probiotics used too soon after an antibiotic dosing could result in a loss of antibiotic efficacy. Follow standard pharmacy recommendations for dosing separation of probiotic and antibiotic substances.
Probiotic gains in friendly bacteria populations will be reduced by antibiotic therapy. Patients should be encouraged to support and maintain probiotic populations during and after an antibiotic course.

How Does It Works

SN Fish Oil contains Omega 3 fatty acids comprised of EPA and DHA. They both work together to provide all the health benefits of improved heart health, smarter brain, strengthen bones and reduced inflammation. Omega 3 fatty acids are the major components of cell membrane and acts as powerful anti-oxidant that helps in reducing oxidative stress in the body. EPA works as a precursor of many eicosanoids that is related with reduction of inflammation in the body. On the other hand, DHA is a primary structural component of human brain, skin and retina. Declined levels of DHA is been associated with decline in cognitive functioning, neural cell death and symptoms of depression. Therefore, a balance between EPA and DHA is important for overall health and well being. SN Fish Oil is been extracted from single source Sardine fish, which provides high quality Omega 3 fatty acids that provides maximum benefits.

 Benefits of The SN Fish Oil

Healthy Heart: Consuming fish oil improves the lipid profile by increasing “good fat”, HDL and lowering total triglycerides. This improves the blood flow and makes the heart healthy. Higher level of bad cholesterol in body is associated with many cardiovascular diseases including Arrhythmias and plaque formation in arteries called as Atherosclerosis.

Smarter Brain: Adequate EPA and DHA are associated with improved cognitive functioning. They are present in the membrane of brain cells, preserving cell membrane health and facilitating communication between brain cells.  Strengthen Bones: With aging bones become more prone for breakage because of lower bone density. Adequate Omega 3 consumption plays a major role on different bone metabolisms which improves the bone density and prevent the chances of osteoporosis.

Reduce Inflammation: High intensity workout would lead to physical stress and if it is persistent then it can lead to inflammation and soreness of muscles. Higher level of inflammation reduces immunity of the body and increase the risk of infection and illness.  
Better Vision

Reduce symptoms of Metabolic Syndrome

Enhance Skin Health